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All Journal Current Biomedicine Jurnal Wicara Desa
Safitri, Nadiya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Veterinary

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Antidiarrheal potential of Nigella sativa L. infusion in mice: a phytochemical and efficacy evaluation Safitri, Nadiya; Mustika, Aulia Andi; Pristihadi, Diah Nugrahani; Sutardi, Lina Noviyanti; Purohita, Adwisto Saktika
Current Biomedicine Vol. 3 No. 1 (2025): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.1.31

Abstract

Background Nigella sativa L., commonly known as black cumin, is a medicinal plant widely recognized for its therapeutic properties. However, limited pharmacological evidence supports its antidiarrheal potential when prepared as an infusion. Objective This study aimed to evaluate the phytochemical composition and antidiarrheal efficacy of Nigella sativa infusion in mice. Methods A total of 30 mice were divided into five groups: negative control (Tween 80 [1%]), positive control (Loperamide HCl), and treatment groups receiving Nigella sativa infusion at concentrations of 25%, 50%, and 100%. Antidiarrheal activity was assessed using the intestinal protection method, with parameters including defecation frequency, stool consistency, diarrheal onset time, and diarrheal duration. Results Phytochemical analysis revealed the presence of flavonoids, alkaloids, tannins, and saponins in Nigella sativa infusion. The infusion demonstrated significant antidiarrheal activity across all tested concentrations (25%–100%), with the 50% concentration showing the highest efficacy, comparable to Loperamide in reducing defecation frequency, improving stool consistency, delaying diarrheal onset, and shortening diarrheal duration. Conclusion Nigella sativa infusion at 50% concentration exhibits promising antidiarrheal potential and warrants further development as a herbal remedy.
PEMANFAATAN LIMBAH SEKAM PADI UNTUK PEMBUATAN BRIKET ARANG DI DESA PESANGGRAHAN KECAMATAN MONTONG GADING KABUPATEN LOMBOK TIMUR Fahrussalam, Fahrussalam; Safitri, Nurlaila; Billyan, Qonita Mulkan; Arfianti, Eni; Ansori, Wahyu; Anastasya, Anastasya; Safitri, Nadiya; Supriani, Ade; Kahfi, Dwihan Restu Ali
Jurnal Wicara Vol 1 No 6 (2023): Jurnal Wicara Desa
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/wicara.v1i6.3457

Abstract

Kuliah Kerja Nyata (KKN) is a special form of community service in higher education. In the KKN PMD activities carried out in Pesanggrahan Village, Montong Gading District, East Lombok Regency, student groups carry out various activities with the main objective of utilizing rice husk waste because of the village's excellent agricultural potential. The purpose of this KKN activity is to answer various agricultural problems in the Pesanggrahan village community. This charcoal briquette training is very useful so that the Pesanggrahan area community can continue to utilize rice husk waste into appropriate technology products, namely charcoal briquettes that can be used as an alternative fuel to replace BB. . The methods used in making briquettes are (1) utilization of rice husk waste into charcoal briquettes; (2) training in making charcoal briquettes from rice husk waste; (3) use of briquettes as fuel. The results of these socialization and training activities succeeded in providing special skills to the local community, especially the farm women who were directly involved in the production of briquettes. In addition, the KKN group also carried out various other activities such as branding Pesanggrahan coffee products, making garden plant shelves, Joben Lestari Proklim inspection activities, Posyandu activities, greening program activities, coaching and cleaning the village environment. The results of these activities show that this KKN activity is able to answer some of the problems that exist in Pesanggrahan village.
PEMANFAATAN LIMBAH SEKAM PADI UNTUK PEMBUATAN BRIKET ARANG DI DESA PESANGGRAHAN KECAMATAN MONTONG GADING KABUPATEN LOMBOK TIMUR Fahrussalam, Fahrussalam; Safitri, Nurlaila; Billyan, Qonita Mulkan; Arfianti, Eni; Ansori, Wahyu; Anastasya, Anastasya; Safitri, Nadiya; Supriani, Ade; Kahfi, Dwihan Restu Ali
Jurnal Wicara Vol 1 No 6 (2023): Jurnal Wicara Desa
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/wicara.v1i6.3457

Abstract

Kuliah Kerja Nyata (KKN) is a special form of community service in higher education. In the KKN PMD activities carried out in Pesanggrahan Village, Montong Gading District, East Lombok Regency, student groups carry out various activities with the main objective of utilizing rice husk waste because of the village's excellent agricultural potential. The purpose of this KKN activity is to answer various agricultural problems in the Pesanggrahan village community. This charcoal briquette training is very useful so that the Pesanggrahan area community can continue to utilize rice husk waste into appropriate technology products, namely charcoal briquettes that can be used as an alternative fuel to replace BB. . The methods used in making briquettes are (1) utilization of rice husk waste into charcoal briquettes; (2) training in making charcoal briquettes from rice husk waste; (3) use of briquettes as fuel. The results of these socialization and training activities succeeded in providing special skills to the local community, especially the farm women who were directly involved in the production of briquettes. In addition, the KKN group also carried out various other activities such as branding Pesanggrahan coffee products, making garden plant shelves, Joben Lestari Proklim inspection activities, Posyandu activities, greening program activities, coaching and cleaning the village environment. The results of these activities show that this KKN activity is able to answer some of the problems that exist in Pesanggrahan village.
Co-Authors Anastasya, Anastasya Ansori, Wahyu Arfianti, Eni Aulia Andi Mustika Billyan, Qonita Mulkan Diah Nugrahani Pristihadi Fahrussalam, Fahrussalam Kahfi, Dwihan Restu Ali Lina Noviyanti Sutardi Purohita, Adwisto Saktika Safitri, Nurlaila Supriani, Ade