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All Journal Borneo Journal Of Pharmascientech Indonesian Journal of Pharmaceutical Education Jurnal Abdimas Kesehatan Terpadu
Nugroho, Didi
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Peningkatan Pengetahuan Lansia Anggrek Bulan Untuk Pencegahan Kehilangan Gigi Octarina; Cindy; Nugroho, Didi; Kusnoto, Joko; Roro Asyurati Asia, Raden; Sundjoyo, Mikha
JURNAL ABDIMAS KESEHATAN TERPADU Vol. 3 No. 1 (2024): Jurnal Abdimas Kesehatan Terpadu
Publisher : Fakultas Kedokteran Gigi, Universitas Trisakti bekerjasama dengan Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jakt.v3i1.20122

Abstract

Dental and oral health for elderly is crucial and has impact on the individual’s general health. Physical decline in the elderly is characterized by skin starting to shrink, hair beginning to change colour, loss of bone density, ability to see up to loss of mucous teeth. Tooth loss can interfere with the function of chewing, speaking and aesthetics. This condition can be aggravated by poor dental and oral hygiene. Therefore, dental health education is important to provide elderly an information about how to maintain oral health and prevent dental problem. The method used in this research is by providing education through power point media, given to Anggrek Bulan Elderly Community in November 25th 2023. Evaluation of participants’ knowledge was carried out before and after education by giving assessment sheet in the form of multiple choices to determine the level of community knowledge. Based on evaluation results, it was found that there was an increase in knowledge among the participants. This can be seen in average value of post-test results which has increased.
Antibacterial Efficacy of AgNO₃ Combined with Cymbopogon citratus Extract and Chitosan Nanocomposite Against Pseudomonas aeruginosa Azrianty, Annisa; Komariah, Komariah; Ranggaini, Monica Dewi; Anggraeni, Rezky; Halim, Johni; Nugroho, Didi
Indonesian Journal of Pharmaceutical Education Vol 5, No 2 (2025): May–August 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i2.30641

Abstract

Infections caused by pathogenic bacteria such as Pseudomonas aeruginosa present significant challenges in clinical practice, particularly due to rising resistance to conventional antibiotics. The development of environmentally friendly, nanotechnology-based antibacterial agents is considered a promising alternative. This study aimed to evaluate the antibacterial activity of a nanocomposite comprising silver nitrate (AgNO₃), Cymbopogon citratus leaf extract, and chitosan against P. aeruginosa. The nanocomposite was synthesized using a green synthesis method, with plant extract serving as a natural reducing agent and chitosan as a nanoparticle stabilizer. Antibacterial activity was assessed via disk diffusion against five concentrations (6.25, 12.5, 15, 25, and 50 mg/mL), and compared to positive (chlorhexidine) and negative (acetic acid) controls. The results showed that the 6.25 mg/mL concentration produced the largest inhibition zone (average 11 mm), although it did not surpass the effectiveness of chlorhexidine. The inhibition zones remained stable for up to 72 hours, indicating sustained antibacterial activity. A decline in efficacy at 50 mg/mL was observed, likely due to nanoparticle aggregation and biological saturation. These findings support the potential of AgNO₃–C. citratus–chitosan nanocomposite as a natural-based alternative antibacterial agent. Further studies are recommended to characterize its physicochemical properties, elucidate its mechanism of action, and evaluate its toxicity and applicability in pharmaceutical and biomedical contexts.
Efektivitas Enkapsulasi Nano Kitosan Serai Dapur dalam Meningkatkan Depolarisasi Mitokondria pada Sel Kanker HSC-3 Komariah, Komariah; Moksidy, Jenyfer Ignatia; Nugroho, Didi; Ranggaini, Dewi; Anggraeni , Rezky; Halim , Johni
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.602

Abstract

Oral cancer ranks 12th among the most common types of cancer worldwide, with a prevalence of approximately 25%-40% occurring on the lateral borders and the underside of the tongue. Conventional therapies often cause side effects that damage normal cells, prompting the use of safer natural alternatives, such as Cymbopogon citratus (lemongrass). The active compounds in lemongrass leaves can enhance the production of reactive oxygen species (ROS), which trigger apoptosis through the depolarization of mitochondrial membrane potential (MMP). To improve the stability of these active compounds, they are encapsulated with chitosan, which is modified into nanoparticles to enhance diffusion through cell membranes, thereby increasing their effectiveness as anticancer agents. This study involved nine groups, including a negative control, a positive control (doxorubicin), nano chitosan, lemongrass extract, and five treatment groups with various encapsulation concentrations (100%, 75%, 50%, 25%, and 12.5%). The results showed that nano chitosan encapsulation of lemongrass extract significantly increased MMP depolarization compared to the control. The depolarization effect increased with higher encapsulation concentrations, with the lowest red fluorescence intensity observed at the 100% concentration, indicating the highest level of depolarization in HSC-3 cells.
Co-Authors Anggraeni , Rezky Anggraeni, Rezky Azrianty, Annisa Cindy Halim , Johni Halim, Johni Joko Kusnoto Komariah Komariah Moksidy, Jenyfer Ignatia Octarina Ranggaini, Dewi Ranggaini, Monica Dewi Roro Asyurati Asia, Raden Sundjoyo, Mikha