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All Journal Jurnal Biomedika dan Kesehatan JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Rayhansyah, Vito
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbedaan Fungsi Sistolik Ventrikel Kanan antara Hipertensi Arteri Pulmonal dan Hipertensi Vena Pulmonal Rayhansyah, Vito; Yanni, Mefri; Irramah, Miftah; Hamdani, Rita; Revilla, Gusti; Linosefa, Linosefa
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.14-25

Abstract

Background Pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) are both associated with increased right ventricular (RV) afterload, potentially leading to RV systolic dysfunction. Despite its prognostic value in predicting right heart failure (RHF), echocardiographic evaluation of RV function remains underutilized in the routine assessment of patients with PAH and PVH. Methods This study aims to evaluate differences in RV systolic function between PAH and PVH patients. A total of 116 patients (58 PAH and 58 PVH) were selected through consecutive sampling from medical records at RSUP Dr. M. Djamil Padang. Echocardiographic parameters were analyzed using appropriate statistical tests based on data distribution and type, including Chi-square, Fisher’s exact, and Mann-Whitney U tests. Results Significant differences were observed between PAH and PVH groups in terms of tricuspid regurgitation (TR) severity (p = 0.003), tricuspid annular plane systolic excursion (TAPSE) (p = 0.013), and tissue Doppler-derived systolic velocity of the tricuspid annulus (S′) (p = 0.001). No significant differences were found in ejection fraction (EF), systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP), or TR velocity (TR Vmax). Overall, RV systolic function differed significantly between the PAH and PVH groups (p = 0.006). Conclusions The findings demonstrate a statistically significant difference in RV systolic function between patients with PAH and PVH. These results underscore the need for more comprehensive and routine echocardiographic evaluation of RV function in these populations to enhance risk stratification and management.
Potensi Pemanfaatan Serum Mir 122-5p Sebagai Biomarker Dalam Deteksi Dini Infark Miokard Akut Pada Pasien Lanjut Usia Siregar, Muhammad Abi Ghoffari; Hidayat, Fariz; Rayhansyah, Vito
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 2 (2024): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 2 Periode O
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i2.529

Abstract

Acute myocardial infarction is the first manifestation of CAD which is the leading cause of death worldwide. The increasing incidence is often associated with increasing age where eldery are mostly affected with this disease. Although there are several biomarkers such as troponin I and T in detecting the risk of developing AMI, it has been found that populations over 70 years have elevated troponin I levels and increased troponin T levels in non-AMI cases. Because of that, a specific biomarker that can specifically detect AMI is needed. This literature review is aimed to discuss the possibility by using miR-122-5p serum for specific biomarker in detecting AMI in eldery population. The literature search was conducted based on journal searching related to the topic such as, PubMed, Science Direct, and Google Scholar. Based on the literature research we have done and our topic, we have obtained the results as follows. Pathogenesis of AMI, the underlying mechanism of miR-122-5p in association with AMI, the specificity of miR-122-5p for AMI, and the comparison of miR-122-5p with other AMI biomarkers. From the pathogenesis of AMI, we have obtained the basis of the disease, the underlying mechanism explains the potential relation to AMI and the detection, through the specificity we can see how it may be effective as a biomarker, and the comparison may reveal it’s potential and how it compares to other biomarkers.
Co-Authors Fariz Hidayat, Fariz Gusti Revilla Linosefa Linosefa Miftah Irramah Rita Hamdani Siregar, Muhammad Abi Ghoffari Yanni, Mefri