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In Silico Study of Curcuminoid Compounds in Turmeric ( Curcuma longa) Plants as Halal Anticoagulant Active Ingredients Dewi, Tanaya Jati Dharma; Sya'bana, Mohammad Mohammad Ihda Faiz; Wafi, Abdul; Ma’arif, Burhan; Muchlasi, Luthfi Ahmad
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.24568

Background: Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin compound in turmeric is known to have the ability as an anticoagulant drug by inhibiting the formation of factor Xa by factor X. Objectif :This study aims to predict physicochemical properties, predict toxicity, and predict the antiviral activity of 8 curcumin-derived compounds in turmeric against antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF). Methods :Prediction of physicochemical properties is carried out using the SwissADME application and referring to Lipinski's five laws . Furthermore, the toxicity class was carried out using the pkCSM Online Tool and Protox Online Tool applications. Prediction of the antiviral activity of compounds was carried out using the Molegro Virtual Docker (MVD) application.Results:The results of the LD50 value and the classification of toxicity classes were classified according to GHS. 8 compounds derived from curcumin belong to toxicity classes 4 and 5. Antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF were said to be valid because they had RMSD values below 2 Å. Conclusion :The results showed that cyclocurcumin compounds were predicted to have good potential anticoagulant activity.Background: Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin compound in turmeric is known to have the ability as an anticoagulant drug by inhibiting the formation of factor Xa by factor X. Objectif :This study aims to predict physicochemical properties, predict toxicity, and predict the antiviral activity of 8 curcumin-derived compounds in turmeric against antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF). Methods :Prediction of physicochemical properties is carried out using the SwissADME application and referring to Lipinski's five laws . Furthermore, the toxicity class was carried out using the pkCSM Online Tool and Protox Online Tool applications. Prediction of the antiviral activity of compounds was carried out using the Molegro Virtual Docker (MVD) application.Results:The results of the LD50 value and the classification of toxicity classes were classified according to GHS. 8 compounds derived from curcumin belong to toxicity classes 4 and 5. Antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF were said to be valid because they had RMSD values below 2 Å. Conclusion :The results showed that cyclocurcumin compounds were predicted to have good potential anticoagulant activity.

The Compounds Activity of Black Potato (Plectranthus rotundifolius) as an Antioxidant Nutraceutical: - Natasya, Cindy; Safrina, Maureta E. R.; Ningrum, Salsabila E. S.; Fitriyani; Zahra, Lisa A.; Ma’arif, Burhan
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.1

Black potato (Plectranthus rotundifolius) is one of the horticultural plants that has potential as nutraceutical food and also contain bioactive compounds such as being rich in flavonoids, especially anthocyanins. The potential benefits of black potatoes are not widely known by public, so it is necessary to cultivate one of them by processing it into food such as instant porridge, which is then labeled as B-PORIS product. The reason for choosing instant porridge was because it is a practical food product. This research aimed to prove that instant porridge from black potato contains bioactive compounds flavonoids, especially anthocyanins. These instant porridges are made with the appropriate ratio in 3 formulations with different parameters of black potato flour concentration, formulation 1 10%, formulation 2 9%, and formulation 3 11%. This research was conducted with organoleptic tests, moisture content tests, flavonoids, anthocyanins, and hedonic tests. The results of the organoleptic test obtained soft texture, characteristic chocolate smell, brown color, and slightly sweet and sweeter taste. The results of moisture content test were qualified with water content of not more than 7%. The results of flavonoid and anthocyanin test obtained positive results in all of formulations. The hedonic test result 80-90% of panelists indicate choose an option like, and really like in questionnaires, results demonstrated that formulation 3 was most likely. So it can be concluded that black potato tubers has the potential to become a nutraceutical product as an instant porridge with antioxidant effect that received and liked by various groups of age.

(2,2-Diphenyl-1-picrylhydrazyl) ASSAY of KENIKIR LEAVES (C. caudatus K.), BELUNTAS LEAVES (Pluchea indica L.), AND PURPLE CORN (Zea mays) AS A SOURCE OF ANTIOXIDANTS Riwanti, Pramudita; Dewi Pinangkaan, Hanifah Mutiara; Mujib, Naili Nabila; Eka Putri, Safira Dinda; Ma’arif, Burhan
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.9275

The purpose of this study is to assess and compare the antioxidant activity of the ethanol extract and ethyl acetate fraction of the leaves of Kenikir (C. caudatus K.), Beluntas (Pluchea indica L.), and purple corn seed (Zea mays L.) in an effort to find new sources of antioxidants. The samples were extracted with a 96% ethanol as the solvent. Afterward, the extract was separated using n-hexane and ethyl acetate to get ethyl acetate fraction. The antioxidant concentration was determined using the DPPH free radical technique using spectrophotometer UV-Vis. The results indicate that the purple corn's ethyl acetate fraction has the highest antioxidant activity as a free-radical scavenger, with an IC50 value of 10.47 . The ethyl acetate fraction of P. indica leaves, the P. indica 96% ethanol extract, the C. caudatus leaves 96% ethanol extract, the purple corn's 96% ethanol extract, and the P. indica 96% ethanol extract are all listed after that. The purple corn's 96% ethanol extract has an IC50 value of 21.80 . According to these findings, purple corn has the highest antioxidant activity and may be a new source of antioxidants.

The Compounds Activity of Black Potato (Plectranthus rotundifolius) as an Antioxidant Nutraceutical: - Natasya, Cindy; Safrina, Maureta E. R.; Ningrum, Salsabila E. S.; Fitriyani; Zahra, Lisa A.; Ma’arif, Burhan
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.1

Black potato (Plectranthus rotundifolius) is one of the horticultural plants that has potential as nutraceutical food and also contain bioactive compounds such as being rich in flavonoids, especially anthocyanins. The potential benefits of black potatoes are not widely known by public, so it is necessary to cultivate one of them by processing it into food such as instant porridge, which is then labeled as B-PORIS product. The reason for choosing instant porridge was because it is a practical food product. This research aimed to prove that instant porridge from black potato contains bioactive compounds flavonoids, especially anthocyanins. These instant porridges are made with the appropriate ratio in 3 formulations with different parameters of black potato flour concentration, formulation 1 10%, formulation 2 9%, and formulation 3 11%. This research was conducted with organoleptic tests, moisture content tests, flavonoids, anthocyanins, and hedonic tests. The results of the organoleptic test obtained soft texture, characteristic chocolate smell, brown color, and slightly sweet and sweeter taste. The results of moisture content test were qualified with water content of not more than 7%. The results of flavonoid and anthocyanin test obtained positive results in all of formulations. The hedonic test result 80-90% of panelists indicate choose an option like, and really like in questionnaires, results demonstrated that formulation 3 was most likely. So it can be concluded that black potato tubers has the potential to become a nutraceutical product as an instant porridge with antioxidant effect that received and liked by various groups of age.

Identification Of Escherichia Coli Bacterial Contamination in Home Industry Baby Porridge In The Malang City Area Dafin, Anis Akhwan; Putri, Elsa Mahardika; Prasetyawan, Fendy; Muslikh, Faisal Akhmal; Ma’arif, Burhan; Megawati, Dewi Sinta
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7269

Growth and development in toddlers is very important, especially the nutritional needs of toddlers. MP-ASI is additional food to provide sufficient nutrition for babies. MP-ASI is divided into two types, namely traditional and industrial. Traditional MP-ASI is baby porridge that is prepared by yourself and sold on the side of the road. Hygiene and sanitation in roadside food can have a negative impact on consumers, especially bacterial contamination of food, one of which is Coliform bacteria, Escherichia Coli, etc. The method for calculating and estimating the number of E. coli bacteria found in chicken meat in this study used the Most Probable Number (MPN). The results showed that of the 4 samples tested, 3 were contaminated with E. Coli bacteria and 1 was negative for E. Coli bacterial contamination

Optimasi Kombinasi Ramuan Etnomedisin Penumbuh Rambut Nusa Tenggara Timur Menggunakan Orthogonal Stimulus Response Method Pada Kepadatan Rambut Mencit (Mus musculus) Taek, Maximus M.; Megawati, Dewi Sinta; Subiyakto, Erlangga Sufi; Khoirunnisa, Zahra; Maulina, Novia; Muslikh, Faisal Akhmal; Ma’arif, Burhan
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 4 (2025): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i4.18301

This study aimed to optimize a traditional ethnomedicinal formulation from East Nusa Tenggara (RENTT) as a natural hair-growth candidate and to evaluate its antioxidant activity and biological effectiveness using an alopecia model. A true experimental design was applied using the Taguchi–Orthogonal Stimulus Response Method (OSRM) to determine the optimal combination of five plant extracts, namely Aleurites moluccanus, Hibiscus rosa-sinensis, Ficus benjamina, Polyscias scutellaria, and Hibiscus tiliaceus. In vitro optimization was conducted using the DPPH radical scavenging assay with a Taguchi L27 orthogonal array design. The optimal formulation was subsequently evaluated in vivo using male mice (Mus musculus) with croton oil–induced alopecia. Hair growth effectiveness was assessed based on hair density percentage through histomorphometric analysis with hematoxylin–eosin staining. The results demonstrated that the optimal RENTT formulation exhibited very strong antioxidant activity with an IC₅₀ value of 27.46 ppm. Taguchi analysis identified F. benjamina as the most influential factor in determining formulation performance. In vivo evaluation showed that the RENTT-treated group achieved the highest hair density (49.45 ± 4.70), which was significantly higher than that of the positive control, negative control, and normal control groups. In conclusion, the optimized RENTT formulation demonstrates strong antioxidant properties and a significant stimulatory effect on hair growth, indicating its promising potential as a natural cosmeceutical product based on the local wisdom of East Nusa Tenggara.

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