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All Journal Jurnal Kelautan Tropis Journal of Islamic Pharmacy ad-Dawaa : Journal of Pharmaceutical Sciences Science Midwifery Journal of Pharmaceutical Care Anwar Medika Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Farmasi Sains dan Praktis Journal of Pharmacy Science and Technology JPMP Acta Holistica Pharmaciana Borneo Journal of Pharmacy Indonesian Journal of Jamu
Pramudita Riwanti
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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CHARACTERIZATION OF MELOXICAM AND MALONIC ACID COCRYSTAL PREPARED WITH SLURRY METHOD Najih, Yuli Ainun; Widjaja, Bambang; Riwanti, Pramudita; Mu'alim, Ade Ianaini
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6140

Abstract

Meloxicam (MLX) is a nonsteroidal anti-inflammatory drugs (NSAID) which belong to Biopharmaceutical Classification System (BCS) class II, which have a low solubility level with a high permeability. Therefore, to enchance is solubility level, physical modification of the meloxicam is required. It  can be done by the cocrystal formation. Cocrystal contained active ingredients and coformer which bind through the hydrogen bond. This study used malonic acid (MA), since it contained carboxylic group which expected to form hydrogen bonds. Slurry is a method of cocrystal formation by mixing two ingredients, i.e. active ingredients of the drugs and its cofomer, dissolved in a solvent and may be formed due to the heat energy released by the friction between particles and their crusher. This study aimed to determine the characteristic of meloxicam-malonid acid cocrystal by 1:1 mol ratio using PXRD, DSC and FTIR. The result of PXRD charaterization indicated a new peak at angle 9,4° and 18,5°. The result of DSC characterization indicated an endothermic peak with a low melting point at 97,64°C ; 152,62°C ; 176,87°C temperature. The result of FTIR characterization indicated a shirt of the O-H uptake band from at wave number 3126-2980 cm-1 to 3292-2951 cm-1, the N-H uptake band of meloxicam at wave number 3492 cm-1 to 3525 cm-1
Pengaruh Perbedaan Konsentrasi Etanol pada Kadar Flavonoid Total Ekstrak Etanol 50,70 dan 96% Sargassum polycystum dari Madura Riwanti, Pramudita; Izazih, Farizah; Amaliyah, Amaliyah
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 2 No 2 (2020): Volume 2, Nomor 2, Juni 2020
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (726.432 KB) | DOI: 10.36932/jpcam.v2i2.1

Abstract

Sargassum polycystum merupakan jenis rumput laut coklat yang sangat berpotensi untuk dimanfaatkan karena mengandung senyawa flavonoid yang berfungsi sebagai antioksidan dan mempunyai bioaktivitas sebagai obat. Analisis kadar flavonoid total dalam Sargassum polycystum perlu dilakukan untuk menjamin kualitas serta keamanan suatu bahan obat. Salah satu faktor yang berpengaruh terhadap perolehan kadar flavonoid total adalah konsentrasi pelarut sehingga dalam penelitian ini digunakan pelarut etanol 50%, 70% dan 96% yang bertujuan untuk mengetahui konsentrasi pelarut etanol yang paling optimal dalam mendapatkan kadar flavonoid total Sargassum polycystum menggunakan Metode Spektrofotometri UV-Vis dengan pembanding kuersetin. Metode tersebut perlu di validasi yang terdiri dari selektivitas, linearitas, presisi dan akurasi. Hasil selektivitas didapatkan λmaks yaitu 435,50 nm. Hasil linearitas diperoleh persamaan y=0,0763x-0,0790 dengan nilai r= 0,9936. Hasil presisi diperoleh % RSD yaitu 0,998% dan hasil % Recovery ekstrak etanol 50% adalah 100,4856%; ekstrak etanol 70% adalah 77,2643% dan ekstrak etanol 96% adalah 83,5053%. Kadar flavonoid total yang diperoleh untuk ekstrak etanol 50%, 70% dan 96% berturut-turut adalah 0,0539%b/b, 01300%b/b dan 0,1180%b/b sehingga dapat disimpulkan bahwa kadar flavonoid total tertinggi terdapat pada ekstrak etanol 70%. Berdasarkan uji Kruskall Wallis diperoleh nilai signifikansi 0,027 (P<0,05) artinya terdapat pengaruh konsentrasi pelarut etanol terhadap kadar flavonoid total yang diperoleh.
Uji Aktivitas Antibakteri Sargassum polycystum terhadap Bakteri Staphylococcus aureus Riwanti, Pramudita; Andayani, Rina; Trinanda, Lia
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.199

Abstract

Penelitian ini bertujuan mengetahui aktivitas antibakteri ekstrak etanol 96% Sargassum polycystumterhadap bakteri Staphylococcus aureus. S.polycystumdiperoleh dariDesa Cabbiya, Kecamatan Talango, Kabupaten Sumenep, Madurayang diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Penelitian ini dilakukan dengan 5 perlakuan dan 3 kali replikasi. Masing-masing perlakuan terdiri atas ekstrak etanol 96% rumput laut coklat S. polycystumdengan konsentrasi 10% b/v, 20% b/v, 40% b/v, 80% b/v dan 100% b/v, kontrol positif yang digunakan adalah kloramfenikol 0,1%, dan kontrol negatif yang digunakan adalah pelarut yaitu etanol 96% yang digunakan sebagai pelarut ekstrak. Uji antibakteri ekstrak etanol 96% S. polycystummengunakan metode sumuran dengan jumlah bakteri yang disesuaikan dengan standar kekeruhan Mc Farland. Data yang diperoleh dianalisis statistik SPSS dengan metode One-way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak etanol 96% rumput laut coklat S. polycystummempunyai aktivitas antibakteri terhadap S. aureus. Hasil pengukuran zona hambat yang diperoleh pada konsentrasi 10% sebesar 3,49 ± 3,55 mm; konsentrasi 20% sebesar 4,22 ± 3,91 mm; konsentrasi 40% sebesar 5,97 ± 5,09mm; konsentrasi 80% sebesar 8,41 ± 2,76 mm; dan konsentrasi 100% sebesar 11,07 ±0,07mm.
Aktivitas Antibakteri Ekstrak Metanol Kulit Batang Rhizophora mucronata Poiret terhadap Salmonella thypi, Lignières 1900 (Enterobacteriaceae : Gammaproteobacteria) Mahmiah Mahmiah; Serdian Pinaris Rama; Pramudita Riwanti
Jurnal Kelautan Tropis Vol 23, No 2 (2020): JURNAL KELAUTAN TROPIS
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkt.v23i2.5577

Abstract

Typhoid fever is an acute infectious disease of the small intestine caused by Salmonella typhi or Salmonella paratyphi A, B and C. Antibiotics commonly used for Salmonella infections are fluoroquinolones and tetracyclines. However, Salmonella has been resistant to these antibiotics. The many occurrences of antibiotic resistance encourage researchers to find solutions. Rhizophora mucronata is a mangrove from the family Rhizophoraceae. Phytochemically, Rhizophora mucronata is rich in many kinds of compounds such as tannins, alkaloids, flavanoids, terpenoids and saponins which important in suppressing pathogenic microorganisms. This study aims to determine the antibacterial activity of methanol extract of Rhizophora mucronata bark against the growth of Salmonella typhi bacteria looked at the clear zone around the well. This research is an experimental laboratory study using the well diffusion method. Rhizophora mucronata bark samples were extracted by maceration method. The results is the inhibition zone diameter methanol extract of Rhizophora mucronata bark with concentrations of 20%, 40%, 60% and 80% (b / v) classified as moderate (9.22 mm) to strong (13.78 mm) , the greater the concentration, the greater the diameter of the inhibition zone.  Demam tifoid adalah penyakit infeksi akut usus halus yang disebabkan oleh bakteri Salmonella typhi atau Salmonella paratyphi A, B dan C. Antibiotik yang umum digunakan dalam penatalaksanaan infeksi bakteri yang disebabkan oleh bakteri Salmonella adalah fluoroquinolones dan tetrasiklin. Akan tetapi, Salmonella telah mengalami resisten terhadap antibiotik tersebut. Rhizophora mucronata merupakan mangrove dari famili Rhizophoraceae. Secara fitokimia, Rhizophora mucronata kaya dengan beberapa macam senyawa seperti tannin, alkaloid, flavanoid, terpenoid dan saponin yang berperan penting dalam menekan mikroorganisme patogen. Penelitian ini bertujuan untuk menentukan aktivitas antibakteri ekstrak metanol kulit batang Rhizophora mucronata terhadap pertumbuhan bakteri Salmonella typhi dengan melihat adanya zona bening disekitar sumuran. Penelitian ini merupakan penelitian eksperimental laboratories dengan menggunakan metode difusi sumuran. Sampel kulit batang Rhizophora mucronata dilakukan ekstraksi dengan metode maserasi. Hasil penelitian menunjukkan bahwa diameter zona hambat yang dihasilkan oleh ekstrak metanol kulit batang Rhizophora mucronata dengan konsentrasi 20 %, 40 %, 60 % dan 80 % (b/v) tergolong sedang (9,22 mm) hingga kuat (13,78 mm), semakin besar kosentrasi maka semakin besar juga diameter zona hambatnya.
STUDI IN SILICO DAN HUBUNGAN KUANTITATIF STRUKTUR TERHADAP AKTIVITAS TANAMAN MANGROVE (Avicennia marina (Forssk.) Vierh.) SEBAGAI ANTIDIABETES Arinil Hidayati; Siswandono Siswandono; Pramudita Riwanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 2 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v2i1.98

Abstract

The research is applied to 20 compounds contained into Avicennia marina which is : 4',5-dihydroxy-3',5',7-trimethoxyflavone, isorhamnetin 3-O-rutinoside, quercetin, stenocarproquinone B, avicennone C, avicennone E, avicennone F, avicennone D, 4'5-dihydroxy-3',7-dimethoxyflavone, chrysoeriol 7-O-glucoside, naphta(1,2-b)furan-4,5-dione, 3-hydroxy-naphtal (1,2-b)furan-4,5-dione, kaempferol, 5-hydroxy-4',7-dimethoxyflavone, avicequinone C, 2-[2'-(2'-hydroxy)propyl]-naphta[1,2-b]furan-4,5-dione,4',5,7-trihydroxyflavone, luteolin 7-O-methylether, luteolin 7O-methylether 3'-O-beta-D-glucoside,5,7-dihidroxy-3',4',5'-trimethoxyflavone which are expected to have an effect as antidiabetics agent. It is undertaken to find out the linier or nonlinier relationship of the structure activity (QSAR), the physicochemical characters (lipophilic, electronic, and steric) to the activitychanging (rerank score). Moreover, it is also undertaken to find out which one of those 20 Avicenia marina compounds are predicted to possess the activity as the best antidiabetics agent by the comparison of pioglitazon. It is arranged through computerized methods through some progrmas such as used to make prediction of the activity by using Molegro Virtual Docker 20`11.5.0.0 from CLCBio. by using the peroxisome proliferator-activated receptor-gamma (PPAR) in code of PDB : 2XKW. The compound of isorhamnetin 3-O-rutinoside, , chrysoeriol 7-O-glucoside, dan senyawa luteolin 7-O-methylether 3'-O-beta-D-glucosdie are predicted to have the best antidiabetics agent if it is compared with comparing drug pioglitazon.
DETEKSI DINI FAKTOR RISIKO DAN EDUKASI KESEHATAN PENYAKIT TIDAK MENULAR PADA MASYARAKAT DUSUN TLOCOR DESA KEDUNGPANDAN KECAMATAN JABON KABUPATEN SIDOARJO Ronald Pratama A.; Riami; Tamam Jauhar; Pramudita Riwanti; Sylvia Rizki; Ersanda Nurma; Astrid Kusuma
Jurnal Pengabdian Masyarakat Pesisir VOLUME 1 NO 2
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v1i2.82

Abstract

Penyakit Tidak Menular (PTM) masih merupakan masalah kesehatan yang menjadi penyebab tingginya angka kesakitan dan kematian di dunia pada umumnya dan di Indonesia pada khususnya. PTM khususnya hipertensi dan diabetes mellitus seringkali berujung pada komplikasi antara lain penyakit jantung, gagal ginjal dan menjadi penyumbang yang signifikan beban pembiayaan kesehatan di Indonesia sehingga merupakan suatu hal yang penting untuk mengendalikan faktor-faktor risiko yang memicu terjangkitnya PTM. Pengetahuan akan faktor risiko penyebab timbulnya PTM, dan kesadaran untuk melakukan upaya-upaya pencegahan PTM dengan mengendalikan faktor-faktor risiko tersebut serta rutin memeriksakan kesehatan secara berkala adalah hal yang penting dalam keberhasilan mengendalikan PTM. Masyarakat di Dusun Tlocor, Desa Kedungpandan, Kecamatan Jabon, Kabupaten Sidoarjo merupakan kelompok masyarakat yang terdampak akibat dari semburan lumpur Lapindo menyebabkan tempat pemukimannya direlokasikan. Fasilitas pelayanan kesehatan yang relatif jauh dari tempat tinggal, ditambah dengan kurangnya kesadaran dan pengetahuan masyarakat tersebut akan PTM dan upaya pengendaliannya ditunjukkan dengan tingginya kasus hipertensi dan diabetes mellitus sehingga dilaksanakan kegiatan pengabdian masyarakat berupa deteksi dini faktor risiko dan edukasi kesehatan pencegahan PTM.
Metabolite Profiling of the Environmental-Controlled Growth of Marsilea crenata Presl. and Its In Vitro and In Silico Antineuroinflammatory Properties Burhan Ma'arif; Faisal Akhmal Muslikh; Dilla Amalia; Anisah Mahardiani; Luthfi Achmad Muchlasi; Pramudita Riwanti; Maximus Markus Taek; Hening Laswati; Mangestuti Agil
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3262

Abstract

This study was aimed to evaluate the metabolite contents and antineuroinflammatory potential of Marsilea crenata Presl. grown under a controlled environmental condition. The antineuroinflammatory test has been carried out in vitro using ethanolic extract of M. crenata leaves on HMC3 microglia cells. An in silico approach was applied to predict the active compounds of the extract. The HMC3 microglia cells were induced with IFNγ to create prolonged inflammatory conditions and then treated with 96% ethanolic extract of the M. crenata leaves of 62.5, 125, and 250 μg/mL. The expression of MHC II was analyzed using the ICC method with the CLSM instrument. Metabolites of the extract were profiled using UPLC-QToF-MS/MS instrument and MassLynx 4.1 software. In silico evaluation was conducted with molecular docking on 3OLS protein using PyRx 0.8 software, and physicochemical properties of the compounds were analyzed using SwissADME webtool. The ethanolic extract of M. crenata leaves could reduce the MHC II expression in HMC3 microglia cells in all concentrations with the values 97.458, 139.574, and 82.128 AU. The result of metabolite profiling found 79 compounds in the extract. In silico evaluation showed that 19 compounds gave agonist interaction toward 3OLS, and three met all parameters of physicochemical analysis. The ethanolic extract of the environmental-controlled growth of M. crenata leaves antineuroinflammatory activity on HMC3 microglia cells. The extract was predicted to contain some phytoestrogen compounds which act as 3OLS agonists.
SKRINING FITOKIMIA EKSTRAK ETANOL 96% SARGASSUM POLYCYSTUM DAN PROFILE DENGAN SPEKTROFOTOMETRI INFRARED Riwanti, Pramudita
Acta Holistica Pharmaciana Vol 1 No 2 (2019): Acta Holistica Pharmaciana
Publisher : School of Pharmacy Mahaganesha (Sekolah Tinggi Farmasi Mahaganesha)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62857/ahp.v1i2.17

Abstract

Kandungan kimia yang terdapat dalam tumbuhan mengambil peran dalam memberi aktivitas farmakologi yang berbeda sehingga penelitian ini dilakukan untuk mengembangkan pemanfaatan rumput laut Sargassum polycystumdengan melakukan skrining fitokimia. Skrining fitokimia bertujuan memberikan gambaran tentang golongan senyawa yang terkandung dalam tanaman. Dalam penelitian ini digunakan Sargassum polycystumyang diambil dari daerah Sumenep, Madura. Ekstrak dibuat dengan mengekstraksi simplisia S.polycystumdengan pelarut etanol 96% menggunakan metode maserasi dan perbandingan pelarut dan serbuk yaitu 1:4. Hasil uji skrining menunjukkan bahwa S.polycystumpositif mengandung senyawa golongan alkaloid, glikosida, steroid/triterpenoid, saponin, flavanoid, polifenol, dan tanin. Hasil profiling dengan FTIR juga menunjukkan adanya gugus fungsi senyawa aromatik, karbonil, alifatik dan alcohol.
(2,2-Diphenyl-1-picrylhydrazyl) ASSAY of KENIKIR LEAVES (C. caudatus K.), BELUNTAS LEAVES (Pluchea indica L.), AND PURPLE CORN (Zea mays) AS A SOURCE OF ANTIOXIDANTS Riwanti, Pramudita; Dewi Pinangkaan, Hanifah Mutiara; Mujib, Naili Nabila; Eka Putri, Safira Dinda; Ma’arif, Burhan
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.9275

Abstract

The purpose of this study is to assess and compare the antioxidant activity of the ethanol extract and ethyl acetate fraction of the leaves of Kenikir (C. caudatus K.), Beluntas (Pluchea indica L.), and purple corn seed (Zea mays L.) in an effort to find new sources of antioxidants. The samples were extracted with a 96% ethanol as the solvent. Afterward, the extract was separated using n-hexane and ethyl acetate to get ethyl acetate fraction. The antioxidant concentration was determined using the DPPH free radical technique using spectrophotometer UV-Vis. The results indicate that the purple corn's ethyl acetate fraction has the highest antioxidant activity as a free-radical scavenger, with an IC50 value of 10.47 . The ethyl acetate fraction of P. indica leaves, the P. indica 96% ethanol extract, the C. caudatus leaves 96% ethanol extract, the purple corn's 96% ethanol extract, and the P. indica 96% ethanol extract are all listed after that. The purple corn's 96% ethanol extract has an IC50 value of 21.80 . According to these findings, purple corn has the highest antioxidant activity and may be a new source of antioxidants.
Standardization of 96% Ethanol Extract of Beluntas Leaves, Kenikir Leaves, and Purple Corn Kernels Riwanti, Pramudita; Ma'arif, Burhan; Primadini, Filicia Regya; Maulidiah, Erika Nur; Ramadhan, Ravy Irsyad
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.312

Abstract

Beluntas (Pluchea indica) leaves, kenikir (Cosmos caudatus) leaves, and purple corn (Zea mays) kernels have the potential to be developed into preparations of traditional medicine, which requires standardization of raw materials. The 96% ethanol extract P. indica leaves from Batu, C. caudatus leaves from Wonosari, and purple corn kernels from Sukabumi have been standardized. Both specific and non-specific requirements are covered. Fragment identifiers of P. indica leaves, such as stomata and trichoma. C. caudatus leaves, such as vascular tissue with stair thickening and multicellular hair covering. Purple corn kernels such as amylum and hilum in the form of stars. The thick extracts were obtained from the results of ultrasonic-assisted extraction with yields of 14.76% for P. indica leaves, 7.49% for C. caudatus leaves, and 5.79% for purple corn kernels. The organoleptic of ethanolic extract P. indica leaves is thick and greenish-black, C. caudatus leaves is thick and brown, and purple corn kernels is thick and purple. The water-soluble content from P. indica leaves, C. caudatus leaves, and purple corn kernels was 13.85%, 11.13%, and 10.62%, respectively. The ethanol soluble content was 16.58%, 14.87%, and 15.89%. The total ash content for P. indica leaves, C. caudatus leaves, and purple corn kernels was 15.04%, 9.37%, and 4.76%. The percentage of water content was 9.07%, 14.34%, and 11.12%. The standardized data collected was compared with the requirements in the official monographs of Materia Medika Indonesia and Farmakope Herbal Indonesia. The results showed that the three samples used had met most of the standardization parameters and could be developed into traditional medicine.
Co-Authors Alrayan, Reza Amaliyah, Amaliyah Anisah Mahardiani Arinil Hidayati Astrid Kusuma Bambang Widjaja Burhan Ma'arif Dewi Pinangkaan, Hanifah Mutiara Dilla Amalia Eka Putri, Safira Dinda Ersanda Nurma Faisal Akhmal Muslikh Hening Laswati Putra Izazih, Farizah Juniar, Kiki Luthfi Achmad Muchlasi Ma'arif, Burhan Mahmiah Mahmiah Mahmiah Mangestuti Agil Maulidiah, Erika Nur Maximus M Taek Ma’arif, Burhan Mu'alim, Ade Ianaini Mujib, Naili Nabila Najih, Yuli Ainun Primadini, Filicia Regya Ramadhan, Ravy Irsyad Riami Rina Andayani, Rina Ronald Pratama Adiwinoto Serdian Pinaris Rama Siswandono, Siswandono Sylvia Rizki Tamam Jauhar Trinanda, Lia