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All Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Narra J
Sofyantoro, Fajar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Pemanfaatan Eco-Enzyme sebagai Pestisida Alami dan Solusi Pengelolaan Limbah di Sulobaja, Mamuju Tengah: Utilization of Eco-Enzyme as a Natural Pesticide and a Solution for Waste Management in Sulobaja, Mamuju Tengah Aristya, Ganies Riza; Safitri, Della Thasya Liona; Utami, Mia; Syafei, Dio Rachmaputra; Dewi, Umi Rosita; Abiyyi, Muhammad Hawi Qabus; Muhammada, Khusnus Syifa; Ulfa, Siti Zakia; Sofyantoro, Fajar
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 5 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i5.9156

Abstract

Sulobaja Village, located in Tobadak District, Mamuju Tengah Regency, faces significant challenges in managing household organic waste, which is often discarded indiscriminately or burned, leading to environmental pollution and reduced water quality. This community service program aimed to enhance public awareness and skills in organic waste management through the production of eco-enzyme, a liquid derived from fermenting organic waste that can be used as a natural cleaner, liquid fertilizer, and pesticide. The program included several stages: initial observation, socialization, hands-on practice, evaluation, and follow-up. Socialization was conducted through educational sessions at the Sulobaja Village Hall, followed by practical training on producing eco-enzyme using household organic waste, molasses, and water. After one month of fermentation, the resulting eco-enzyme exhibited a dark brown color and a distinct acidic aroma, indicating a successful fermentation process. Participants showed a high level of enthusiasm, with over 70% expressing their willingness to continue production independently. The program successfully reduced household organic waste, improved soil fertility, and decreased the use of chemical-based household products. Furthermore, it encouraged the establishment of small production groups to ensure program sustainability. The results demonstrate that eco-enzyme production can serve as a practical and sustainable solution for organic waste management while providing economic and environmental benefits to the community. This program is expected to be replicated in other villages as a model for environmentally friendly waste management.
Comparative analysis of hemotoxic, myotoxic, and inflammatory profiles of Calloselasma rhodostoma and Trimeresurus insularis venoms in mice Aphrodita, Adiva; Sentono, Diva N.; Yudha, Donan S.; Purwestri, Yekti A.; Nuringtyas, Tri R.; Raharjo, Slamet; Wahid, Isra; Rahmi, Sri N.; Wahyudi, Setyanto T.; Sofyantoro, Fajar
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v5i2.1874

Abstract

Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as Calloselasma rhodostoma and Trimeresurus insularis are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of C. rhodostoma and T. insularis venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20–100 µg) of C. rhodostoma and T. insularis venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that C. rhodostoma venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, T. insularis venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with C. rhodostoma eliciting a stronger inflammatory response at lower doses.Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as Calloselasma rhodostoma and Trimeresurus insularis are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of C. rhodostoma and T. insularis venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20–100 µg) of C. rhodostoma and T. insularis venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that C. rhodostoma venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, T. insularis venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with C. rhodostoma eliciting a stronger inflammatory response at lower doses.
Co-Authors Abiyyi, Muhammad Hawi Qabus Aphrodita, Adiva Dewi, Umi Rosita Ganies Riza Aristya Isra Wahid Muhammada, Khusnus Syifa Nuringtyas, Tri R. Purwestri, Yekti A. Rahmi, Sri N. Safitri, Della Thasya Liona Sentono, Diva N. Slamet Raharjo Syafei, Dio Rachmaputra Ulfa, Siti Zakia Utami, Mia Wahyudi, Setyanto T. Yudha, Donan S.