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All Journal Biota JMM (Jurnal Masyarakat Mandiri) Rumphius Pattimura Biological Journal
Sofyantoro, Fajar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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Modulatory Effects of Fucoidan on Paracetamol-induced Hepatic Damage and Histological Alterations in Rasbora lateristriata Sofyantoro, Fajar; Dafa, Maula Haqul; Primahesa, Alfian; Oktaviana, Shintia; Mayani, Olvita; Simanungkalit, Eben Ezer; Prissandi, Anthera Al Firdaus; Nuriliani, Ardaning; Retnoaji, Bambang; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Wijayanti, Nastiti; Septriani, Nur Indah
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.27845

Abstract

Paracetamol overdose is a well-documented cause of hepatic injury across vertebrate species, including teleost fish. This study aimed to evaluate the hepatoprotective potential of fucoidan, a sulfated polysaccharide derived from brown algae, against paracetamol-induced liver damage in Rasbora lateristriata. Fish were divided into five experimental groups and exposed to paracetamol (3 mg/L), either alone or in combination with fucoidan at concentrations of 50, 100, or 300 µg/mL, for seven days. Histopathological evaluation of liver tissues was performed using hematoxylin–eosin staining, with semi-quantitative scoring focused on hydropic degeneration, nuclear pyknosis, and necrosis. The results demonstrated that paracetamol exposure induced moderate hepatocellular injury, characterized by cytoplasmic vacuolization, apoptotic nuclear alterations, and necrotic lesions. Co-treatment with fucoidan at 300 µg/mL was associated with reduced severity across all histopathological parameters, indicating partial hepatoprotective effects. In contrast, the 50 µg/mL fucoidan group exhibited paradoxically severe hydropic degeneration despite the absence of pyknosis and necrosis, suggesting a delayed or altered injury profile. Intermediate outcomes were observed at 100 µg/mL. Overall, fucoidan exhibited dose-dependent but inconsistent hepatoprotective effects. The observed histological variability across concentrations suggests that protection may be influenced by factors such as bioavailability, cellular uptake, or interactions with intracellular stress pathways. These findings highlight the need for further mechanistic investigations before fucoidan can be considered a reliable hepatoprotective agent in aquatic toxicology.
Histopathological Analysis of Liver Damage in Rasbora lateristriata Fish Induced by extract Butterfly Pea flower (Clitoria ternatea) Endar Pertiwi, Anggita; Illiyin, Sirayya; Sadewo, Imran; Rahayu, Sekar; Samparisna Rumansara, Papuani; Moli Podhi, Felisitas; Sularsah, Sais; Adelfiani, Adelfiani; Retnoaji, Bambang; Sofyantoro, Fajar; Nuriliani, Ardaning; Wijayanti, Nastiti; T.S.S.G. Saragih, Hendry; Rohmah, Zuliyati; Widiyanto, Slamet; Eka Putri Empra, Desi; Ariesti, Wiwin; Septriani, Nur Indah
RUMPHIUS Vol 8 No 1 (2026): RUMPHIUS Pattimura Biological Journal (in process)
Publisher : Universitas Pattimura

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Abstract

Butterfly pea flower (Clitoria ternatea) is an Indonesian native plant known for its medicinal properties due to its rich content of anthocyanins, flavonoids, and ternatins. Although widely recognized for its health benefits, the long-term effects of its bioactive compounds require careful evaluation. This study aimed to investigate the potential hepatotoxic effects of butterfly pea flower extract on the liver of Rasbora lateristriata fish. Fish were exposed to 0 (control), 50, 75, and 100 ppm of butterfly pea extract for four days, with four fish allocated per group. Histological markers, including necrosis, vacuolization, pyknosis, and hemorrhage, were assessed in liver tissues. Data were analyzed using the Kruskal-Wallis test and Mann-Whitney U test at a 95% confidence level. Results indicated that butterfly pea flower extract caused significant hepatic damage, with increased severity at higher concentrations. The most pronounced damage was observed at 75 ppm, suggesting an optimal dose for inducing oxidative stress. This study highlights the potential hepatotoxicity of butterfly pea flower extract in aquatic species and underscores the need for further research to evaluate its safety for therapeutic use.
PEMANFAATAN DAUN KELOR UNTUK PENINGKATAN KESEJAHTERAAN MASYARAKAT DI KULON PROGO Aristya, Ganies Riza; Salsabila, Sophia; Risydah, Fiqiha; Amadeus, Sovann; Akbar, Ananda Malik; Tasyarofa, Alya; Yuda, Khalid Abdillah Abdurahman; Dyanita, Anissa Cahyadevi; Sofyantoro, Fajar
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 3 (2024): Juni
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i3.22884

Abstract

Abstrak: Sebagian besar masyarakat Kulon Progo bekerja sebagai petani dan peternak. Padukuhan Gegunung di Kulon Progo memiliki tanah yang subur. Tanaman kelor kaya akan nutrisi, memiliki akar yang kuat, dan dapat dimanfaatkan sebagai alternatif pakan ternak. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat terkait budidaya kelor serta pemanfaatannya dalam kehidupan sehari-hari. Kelompok sasaran dan lembaga yang menjadi mitra adalah kelompok ibu-ibu PKK. Jumlah peserta yang menjadi sasaran dari program ini berjumlah sekitar 50 orang. Kegiatan pengabdian masyarakat terbagi dalam tiga tahap, yakni survei awal dan perizinan, sosialisasi dan pelatihan, serta monitoring dan evaluasi. Sosialisasi dan pelatihan dilakukan dengan pemberian materi, diskusi, dan praktek langsung serta ditutup dengan pembagian bibit tanaman kelor. Evaluasi dilakukan melalui observasi peserta, wawancara, dan pengisian angket. Melalui program pengabdian ini, masyarakat berhasil memahami manfaat penggunaan tanaman kelor dalam kehidupan sehari-hari dan sanggup untuk menanam kelor di lingkungan sekitar dengan bibit yang telah dibagikan. Abstract: The community of Kulon Progo primarily engages in farming and livestock breeding. Gegunung Village, with its fertile soil, is ideal for cultivating moringa plants, which are nutrient-rich and can serve as alternative livestock feed. Our community service team conducted an educational outreach on the cultivation and benefits of moringa to enhance local understanding and usage. The program targeted the PKK women's group, involving approximately 50 participants. It was divided into three phases: initial survey, socialization and training, and monitoring and evaluation. The socialization and training phase included educational materials, discussions, and hands-on practice, concluding with the distribution of moringa seeds. Evaluation was conducted through participant observation, interviews, and questionnaires. Through this community service program, participants gained a comprehensive understanding of the benefits of moringa plants in daily life and demonstrated the ability to cultivate moringa in their local environment using the distributed seeds.
Co-Authors Adelfiani, Adelfiani Akbar, Ananda Malik Amadeus, Sovann Ardaning Nuriliani Ariesti, Wiwin Bambang Retnoaji Dafa, Maula Haqul Dyanita, Anissa Cahyadevi Eka Putri Empra, Desi Endar Pertiwi, Anggita Ganies Riza Aristya Illiyin, Sirayya Mayani, Olvita Moli Podhi, Felisitas Nastiti Wijayanti Oktaviana, Shintia Primahesa, Alfian Prissandi, Anthera Al Firdaus Rahayu, Sekar Risydah, Fiqiha Rohmah, Zuliyati Sadewo, Imran Salsabila, Sophia Samparisna Rumansara, Papuani Saragih, Hendry T. S. S. G. Septriani, Nur Indah Simanungkalit, Eben Ezer Slamet Widiyanto Sularsah, Sais T.S.S.G. Saragih, Hendry Tasyarofa, Alya Yuda, Khalid Abdillah Abdurahman