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All Journal Majalah Obstetri dan Ginekologi Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Nusantara The Journal Of Medical School Sumatera Medical Journal Jurnal Syntax Fusion : Jurnal Nasional Indonesia Narra J
Ardiansyah, Edy
Fakultas Kedokteran USU
Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Residu Urine Pasca Total Vaginal Histerektomi setelah Pemberian Misoprostol di RSUP H. Adam Malik Medan Djaganata, Servin Pandu; Ardiansyah, Edy; Tala, M. Rhiza Z; Sihite, Herbert; Siregar, Henry Salim; Effendi, Iman Helmi
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 3 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction One of the late complications of total vaginal hysterectomy (TVH) commonly involves urinary tract, i.e urinary retention (21-87%). Treatment with misoprostol can prevent the occurrence of urinary retention.Methods This study was a retrospective descriptive study using secondary data from 5-year-(January 2010-December 2014) medical records at Adam Malik Hospital in patients that underwent TVH. Samples were collected by total sampling. Data were analysed using univariate and ANOVA bivariate analysis. The p-value was considered significant if p<0.05 with a confidence interval of 95%.Results A total of 66 patients underwent TVH with mean post voiding urine volume 30.71 ± 6.78 mL. Based on the age, one person, 6, and 59 people were alloted into the following groups: 30- 39 (1.51%), 40- 49 (9.09%), and ≥50 years old (89.39%), respectively. Each group showed no significant difference in post voiding urine volume (20 ml; 27.8 ± 6.58 ml; 31.18 ± 6.69 ml, sequentially). The mean residual urine obtained increased along with parity, but showed no significant difference (p> 0.05).Conclusion: In this study, urinary retention was not present in patients going for TVH treated misoprostol. There is no significant difference in mean post voiding urine volume by age and parity group.Keywords : Total Vaginal Hysterectomy (TVH); residual urine; misoprostol
The Comparison of Er α Expression Between Endometriosis with No Endometriosis Syafardi, D. Irsat; Siregar, Hendry Salim; Kaban, Yostoto B; Ardiansyah, Edy
Sumatera Medical Journal Vol. 2 No. 1 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (526.193 KB) | DOI: 10.32734/sumej.v2i1.714

Abstract

Estrogen receptors (ER) play an important role in mediating action. The ER α has a higher affinity for estrogen and the dominant form of the normal endometrium. A cross-sectional study from an ectopic tissue of endo-metriosis and normal was examined for immunohistochemistry. This research was conducted from November 2015 until the sample complete. The analysis was performed using Fisher Exact test, p <0.05 was considered to any difference of estrogen alpha receptor expression between endometriosis patients with no endometriosis. REα is more dominant in normal endometrium, whereas in the case of endometriosis in the presence of many negative expression of REα then the assumption that REβ is a receptor that many encountered. There is a dif-ference in the expression of REα between endometriosis with no endometriosis.
The Difference of Bax Protein Expression between Endometrioma and Ovarian Carcinoma Chandran Frinaldo Saragih; Riza Rivany; Mohamad Fauzie Sahil; Fadjrir Fadjrir; Edy Ardiansyah; Muhammad Rizki Yaznil; Munauwarus Sarirah
Molecular and Cellular Biomedical Sciences Vol 3, No 2 (2019)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (861.661 KB) | DOI: 10.21705/mcbs.v3i2.50

Abstract

Background: Endometriosis is a benign disease that has malignant properties such as genetic polymorphism, loss control of cell proliferation, infiltration, and local spread or to distant places. Several endometriosis studies linking endometrioma/ ovarian endometriosis with an increased risk of ovarian malignancy give rise to a transformation phenomenon of endometriotic cysts into malignancy. Bax is a pro apoptotic protein whose expression decreases in a malignancy. This decrease is related to the poor prognosis of endometrioma and ovarian carcinoma. This study was aimed to identify the expression and the difference of Bax expression between endometrioma and ovarian carcinoma.Materials and Methods: Fifty of paraffin blocks of endometrioma tissue and ovarian carcinoma (serous, mucinous, clear cell, and endometrioid type) were examined by immunohistochemical using Bondmax Full Automatic with specific monoclonal antibody to identify Bax expression. The difference of Bax expression score between endometrioma tissue and ovarian carcinoma was tested by Mann-Whitney test with significant value was set at p<0.05.Results: This study found that mean Bax expression score in endometrioma tissue and ovarian carcinoma was 3.88 and 3.72. No difference of Bax expression between endometrioma tissue and ovarian carcinoma (p>0.05). No difference of Bax expression between the clinical stages and histopathological types of ovarian carcinoma (p>0.05).Conclusion: There are no statistically significant difference in Bax protein expression in ovarian cancer and endometrioma.Keywords: Bax expression, endometrioma, ovarian carcinoma, apoptotic resistance 
Serological description of neonatal umbilical cord blood from pregnant women confirmed with positive COVID-19 by RT-PCR at Rumah Sakit Umum Pusat H. Adam Malik, Medan, Indonesia Benjamin Sihite; Makmur Sitepu; Khairani Sukatendel; Sarma Nursani Lumbanraja; Iman Helmi Effendi; Rizki Yaznil; Edy Ardiansyah
Majalah Obstetri & Ginekologi Vol. 30 No. 3 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I32022.128-133

Abstract

HIGHLIGHTS 1. COVID-19 raises concern in regard with its effect on pregnancy.2. The serological descriptions of umbilical cord of neonates born from mothers suffering from COVID-19 were identified.3. Most of the serology was non-reactive IgG and IgM, followed was reactive IgG and the least was the reactive IgM.   ABSTRACT Objective: To evaluate the serological description of the neonatal umbilical cord in COVID-19 mothers confirmed by RT-PCR at Rumah Sakit Umum Pusat (RSUP) H. Adam Malik Medan in January-June 2021. Materials and Methods: This study was an observational study with a case series approach where the cases were mothers infected with SARS CoV-2 confirmed by RT-PCR. The study was conducted at Universitas Sumatera Utara (USU) Hospital Laboratory and RSUP H. Adam Malik for 6 months, from January 2021 to June 2021. The data collected were analyzed using descriptive statistics. If the data were normally distributed, they were presented as mean + SD; otherwise, they were presented as median (min-max) for each variable. The Statistical Package for Social Sciences version 22.0 (IBM SPSS Corp.; Armonk, NY, USA) was used for statistical analysis. Results: Neonatal umbilical cord serology results (IgM and IgG) were predominantly non-reactive, where IgM was non-reactive in 43 neonates (97.7%) and IgG was non-reactive in 37 neonates (84.1%). In mothers without COVID-19 symptoms, neonate umbilical cord serology results were dominated by non-reactive IgM (88.6%) and IgG (79.5%). In mothers who recovered from COVID-19, neonate umbilical cord serology results were also dominated by non-reactive IgM (95.5%) and IgG (81.8%). Conclusion: The neonatal umbilical cord serology results from the mother confirmed with positive COVID-19 were nonreactive IgG and IgM in the majority of 35 (79%) samples, reactive IgG in 7 (15.9%), and reactive IgM in 1 (2%) sample.
Analisis Kejadian Plasenta Akreta di RSUP H. Adam Malik Medan Tahun 2016-2019 Dwi Putri, Savira; Helmi Effendi, Iman; Yulfi, Hemma; Ardiansyah, Edy
Jurnal Syntax Fusion Vol 2 No 10 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : CV RIFAINSTITUT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i02.173

Abstract

Placenta accreta is considered a life-threatening condition and is a cause of maternal death. Placenta accreta causes 7% -10% of cases of maternal mortality worldwide. Previous Sectio Ceasarea (SC) and uterine surgery are the most common risk factors for placenta accreta. Placenta accreta occurs when villous placenta invades directly into the myometrium. The incidence of placenta accreta increases with increasing incidence of SC. this wa is descriptive with a retrospective study. From 2016 – July 2019 there were 59 cases of placenta accrete with an increase in the number each year. Risk factor for the history of sectio ceasarea (94,8%). Sectio ceasarea + hysterectomy is a procedure of placenta accreta. There were no maternal mortality from 2016 – 2019 up to July. The annual incidence of placenta accreta increases each years mean risk factors dominant placenta accreta is history sectio ceasarea.
Role of estradiol and C-reactive protein levels on genitourinary syndrome in menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Tobing, Immanuel DL.; Lubis, Roni B.; Azmeila, Selly; Pasaribu, Hotma P.; Prabudi, Oky; Ardiansyah, Edy; Effendi, Iman H.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.626

Abstract

Menopause leads to decreased estradiol levels affecting tissue health and causing local inflammation in the genital organs and urinary tract. The rise of blood C-reactive protein (CRP) levels in menopausal women may indicate systemic inflammation associated with estradiol decline. The aim of this study was to determine the relationship between serum estradiol and CRP levels on genitourinary syndrome in menopausal women. A cross-sectional study was conducted among menopausal women who had not experienced menstruation for at least 12 consecutive months at Prof. dr. Chairuddin P. Lubis Hospital, Medan, Indonesia, in 2023. Estradiol and CRP levels were measured using enzyme-linked immunosorbent assay (ELISA) and the presence of genitourinary syndrome was assessed using the Menopause-Specific Quality of Life (MENQOL) questionnaire. The mean levels of estradiol and CRP were compared to menopausal women with and without genitourinary syndrome with the Mann-Whitney test. To assess the correlation between estradiol and CRP levels, and between their levels with the presence of genitourinary symptoms, the Spearman correlation test was used. The genitourinary syndrome was reported in 25% of the total included menopausal women. Our data indicated that the mean estradiol levels were not significantly different between menopausal women with and without genitourinary syndrome (9.13±2.47 pg/mL vs 18.96±31.23 pg/mL, p=0.881). The mean serum CRP level of menopausal women with genitourinary syndrome (9.72±6.30 mg/L) was higher than that of women without the syndrome (2.09±1.26 mg/L) with p<0.001. In addition, serum CRP level, not estradiol, was correlated with the symptom score of genitourinary syndrome. This study highlights that to identify and manage genitourinary syndrome, monitoring of CRP levels is essential in menopausal women.
Role of serum estradiol and C-telopeptide on musculoskeletal pain in menopausal women Siregar, Muhammad FG.; Terauchi, Masakazu; Lumbantobing, Jonathan T.; Pasaribu, Hotma P.; Prabudi, Muhammad O.; Ardiansyah, Edy; Effendi, Iman H.; Tobing, Immanuel DL.; Azmeila, Selly; Nabila, Nabila
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.747

Abstract

Musculoskeletal pain is one of the common symptoms of menopause syndrome throughout the world. Estradiol is the most potent and abundant derivative of estrogen and is associated with musculoskeletal pain, stiffness, and depressed mood during the menopausal transition. C-telopeptide is a molecule released during osteoclastic bone resorption and degradation of type I collagen, which is reported to have higher levels in individuals with musculoskeletal pain. An observational analytical study with a cross-sectional design was used in this research. Estradiol and C-telopeptide levels were measured in this study using enzyme-linked immunosorbent assay (ELISA). Musculoskeletal pain was assessed using the Nordic Musculoskeletal Questionnaire (NMQ) and the Menopause Quality of Life Questionnaire (MENQOL). Musculoskeletal pain was determined if the participant answered “yes” on questions number 12, 14 and 25 on the MENQOL. Data analysis was performed using the independent Student t-test for normally distributed data and the Mann-Whitney test for non-normally distributed data. A correlation test was performed using the Pearson correlation test for normally distributed data and the Spearman correlation test for non-normally distributed data. The results showed a non-significant relationship between estradiol and C-telopeptide levels with musculoskeletal pain assessed using the NMQ or MENQOL questionnaires. The correlation test also showed no correlation between estradiol and C-telopeptide levels in women with and without musculoskeletal pain.
Co-Authors Azmeila, Selly Benjamin Sihite Chandran Frinaldo Saragih Djaganata, Servin Pandu Dwi Putri, Savira Effendi, Iman H. Fadjrir Fadjrir Iman Helmi Effendi Iman Helmi Effendi Kaban, Yostoto B Khairani Sukatendel Lubis, Roni B. Lumbantobing, Jonathan T. Makmur Sitepu, Makmur Mohamad Fauzie Sahil Muhammad Rizki Yaznil Nabila, Nabila Nasution, Muhammad Siddik Paramita, Deryne Anggia Pasaribu, Hotma P. Prabudi, Muhammad O. Prabudi, Oky Ramadani, Sumi Riza Rivany Rizki Yaznil Sarirah, Munauwarus Sarma Nursani Lumbanraja Sihite, Herbert Siregar, Hendry Salim Siregar, Henry Salim Siregar, Muhammad FG. Syafardi, D. Irsat Tala, M. Rhiza Z Terauchi, Masakazu Tobing, Immanuel DL. Yulfi, Hemma