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All Journal Narra J
Rozi, Muhammad F.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Prevalence and distribution of intestinal parasitic infections in taeniasis endemic area of North Sumatera, Indonesia Yulfi, Hemma; Darlan, Dewi M.; Panggabean, Merina; Andriyani, Yunilda; Rozi, Muhammad F.; Wandra, Toni
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.912

Abstract

A group of helminthic and intestinal protozoa causes intestinal parasitic infections (IPIs), affecting more than 2.5 billion people worldwide. IPIs are diseases closely associated with poor hygiene and sanitation, concentrated in underdeveloped regions and among populations with low socioeconomic status. Consequently, most prevalence is in Sub-Saharan Africa and Asia, with local habits or risk factors that could affect its prevalence. The aim of this study was to determine how hygienic practices, sanitation, and local behavior of eating raw meat (hinasumba) contributed to the prevalence of IPI. A cross-sectional study was conducted in the Simalungun District of North Sumatera Province, involving 428 people of Batak Simalungun. There were 15 villages randomly selected across the district based on the local registry, which consequently, non-purposive sampling was conducted. Face-to-face interviews assessed various risk factors, such as demographic characteristics, water source, traditional raw meat consumption, or hinasumba as local risk factors, hygienic practices, and sanitation. The findings indicated that an overall prevalence rate of IPI was 42.9%, consisting of 87.5% with helminthic infection and 12.5% with protozoal infection. More than half of IPI cases were associated with Taenia sp. infections (21.8%), followed by hookworms’ infections with a 6.1% positivity rate. Based on multivariate analysis, farming and consuming traditional delicacies, namely hinasumba, increased the likelihood of IPI occurrence among the population by 1.7 and 3 times, respectively. It can be concluded that the high prevalence of taeniasis in the study area was associated with local behavior and hinasumba consumption, which may contribute to determining the dominance of specific IPI species.
Mesenchymal stem cells for immune modulation in systemic lupus erythematosus: From bench research to clinical applications Ginting, Andi R.; Munir, Delfitri; Amin, Mustafa M.; Darlan, Dewi M.; Putra, Agung; Rusda, Muhammad; Mutiara, Erna; Mayasari, Evita; Rozi, Muhammad F.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.994

Abstract

Systemic lupus erythematosus (SLE) is a prevalent autoimmune disease affecting multiple organ systems. Disease progression is inevitable as part of its natural course, necessitating aggressive therapeutic strategies, particularly with the use of immunosuppressants. Long-term use of steroids and other immunosuppressants is associated with significant adverse effects. Mesenchymal stem cells (MSCs) have been shown to modulate the immune response, leading to immunosuppressive effects against self-antigens. MSCs have demonstrated the ability to modulate several immune cell populations, contributing to favorable outcomes in controlling immune and inflammatory conditions. Recent evidence has shown an increase in Treg and Breg cell subsets following MSC administration, along with modulation of other immune cells, including dendritic cells, B cells, and T cells. However, the balance between MSC pro-inflammatory and anti-inflammatory phenotypic activation remains a critical factor in determining therapeutic outcomes. Various covariates also influence the efficacy of MSC therapy. The aim of this study was to provide a comprehensive overview of the utilization of mesenchymal stem cells (MSCs) in SLE treatment, leveraging their immunomodulatory and immunosuppressive capabilities. Understanding the fundamental preclinical effects of MSCs and recent findings from clinical studies may enhance the potential of MSC therapy in the management of SLE patients.
Community-based intervention in mosquito control strategy: A systematic review Yulfi, Hemma; Panggabean, Merina; Darlan, Dewi M.; Siregar, Irma SS.; Rozi, Muhammad F.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1015

Abstract

As part of the World Health Organization’s One Health Initiative, vector-borne disease control requires multidisciplinary and community involvement. This review examined community-based mosquito control intervention methods, their efficacy, and limitations. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, data were extracted from four medical databases: PubMed, Clinical Key, ProQuest, and ScienceDirect, covering the period from 2014 to 2023. The search used the keywords "community intervention," "vector control," and "mosquito." Filters were applied for full text, primary sources, scholarly journals, and publications within the last ten years (2014–2023). Studies without community intervention components were excluded. The initial search retrieved 1,035 articles, and 32 full-text articles were selected and assessed for eligibility, with 15 papers included in the final analysis. The included studies focused on arbovirus or malaria vectors and used randomized controlled trials (RCTs), pre- and post-intervention surveys, community-based implementation surveys, or qualitative research designs. Commonly applied interventions included community-driven vector population control and community education. Overall, the studies reported improvements in outcome measures such as entomological indices, community knowledge and practices, costs, and disease incidence or prevalence. However, some studies reported challenges with community perception and acceptance. In conclusion, this review consistently demonstrated a positive impact of community interventions on managing mosquito control.
Co-Authors Agung Putra Amin, Mustafa M. Andriyani, Yunilda Darlan, Dewi M. Delfitri Munir Erna Mutiara Evita Mayasari Ginting, Andi R. Merina Panggabean Rusda, Muhammad Siregar, Irma SS. Toni Wandra Yulfi, Hemma