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All Journal Indonesian Journal of Biotechnology Majalah Farmaseutik Jurnal Studi Islam Lintas Negara (Journal of Cross-Border Islamic Studies)
Khafi, Muhammad
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Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Analyzing the Potential of Herbal Plant Research for Alzheimer's Disease in Diabetes: A Bibliometric Approach Marzuki, Ahmad; Rahmayani, Almira; Khafi, Muhammad; Hertiani, Triana; Murwanti, Retno
Majalah Farmaseutik Vol 20, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i3.97209

Abstract

Alzheimer’s disease is a progressive neurologic dementia disorder and the fifth leading cause of death among elderly individuals. Its pathogenesis is closely linked to diabetes-induced brain insulin resistance, which accelerates beta-amyloid accumulation, exacerbating disease severity. This condition significantly impacts quality of life and healthcare costs, necessitating effective treatment strategies. Medicinal plants offer a promising avenue, with bibliometric analysis identifying trending active compounds for potential development as therapies for diabetic Alzheimer’s. This study analyzed 200 articles from the Scopus database, employing Scopus and VOSviewer 1.6.20 to visualize bibliometric trends by publication, country/territory, subject area, and keyword co-occurrence. Results indicate a recent decline in research activity, with China leading in publications across pharmacology, medicine, and biochemistry. Notably, flavonoids like “quercetin,” “kaempferol,” and “gallic acid” emerged as prominent topics.Keywords: Alzheimer’s diabetes, Bibliometrics, Herbal medicine, Extracts
Formulation and Stability Test of HPMC and Carbomer 940 based-Gel Formulation Containing Plantago major L. hydroalcoholic extract Khafi, Muhammad; Hertiani, Triana; Murwanti, Retno; Bayu Irawan, Muhamad; Marzuki, Ahmad; Dwi Salim, Rozin
Majalah Farmaseutik Vol 21, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.95893

Abstract

The P. major plant has long been utilized in traditional herbal medicine and is widely accessible in Indonesia and globally. Extensive research has demonstrated its efficacy in wound healing through both clinical and preclinical studies. Gel formulations are recognized for establishing a conducive moist environment essential for wound healing, thus rendering them suitable for topical wound treatment. This study assesses the stability of HPMC gel base, carbomer 940, and their combination as carriers for the ethanol extract of P. major leaves. Stability testing involved a freeze-thaw cycle test at temperatures of 4°C and 40°C for three cycles. The findings indicate no significant alteration in the organoleptic properties and pH of the gel formulations before and after stability testing. However, t-test analysis reveals a noteworthy decrease in viscosity for carbomer and its combination, albeit not for HPMC alone. In conclusion, HPMC exhibits superior stability as a gel base compared to Carbomer 940 and their combination.
Dinamika Sosial dalam Implementasi Kurikulum Pendidikan Agama Islam di Sekolah Umum VS Sekolah Islam: Balancing Tradition and Innovation: The Dynamics of Islamic Values in the Curriculum at Pondok Gontor 4 Choirur Rizki, Refa; Farah Azizah, Ismi; Nurfaizah; Nur Hikmah, Elsha; Khafi, Muhammad
CBJIS: Cross-Border Journal of Islamic Studies Vol. 7 No. 1 (2025): Juni
Publisher : Fakultas Tarbiyah dan Ilmu Keguruan, IAI Sultan Muhammad Syafiuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37567/cbjis.v7i1.3989

Abstract

Penelitian yang membahas mengenai dinamika penerapan nilai-nilai Islam dalam kurikulum Pondok Pesantren Gontor 4, dengan fokus pada upaya penyeimbangan nilai-nilai Islam dengan inovasi pendidikan modern. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan pengumpulan data melalui wawancara mendalam, observasi, serta studi dokumentasi. Hasil penelitian menunjukkan bahwa Gontor 4 berhasil dalam mengintegrasikan nilai-nilai islam klasik seperti keikhlasan, kesederhanaan, dan kemandirian ke dalam sistem pendidikan secara keseluruhan dan berkelanjutan. Inovasi diimplementasikan melalui metode pembelajaran aktif, pemanfaatan teknologi yang selektif, serta pengembangan dalam bentuk ekstrakurikuler yang mendukung pembentukkan karakter dan keterampilan santri yang berguna dalam kehidupan sehari-hari. Kurikulum Gontor yang diterapkan serta system manajemen pendidikan yang terstruktur memperkuat internalisasi nilai-nilai islam serta tradisi turun temurun. Penelitian ini jiga menegaskan bahwa tradisi dan inovasi bukanlah hal yang bertentangan, melainkan dapat menjadi integrase positif dalam menciptakan pendidikan islam yang relevan, adaptif, dan inovatif serta berdaya saing global
Decoding the role of tannic acid in wound healing: a dual‐action mechanism linking IL‐1β modulation and FGF‐driven tissue repair Swastini, Dewa Ayu; Nugroho, Agung Endro; Martien, Ronny; Fachiroh, Jajah; Khafi, Muhammad; Putra, Komang Dian Aditya
Indonesian Journal of Biotechnology Vol 31, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.113925

Abstract

Tannic acid (TA) has been shown in a previous study to expedite cutaneous wound healing in rats; however, the precise mechanism by which it operates remains poorly understood. This research evaluates the effects of TA on wound healing using both in vitro and in silico methods. In vitro, its influence on the inflammatory cytokine interleukin‐1β (IL‐1β) and the growth factor fibroblast growth factor (FGF) throughout the healing process were assessed. In silico molecular docking was employed to predict direct ligand–protein interactions and to provide a mechanistic insight into whether these proteins represent primary molecular targets or downstream effects. Parameters evaluated included cell viability and proliferation, scratch assays, and the activity of pro‐inflammatory cytokines in the lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophage cell line, together with growth factors in the NIH 3T3 fibroblast cell line; all were evaluated using enzyme‐linked immunosorbent assay (ELISA). The results indicate that TA significantly facilitates wound closure by promoting NIH 3T3 fibroblast cell proliferation, enhancing FGF expression, and suppressing IL‐1ß synthesis in both in vitro and in silico approaches. These findings suggest that TA may hold considerable promise for wound‐healing management.
Co-Authors Agung Endro Nugroho Ahmad Marzuki Bayu Irawan, Muhamad Choirur Rizki, Refa Dewa Ayu Swastini Dwi Salim, Rozin Farah Azizah, Ismi Jajah Fachiroh, Jajah Nur Hikmah, Elsha Nurfaizah Putra, Komang Dian Aditya Rahmayani, Almira Retno Murwanti Ronny Martien Triana Hertiani