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All Journal Scientific Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Fasril, Thira
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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V-Y FLAP pada Squamous Cell Carcinoma Mandibula: Laporan Kasus Fortuna, Fory; Fasril, Thira
Scientific Journal Vol. 2 No. 4 (2023): SCIENA Volume II No 4, July 2023
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v2i4.122

Abstract

Karsinoma sel skuamosa (SCC) merupakan kanker kulit non-melanoma. Karsinoma sel skuamosa adalah karsinoma keratinosit yang menjadi penyebab sebagian besar penyakit metastasis dan kematian akibat kanker kulit nonmelanoma. Histopatologi dan eksisi bedah yang benar tetap menjadi standar emas untuk diagnosis dan pengobatan SCC. Karsinoma sel skuamosa diklasifikan  menjadi  SCC in situ dan bentuk invasif. Peningkatan resiko SCC adalah usia lanjut, eksposur matahari, imunosupresi, dan riwayat kanker kulit sebelumnya. Histopatologi merupakan pemeriksaan untuk dasar tegaknya diagnosis SCC. Tulisan ini melaporkan seorang perempuan berusia 64 tahun dengan keluhan benjolan disekitar mulut dan rahang bawah. Benjolan dirasakan semakin membesar dalam tiga bulan terakhir. Pasien memiliki riwayat penurunan berat badan 10 kg dan merupakan seorang petani. Saat, dilakukan pemeriksaan fisik, pada regio mentalis ditemukan benjolan berukuran 6x4x3 cm. Pada pemeriksaan biopsi   diagnosis   pasien   adalah   keratinized   squamous   cell   carcinoma   moderate   to    poorly differentiated. Pada pasien dilakukan mandibulektomi dan dilanjutkan rekontruksi V-Y flap. Tahap pertama adalah membuat sayatan berbentuk huruf V. Tahap kedua bertujuan untuk membentuk bagian mandibular dengan menggeser membentuk huruf Y.
Profile of carbapenemase genes among sepsis patients at a tertiary hospital in Indonesia Fadrian, Fadrian; Linosefa, Linosefa; Ahmad, Armen; Ulvyana, Vyora; Putri, Vidola Yasena; Fasril, Thira
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art9

Abstract

Background: Multidrug-resistant gram-negative bacteria represent a major clinical challenge in patients with sepsis. Recent data indicate that the increasing global prevalence of carbapenemase-producing bacteria poses an urgent threat to public health. Objectives: This study aimed to describe the distribution of carbapenemase genes among sepsis patients at Dr. M. Djamil General Hospital, Padang. Methods: This was a descriptive cross-sectional study involving 211 specimens obtained from sepsis patients over a nine-month period of hospitalization at Dr. M. Djamil General Hospital. Specimens consisted of blood, respiratory, pus, and urine specimens. Detection of carbapenemase genes including blaKPC, blaOXA, blaNDM, blaVIM, blaIMP, and blaGES was performed using real-time PCR. Data were analyzed descriptively and the Chi-square test was used with IBM SPSS Statistics version 25.0. Results: Among the sepsis patients included in the study, 211 specimens were analyzed; most patients were aged over 60 years (53.1%) and were predominantly male (57.3%). The most frequent sources of infection were CAP (52.1%) and HAP (33.2%). Positive bacterial cultures were found in 58.8% of patients, with Klebsiella pneumoniae (39.8%) and Escherichia coli (7.6%) being the most prevalent isolates. The distribution of carbapenemase genes was dominated by the blaOXA gene (33.6%) and the blaNDM gene (22.3%), while blaGES (4.7%), blaVIM (4.3%), and blaIMP (0.9%) were identified in only a limited number of isolates. The mean SOFA score was 5.75 ± 3.16, and the overall mortality rate was 66.4%. The results of statistical analysis showed that there was no significant relationship between the presence of the carbapenemase gene and mortality (OR 0.683; 95% CI=0.384–1.216; p=0.195). Isolates carrying carbapenemase genes were significantly associated with carbapenem resistance (OR=11.15; 95% CI: 5.28–23.55; p<0.05).Conclusion: In this study, blaOXA and blaNDM were the predominant genes, while blaVIM, blaGES, and blaIMP were detected in a limited number of isolates.
Co-Authors Ahmad, Armen Fadrian, Fadrian Fortuna, Fory Linosefa Linosefa Putri, Vidola Yasena Ulvyana, Vyora