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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal RSMH Palembang
Muhammad Novran Chalik
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Resistance Patterns in Drug-Resistant Pulmonary Tuberculosis Patients at Dr. Mohammad Hoesin Palembang Hospital Muhammad Novran Chalik; Alif Fathurrachman; Linda Andriani; Rouly Pasaribu; Sudarto; Ahmad, Zen; Ahmad Rasyid
Jurnal RSMH Palembang Vol. 5 No. 1 (2024): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v5i1.64

Abstract

Tuberculosis (TB) is a contagious infectious disease caused by acid-resistant bacteria, Mycobacterium Tuberculosis (MTb). Based on immunity, there are two types of pulmonary TB infection: drug-sensitive and drug-resistant. Based on ATD sensitization tests, MTb resistance types consist of TB that is monoresistant, polyresistant, multidrug resistance (MDR), pre-extensively drug resistant (Pre-XDR), extensively drug-resistant (XDR). Globally, in 2022, there will be an estimated 450,000 cases of DR-TB, but only 161,000 treated. In Indonesia, in 2022, there were an estimated 24,000 cases of DR-TB; only 8,268 were notified and 5,082 cases had started therapy. In this study, conducted with a retrospective descriptive method, during the period 2022 at RSMH Palembang, 92 patients with DR-TB were obtained who received treatment at RSMH Palembang. Of the 92 subjects, the mean age of diagnosis of DR-TB was 44.47 ± 16.5. The most common gender was male 62 subjects (67.4%) and 30 subjects were female (32.6%). Of the 92 rifampicin-resistant patients, there were a total of 39 patients (42.4%) with isoniazid resistance. Among these 39 patients, 21 patients (54%) were primary resistance cases and 18 patients (46%) were secondary resistance cases. The most common type of therapy regimen used was a long-term regimen as many as 68 subjects (74%) and short-term as many as 24 subjects (26%)Primary resistance patterns were obtained in 43 subjects (46.8%) and secondary resistance in 49 subjects (53.2%). Of the 49 secondary resistance subjects, 52 subjects (56.5%) had TB-RR, 33 subjects (35.8%) had MDR-TB, 6 subjects (6.5%) had pre-XDR TB, and 1 subject (1.2%) had XDR-TB. The researcher concluded that the dominant resistance pattern of pulmonary TB cases was secondary resistance, with the results of the drug sensitivity test being TB-RR. However, it should be noted that DR-TB with a primary resistance pattern also has a higher percentage.
CORRELATION OF APOLIPOPROTEIN B LEVELS WITH THE DEGREE OF CORONARY ARTERY STENOSIS IN CHRONIC CORONARY SYNDROME PATIENTS Muhammad Novran Chalik; Erwin Sukandi; Irfannuddin; Syamsu Indra; Zen Ahmad
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 1 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/nje73q38

Abstract

Apolipoproteins are structural components of plasma lipoproteins that involved in lipoprotein metabolism and lipid transport, reflect the number of circulating atherogenic particles. This study aims to investigate the correlation between serum apolipoprotein B levels and the degree of coronary artery stenosis in patients with chronic coronary syndrome. A cross-sectional study design was used, involving 34 patients selected from a total population of 69 individuals. Data were collected from July 2024 to September 2024. The results showed that most respondents had elevated apolipoprotein B levels, with a mean value of 141.41 ± 25.06 mg/dL, and SYNTAX score of ≥ 23, with a mean value of 24.09 ± 2.69. Pearson’s correlation test indicated a significant relationship between apolipoprotein B levels and SYNTAX scores (p = 0.029, r = 0.376). Multivariate analysis revealed a significant p-value for apolipoprotein B (p = 0.017) with a positive regression coefficient.
Co-Authors Ahmad Rasyid Ahmad, Zen Alif Fathurrachman Erwin Sukandi Irfannuddin Irfannuddin Linda Andriani Rouly Pasaribu Sudarto Syamsu Indra Zen Ahmad