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All Journal Padjadjaran Journal of Dentistry Medical and Health Journal
Rosyada, Alya Ghina
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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POTENTIAL OF RED ONION PEEL ETHANOL EXTRACT (Allium cepa L.) TO DEGRADATION OF Staphylococcus aureus BIOFILM Sari, Dwi Nur Indah; Rosyada, Alya Ghina; Laksitasari, Anindita; Djati, Fanni Kusuma; Andini, Restian Febi
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11371

Abstract

Dental biofilm is a bacterial colonization adhering to the tooth surface, enveloped by an extracellular matrix. This biofilm shields bacteria from the body's defense and antibacterial systems, potentially leading to various dental and oral diseases.Staphylococcus aureus is among the bacteria forming dental biofilm. Red onion peel is known to contain flavonoids, saponins, tannins, steroids and alkaloids which have antibacterial and anti-biofilm activity. This study aimed to determine the potential of shallot peel extract in degrading S. aureus biofilms. This study was conducted with a posttest-only control group design. Red onion peel extraction is carried out using the maceration method. A total of 5 groups of extracts (50%, 25%, 12.5%, 6.25%, and 3.12%), positive control (chlorhexidine gluconate 0.2%), and negative control (DMSO 1%) were tested for their activity in S. aureus biofilm degradation at 24 and 48 hours of incubation. The biofilm degradation was assessed using the microtiter plate assay method with crystal violet staining read at a wavelength of 595 nm. Percent biofilm degradation was statistically analyzed using Two way ANOVA and LSD. The results indicated significant differences based on treatment, incubation time, and the interaction between the two. The highest activity was observed at a concentration of 25%, although it was still lower than that of positive control. Conclusion: the ethanol extract of red onion peel has the potential to degrade S. aureus biofilms, with the highest activity at a concentration of 25% and an incubation time of 48 hours.
Aloe vera extract wound healing sheet and free-range chicken egg albumin (gallus domesticus) accelerate angiogenesis on gingival incision wound in rats Putri, Myrna Evana Amanda; Prihastuti, Christiana Cahyani; Rochmawati, Mutia; Rosyada, Alya Ghina; A'ziza, Wizni A'dila
Padjadjaran Journal of Dentistry Vol 35, No 1 (2023): March 2023
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol35no1.42775

Abstract

ABSTRACTIntroduction: Incision wounds are injuries caused by dental surgery procedures. Suturing is the gold standard for post-incision management, but it can cause patient discomfort. Tissue glue can be used for wound healing, but its carcinogenicity still needs to be investigated. A Wound Healing Sheet (WHS) made of Aloe vera extract and free-range chicken egg albumin is expected to be an alternative material. Angiogenesis is a highly observable part of wound healing, as newly formed blood vessels support nutrition, act as a scaffold for cells to migrate to the wound area, and play an essential role in wound healing. This study aimed to analyze the effect of WHS made from Aloe vera extract and free-range chicken egg albumin (Gallus domesticus) on the number of vascular that show the acceleration of healing in gingival incision wounds. Methods: Quasi experimental study with a total sample of 24 male rats (Rattus norvegicus Wistar strain) with gingival incision were divided into four groups, namely T1 (50% WHS treated group), T2 (100% WHS treated group, S (suturing treated group as positive control), and NC (negative control, without treatment). The treatment was performed throughout seven days. The data obtained were analyzed statistically using One-way ANOVA and Post Hoc LSD. Results: The highest vascular count was in the T2 Group (8+1.63); followed by T1 (7+1.60); S (7+ 1.49); and NC (4+1.41). Statistical analysis showed that there was a significant difference between groups S, T1, T2 with NC (p-value < 0.05); interestingly, there was no significant difference between S, T1, T2 (p-value > 0.05). Conclusion: Wound Healing Sheet made of Aloe vera extract and free-range chicken egg albumin (Gallus domesticus) can accelerate the angiogenesis process on gingival incision wound in rats.Keywords: wound healing, aloe vera, gallus domesticus, egg white, angiogenesis
Co-Authors A'ziza, Wizni A'dila Andini, Restian Febi Dwi Nur Indah Sari Fanni Kusuma Djati Laksitasari, Anindita Mutia Rochmawati, Mutia Prihastuti, Christiana Cahyani Putri, Myrna Evana Amanda