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All Journal Jurnal Kedokteran Brawijaya Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Medical and Health Journal
Rosyada, Alya Ghina
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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POTENTIAL OF RED ONION PEEL ETHANOL EXTRACT (Allium cepa L.) TO DEGRADATION OF Staphylococcus aureus BIOFILM Sari, Dwi Nur Indah; Rosyada, Alya Ghina; Laksitasari, Anindita; Djati, Fanni Kusuma; Andini, Restian Febi
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11371

Abstract

Dental biofilm is a bacterial colonization adhering to the tooth surface, enveloped by an extracellular matrix. This biofilm shields bacteria from the body's defense and antibacterial systems, potentially leading to various dental and oral diseases.Staphylococcus aureus is among the bacteria forming dental biofilm. Red onion peel is known to contain flavonoids, saponins, tannins, steroids and alkaloids which have antibacterial and anti-biofilm activity. This study aimed to determine the potential of shallot peel extract in degrading S. aureus biofilms. This study was conducted with a posttest-only control group design. Red onion peel extraction is carried out using the maceration method. A total of 5 groups of extracts (50%, 25%, 12.5%, 6.25%, and 3.12%), positive control (chlorhexidine gluconate 0.2%), and negative control (DMSO 1%) were tested for their activity in S. aureus biofilm degradation at 24 and 48 hours of incubation. The biofilm degradation was assessed using the microtiter plate assay method with crystal violet staining read at a wavelength of 595 nm. Percent biofilm degradation was statistically analyzed using Two way ANOVA and LSD. The results indicated significant differences based on treatment, incubation time, and the interaction between the two. The highest activity was observed at a concentration of 25%, although it was still lower than that of positive control. Conclusion: the ethanol extract of red onion peel has the potential to degrade S. aureus biofilms, with the highest activity at a concentration of 25% and an incubation time of 48 hours.
Aloe vera extract wound healing sheet and free-range chicken egg albumin (gallus domesticus) accelerate angiogenesis on gingival incision wound in rats Putri, Myrna Evana Amanda; Prihastuti, Christiana Cahyani; Rochmawati, Mutia; Rosyada, Alya Ghina; A'ziza, Wizni A'dila
Padjadjaran Journal of Dentistry Vol 35, No 1 (2023): March 2023
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol35no1.42775

Abstract

ABSTRACTIntroduction: Incision wounds are injuries caused by dental surgery procedures. Suturing is the gold standard for post-incision management, but it can cause patient discomfort. Tissue glue can be used for wound healing, but its carcinogenicity still needs to be investigated. A Wound Healing Sheet (WHS) made of Aloe vera extract and free-range chicken egg albumin is expected to be an alternative material. Angiogenesis is a highly observable part of wound healing, as newly formed blood vessels support nutrition, act as a scaffold for cells to migrate to the wound area, and play an essential role in wound healing. This study aimed to analyze the effect of WHS made from Aloe vera extract and free-range chicken egg albumin (Gallus domesticus) on the number of vascular that show the acceleration of healing in gingival incision wounds. Methods: Quasi experimental study with a total sample of 24 male rats (Rattus norvegicus Wistar strain) with gingival incision were divided into four groups, namely T1 (50% WHS treated group), T2 (100% WHS treated group, S (suturing treated group as positive control), and NC (negative control, without treatment). The treatment was performed throughout seven days. The data obtained were analyzed statistically using One-way ANOVA and Post Hoc LSD. Results: The highest vascular count was in the T2 Group (8+1.63); followed by T1 (7+1.60); S (7+ 1.49); and NC (4+1.41). Statistical analysis showed that there was a significant difference between groups S, T1, T2 with NC (p-value < 0.05); interestingly, there was no significant difference between S, T1, T2 (p-value > 0.05). Conclusion: Wound Healing Sheet made of Aloe vera extract and free-range chicken egg albumin (Gallus domesticus) can accelerate the angiogenesis process on gingival incision wound in rats.Keywords: wound healing, aloe vera, gallus domesticus, egg white, angiogenesis
Efektivitas wound healing sheet ekstrak Aloe vera dan albumin telur ayam kampung (Gallus domesticus) terhadap penyembuhan luka insisi gingivaWound healing sheet with Aloe vera extract and free-range chicken egg albumin (Gallus domesticus) for healing of gingival incisions Rosyada, Alya Ghina; A'ziza, Wizni A'dila; Putri, Myrna Evana Amanda; Rochmawati, Mutia
Padjadjaran Journal of Dental Researchers and Students Vol 6, No 2 (2022): Juni 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v6i2.39927

Abstract

ABSTRAKPendahuluan: Insisi merupakan hal yang sering dilakukan pada praktik kedokteran gigi. Penanganan standar untuk luka insisi adalah suturing. Suturing dapat menyatukan jaringan yang terluka dengan baik namun dapat menimbulkan ketidaknyamanan pada beberapa pasien. Salah satu metode alternatif suturing adalah lem jaringan. Bahan yang umum digunakan untuk lem jaringan adalah 2 octyl-cyanoacrylate. Penggunaan bahan ini cukup nyaman tetapi berisiko menimbulkan inflamasi seperti pada suturing. Lem jaringan wound healing sheet (WHS) yang berbahan dasar ekstrak Aloe vera dan albumin telur ayam kampung diharapkan mampu menjadi metode alternatif untuk penyembuhan luka insisi pada gingiva. Penelitian ini bertujuan untuk mengetahui efektivitas WHS dalam menyembuhkan luka insisi gingiva. Metode: Sebanyak 24 ekor tikus jantan (Rattus norvegicus galur Wistar) dengan gingiva yang telah diinsisi dibagi menjadi empat kelompok, yaitu K1 (kontrol negatif tanpa perlakuan), K2 (kontrol positif perlakuan suturing), K3 (WHS konsentrasi 50%), dan K4 (WHS konsentrasi 100%). Perlakuan dilakukan selama tujuh hari. Data yang diperoleh dianalisis menggunakan One Way ANOVA dan dilanjutkan dengan Post Hoc LSD. Hasil: Nilai persentase penyembuhan luka dari yang tertinggi ke yang terendah berturut-turut adalah K4, K3, K1, dan K2. Nilai jumlah fibroblas dari yang tertinggi ke yang terendah berturut-turut adalah K4, K3, K2, dan K1. Hasil p-value (p < 0,05) menunjukkan terdapat perbedaan yang signifikan antarkelompok sampel pada kedua data tersebut. Simpulan: Wound healing sheet ekstrak daun Aloe vera dan albumin telur ayam kampung efektif untuk penyembuhan luka insisi gingiva.Kata kunci: Wound healing; Aloe vera; lem jaringan; albumin; putih telur ABSTRACTIntroduction: Incision is a common practice in dentistry. The standard treatment for incisional wounds is suturing. Suturing can hold injured tissue well but may be uncomfortable for some patients. One alternative method of suturing is tissue glue. A common material used for tissue glue is 2 octyl-cyanoacrylate. The use of this material is quite comfortable but has the risk of causing inflammation as in suturing. Wound healing sheet (WHS) tissue glue based on Aloe vera extract and chicken egg albumin is expected to be an alternative method for healing gingival incisions. This study aims to determine the effectiveness of WHS in healing gingival incision wounds. Methods: A total of 24 male rats (Rattus norvegicus Wistar strain) with incised gingiva were divided into 4 groups, K1 (negative control without treatment), K2 (positive control with suturing treatment), K3 (WHS concentration of 50%), and K4 (WHS concentration of 100%). The treatment was carried out for 7 days. The data were analyzed using One Way ANOVA and followed by Post Hoc LSD. Results: The percentage values of wound healing from the highest to the lowest were K4, K3, K1, and K2. The values for the number of fibroblasts from the highest to the lowest were K4, K3, K2, and K1. The results of the p-value (p < 0.05) showed that there was a significant difference between the sample groups in the two data. Conclusion: Wound healing sheet made from Aloe vera leaf extract and chicken egg albumin is effective for healing gingival incision wounds.Keywords: Wound healing; Aloe vera; tissue adhesive; albumin; white egg
Aloe vera Extract Sheet and Egg Albumin (Gallus domesticus) Reduce the Number of Lymphocytes on Gingival Incision Wound A'ziza, Wizni A'dila; Prihastuti, Christiana Cahyani; Rochmawati, Mutia; Rosyada, Alya Ghina; Amanda Putri, Myrna Evana
Jurnal Kedokteran Brawijaya Vol. 32 No. 4 (2023)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.032.04.2

Abstract

An incision in the oral cavity is a dental procedure performed in surgical procedures. Suturing is the gold standard in primary wound closure care, however, suturing can cause tissue trauma, scars, and secondary infections. Cyanoacrylate adhesive is one of the alternative tissue glue for wound closure but it has inflammatory risk as suturing, potential toxicity, and accidental adhesion risks. Aloe vera extract sheet based combined with free-range chicken egg albumin is expected to be an alternative method for wound healing of gingival incisions. This study aimed to investigate the effect of administration of Aloe vera extract wound healing sheet (WHS) and free-range chicken egg albumin on the number of lymphocytes in the gingival incision wound as the inflammatory response. Experimental laboratory research with a posttest-only control group design was conducted in 24 male rats (Rattus norvegicus Wistar strain) with an incised gingiva, divided into four groups, namely T1 (50% WHS concentration and chicken egg albumin), T2 (100% WHS concentration and chicken egg albumin), PC (positive control with suturing), NC (negative control without treatment). The treatment was carried out for seven days. The data obtained were analyzed statistically using One-way ANOVA and Post Hoc LSD. The use of Aloe vera extract WHS and free-range chicken egg albumin (T1 and T2) reduced the number of lymphocytes compared to control groups (PC and NC; p<0.05). WHS and chicken egg albumin can shorten the inflammatory process in wound healing which is characterized by lower lymphocyte counts compared to the control groups.
Co-Authors A'ziza, Wizni A'dila Amanda Putri, Myrna Evana Andini, Restian Febi Dwi Nur Indah Sari Fanni Kusuma Djati Laksitasari, Anindita Mutia Rochmawati Prihastuti, Christiana Cahyani Putri, Myrna Evana Amanda