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All Journal Medali Jurnal : Media Dental Intelektual STOMATOGNATIC- Jurnal Kedokteran Gigi MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Jurnal Kedokteran Gigi Universitas Padjadjaran MDJ (Makassar Dental Journal) Makara Journal of Science Mandala of Health : A Scientific Journal Medical and Health Journal Biomedika
Fanni Kusuma Djati
Universitas Jenderal Soedirman
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Stomatitis venenata terkait alergi bahan sementasi zink fosfat yang jarang ditemukanStomatitis venenata: A rare zinc phosphate cementation related allergy Fanni Kusuma Djati; Affan Wirutomo; Christiana Cahyani Prihastuti
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 2 (2019): Agustus 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.03 KB) | DOI: 10.24198/jkg.v31i2.21483

Abstract

Pendahuluan: Salah satu reaksi hipersensitivitas tipe IV yang dapat terjadi pada rongga mulut adalah Stomatitis venenata atau disebut juga stomatitis kontak alergi. Stomatitis venenata jarang sekali terjadi dan jarang sekali disadari oleh para dokter gigi. Stomatitis venenata dapat timbul karena reaksi alergi namun seringkali dihiraukan dan menyebabkan kesalahan mendiagnosis. Akibat dari kesalahan mendiagnosis akan menyebabkan kesalahan perawatan pada pasien. Tujuan dari laporan kasus ini adalah memaparkan kasus Stomatitis venenata yang terkait alergi zink fosfat beserta penatalaksanaannya, di Rumah Sakit Gigi dan Mulut Universitas Jenderal Soedirman. Laporan kasus: Seorang laki-laki usia 25 tahun datang mengeluhkan adanya sariawan di pipi kiri bagian dalam dekat gusi yang terasa sakit sejak 5 hari yang lalu disertai keropeng pada pipi kiri. Hasil pemeriksaan ekstraoral pada bagian pipi kiri terdapat lesi berupa krusta multiple yang telah mengering, sedangkan hasil pemeriksaan intra oral mendapatkan lesi berwarna kemerahan pada mukosa bukal kiri. Lesi tersebut dicurigai muncul akibat bahan sementasi zink fosfat yang menyentuh mukosa bukal. Diagnosis klinis yang ditegakkan adalah Stomatitis venenata yang disebabkan alergi terhadap paparan zink fosfat pada daerah sekitar lesi. Penatalaksanaan yang dilakukan adalah menghilangkan zat alergen yang dicurigai menyebabkan reaksi alergi dan pemberian obat kortikosteroid topikal untuk mengurangi rasa nyeri. Lesi Stomatitis venenata berangsur sembuh setelah dilakukan penatalaksanaan. Simpulan: Stomatitis venenata dengan menghilangkan zat alergen kemudian menggantikan dengan bahan lain menunjukkan adanya perbaikan pada keadaan mukosa oral pasien, selain itu pemberian obat kortikosteroid topikal meningkatkan kenyamanan pada pasien serta mempercepat proses penyembuhan.Kata kunci: Alergi, stomatitis venenata, zink fosfat ABSTRACTIntroduction: One type of hypersensitivity reaction that can occur in the oral cavity is Stomatitis venenata or also called allergic contact stomatitis. Venenata stomatitis is very rare and is rarely recognised by dentists. Venenata stomatitis can occur due to allergic reactions but is often ignored and causes misdiagnoses. As a result of misdiagnosis will cause treatment errors in patients. The purpose of this case report is to describe the case of Stomatitis venenata related to zinc phosphate allergy and its management, at the Dental and Oral Hospital of Jenderal Soedirman University. Case report: A 25-year-old man came complaining of canker sores on the left inner cheek near the gums that had been sore since 5 days ago accompanied by a scab on the left cheek. Extraoral examination results on the left cheek contained lesions in the form of multiple crusts that have dried, while the results of intraoral examination found reddish lesions on the left buccal mucosa. The lesion is suspected to arise due to zinc phosphate cementation material that touches the buccal mucosa. The clinical diagnosis is stomatitis venenata which is caused by an allergy to zinc phosphate exposure in the area around the lesion. Management is to eliminate allergens that are suspected of causing allergic reactions and administration of topical corticosteroid drugs to reduce pain. Venenata stomatitis lesions gradually recover after treatment. Conclusion: Stomatitis venenata by removing allergens and then replacing them with other ingredients shows an improvement in the patient's oral mucosa, besides the administration of topical corticosteroid drugs to improve patient comfort and speed up the healing process.Keywords: Allergy, stomatitis venenata, zinc phosphate
Dimensi vertikal oklusal, posisi kondilus mandibula terhadap fossa glenoidalis, dan kurva Spee sebelum dan sesudah insersi gigi tiruan lengkapOcclusal vertical dimension, mandibular condyle position on glenoid fossa and curve of Spee before and after insertion of complete denture Rinawati Satrio; Fanni Kusuma Djati; Annida Fatiya Zahra
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 2 (2019): Agustus 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.495 KB) | DOI: 10.24198/jkg.v31i1.18534

Abstract

Pendahuluan: Konstruksi Gigi Tiruan Lengkap (GTL) perlu memperhatikan hubungan dalam arah vertikal (dimensi vertikal) dan horizontal (relasi sentrik). Posisi kondilus pada fossa glenoidalis merupakan salah satu parameter untuk menentukan relasi sentrik. Kurva Spee pada penyusunan gigi tiruan juga penting untuk diperhatikan, karena akan menentukan kontak gigi posterior. Metode Niswonger banyak digunakan karena metodenya sesuai dengan karakteristik fisik keturunan asli Indonesia. Parameter objektif melalui radiografi sefalometri diperlukan untuk mengevaluasi secara lebih akurat. Kesalahan pada proses pembuatan GTL dapat membuat adanya perubahan pada Dimensi Vertikal Oklusal (DVO), posisi kondilus terhadap fossa glenoidalis, dan kurva Spee dalam proses pembuatan GTL. Tujuan penelitian adalah untuk membandingkan DVO, posisi kondilus terhadap fossa glenoidalis, dan kurva Spee sebelum dan sesudah insersi GTL. Metode: Jenis penelitian ini adalah penelitian kuantitatif dengan metode observasional analitik dan rancangan penelitian studi cross sectional. Hasil: Hasil uji dependent t-test menunjukkan adanya perubahan dalam bentuk penurunan yang signifikan pada DVO (p<0,05), serta adanya perubahan rata-rata posisi kondilus terhadap fossa glenoidalis dan kurva Spee antara sebelum dan sesudah insersi gigi tiruan lengkap. Simpulan: Terdapat perubahan DVO, posisi kondilus terhadap fossa glenoidalis, serta kurva Spee sebelum dan sesudah insersi gigi tiruan lengkap.Kata kunci: Dimensi vertikal oklusal, gigi tiruan lengkap, kurva Spee, metode Niswonger, posisi kondilus, fossa glenoidalis.  ABSTRACTIntroduction: Complete denture fabrication needs to pay attention to the relationship in the vertical direction (vertical dimension) and horizontal (centric relation). The position of the condyle in the glenoid fossa is one of the parameters for determining centric relations. The curve of Spee in the preparation of dentures is also important to note because they will determine the contact of the posterior teeth. Niswonger method is widely used because the method is following the physical characteristics of native Indonesian descendants. Objective parameters through cephalometric radiography are needed to evaluate more accurately. Errors in the process of making complete denture can make changes to the Occlusal Vertical Dimension (OVD), the position of the condyle against the glenoidal fossa, and the Spee curve in the process of making complete denture. The study was aimed to compare OVD, condyle position on glenoid fossa and curve of Spee before and after insertion of complete denture. Methods: The type of this research was quantitative research with observational analytic method and cross-sectional study design. Results: The results of the dependent t-test showed a change in the form of a significant decrease in OVD (p < 0.05), as well as an average change in the position of the condyle against the glenoidal fossa and the curve of Spee between before and after the insertion of complete dentures. Conclusion: There was a change in OVD, condyle position on glenoid fossa and curve of Spee before and after insertion of complete denture.Keywords: Occlusal vertical dimension, complete denture, the curve of Spee, Niswonger method, condyle position, glenoid fossa.
Perbandingan dimensi vertikal oklusal sebelum dan setelah insersi gigi tiruan lengkap dengan metode Niswonger dan radiografi sefalometriComparison of occlusal vertical dimension before and after complete denture insertion using Niswonger and cephalometric radiography methods Annida Fatiya Zahra; Ady Soesetijo; Fanni Kusuma Djati
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 1 (2019): April 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.61 KB) | DOI: 10.24198/jkg.v31i1.18536

Abstract

Pendahuluan: Konstruksi Gigi Tiruan Lengkap (GTL) perlu memperhatikan dimensi vertikal yang dibagi menjadi Dimensi Vertikal Oklusal (DVO) dan Dimensi Vertikal Fisiologis (DVF). Metode penentuan DVO yang dianggap relevan untuk masyarakat Indonesia adalah metode Niswonger dan radiografi sefalometri. Tujuan penelitian adalah untuk menganalisis DVO sebelum dan setelah insersi GTL dengan pendekatan metode Niswonger dan radiografi sefalometri. Metode: Jenis penelitian ini adalah kuantitatif dengan metode observasional analitik dengan rancangan studi cross sectional. Sampel adalah pasien di Rumah Sakit Gigi dan Mulut (RSGM) Universitas Jenderal Soedirman (Unsoed) Purwokerto yang dipilih dengan metode purposive total sampling sesuai dengan kriteria inklusi dan eksklusi. Seluruh subjek penelitian dilakukan pengukuran DVO sebelum insersi GTL menggunakan metode Niswonger dan radiografi sefalometri. Setelah tahapan prosedur pembuatan GTL selesai dan dilakukan insersi maka dihitung kembali DVO paska insersi menggunakan metode yang sama. Hasil pengukuran DVO sebelum dan setelah insersi gigi tiruan lengkap dibandingkan dan dianalisis. Hasil: Hasil uji dependent t-test menunjukkan adanya perbedaan yang signifikan antara DVO sebelum dan setelah insersi gigi tiruan lengkap pada pendekatan metode Niswonger dan radiografi sefalometri (p < 0,05). Simpulan: Terdapat penurunan dimensi vertikal oklusal sebelum dan setelah insersi GTL dengan pendekatan metode Niswonger dan radiografi sefalometri.Kata kunci: Gigi tiruan lengkap, dimensi vertikal oklusal, metode Niswonger, metode radiografi sefalometri. ABSTRACTIntroduction: Construction of complete denture needs to be emphasised on the vertical dimensions which are divided into Occlusal Vertical Dimensions (OVD) and Physiological Vertical Dimensions (PVD). The method of determining the OVD that is considered relevant for Indonesian is the Niswonger and cephalometric radiography methods. This study was aimed to analyse the OVD before and after complete denture insertion with the Niswonger and cephalometric radiography methods. Methods: This research was quantitative with an observational analytic method and cross-sectional study design. Samples were patients at the University of Jenderal Sudirman (Unsoed) Purwokerto Dental Hospital (RSGM) who were selected by purposive total sampling method according to inclusion and exclusion criteria. All study subjects were measured the OVD before complete denture insertion using the Niswonger and cephalometric radiography methods. After the procedure of complete denture fabrication was completed and insertion carried out, the post-insertion OVD was then remeasured using the same methods. The results of OVD measurements before and after complete denture insertion were then compared and analysed. Results: The results of dependent t-test showed a significant difference in the OVD before and after complete denture insertion with the Niswonger and cephalometric radiography methods (p < 0.05). Conclusion: There was a decrease in the occlusal vertical dimensions before and after complete denture insertion with the Niswonger and cephalometric radiography methods. Keywords: Complete denture, occlusal vertical dimension, Niswonger method, cephalometric radiography method.
Laporan Kasus: Tatalaksana Hematoma Akibat Trauma Fanni Kusuma Djati; Chrystina Kusuma Dewi
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 2 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i2.17933

Abstract

Hematoma is a large collection of extravasation of blood due to trauma, causing a palpable mass. The cause of hematoma is usually due to trauma or due to a systemic bleeding disorder. The differential diagnosis of this lesion is ecchymosis and hemangioma. A strong examination and history are needed to determine the diagnosis. Hematomas usually do not require treatment because of self-limiting. A 19-year-old woman came for control after 1 week of cleaning tartar/scaling. There was a swelling that the patient does not realize is under the dark red tongue with a size of ± 2mm. The patient had no history of systemic disease. OHI-S is good and other objective examinations are within normal limits. Therapy was given in the form of dental health education and evaluation of lesions for ± 1 week. Hematomas were generally caused by trauma resulting in extravasation of blood to the tissues that affect the underlying blood vessels. Hematoma could disappear spontaneously so there is no need for treatment.
Laporan Kasus: Petekie pada Rongga Mulut Akibat Faktor Iatrogenik pada Pasien Anak Helmi Hirawan; Fanni Kusuma Djati; Eliska Reza Mulitasari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 17 No 2 (2020)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v17i2.25220

Abstract

Petechiae are round red lesions with a diameter of less than 2 mm located in the subcutaneous tissue or submucosa. Locations that often occur are the buccal mucosa, cheeks, lips, lateral tongue, base of the tongue, palate, oropharynx. The etiologic factors of petechiae consist of two types, local factors and systemic factors. Local factors that cause petechiae such as trauma, injury, fellatio, iatrogenic trauma. Systemic factors that cause petechiae such as platelet abnormalities, blood clotting factor disorders, blood vessel damage. An 8-year-old woman with her parents came to RSGMP Unsoed with complaints of red spots on the floor of the mouth, the patient was not aware of the redness under the tongue before treatment on the right lower tooth, did not feel pain and did not feel disturbed by this condition, The patient stated that this had never happened before. The patient is undergoing dental pulpotomy. Petechiae caused by trauma can heal by eliminating the etiologic factor.
EKSTRAK DAUN PILADANG (Solenostemon scutellarioides (l.) codd) MENURUNKAN KADAR PROCALCITONIN DAN FGF-2 SALIVA PADA TIKUS WISTAR MODEL PERIODONTITIS KRONIS Christiana Cahyani Prihastuti; Ario Ditto Primandaru; A Haris Budi Widodo; Tuti Sri Suhesti; Fanni Kusuma Djati; Amilia Ramadhani; Rinawati Satrio
Mandala Of Health Vol 16 No 1 (2023): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2023.16.1.8386

Abstract

Periodontitis kronis merupakan inflamasi jaringan periodontal yang disebabkan oleh biofilm bakteri plak dan ditandai dengan pembentukan poket periodontal, resesi gingiva, resorpsi tulang alveolar yang berakibat pada kegoyangan gigi. Perawatan utama periodontitis kronis adalah scaling root planing (SRP) untuk menghilangkan bakteri sebagai etiologi utama namun seringkali membutuhkan terapi adjuvant. Pengembangan terapi adjuvant dari bahan alami diharapkan dapat mengurangi efek samping, salah satunya daun piladang yang diketahui mengandung senyawa aktif seperti flavonoid, saponin, serta tanin. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun piladang terhadap kadar procalcitonin dan fibroblast growth factor-2 (FGF-2) saliva pada tikus model periodontitis kronis. Dua puluh lima tikus Wistar jantan 2-3 bulan, berat badan 150-200 gram dan dibagi menjadi 5 kelompok, yaitu kelompok periodontitis kronis dengan perlakuan ekstrak daun piladang dosis 150 mg/kg BB, 300 mg/kg BB, dan 600 mg/kg BB (P1, P2, P3), kelompok periodontitis kronis dengan perlakuan Na-CMC 1% (kontrol negatif/ KN), serta kontrol sehat (KS). Perlakuan selama tiga hari dilanjutkan pengambilan sampel saliva pada hari ke-empat. Kadar procalcitonin dan FGF-2 saliva diukur dengan uji ELISA. Analisis statistic menggunakan uji One-Way Anova dilanjutkan Post hoc LSD. Hasil menunjukkan penurunan kadar procalcitonin dan FGF-2 saliva pada kelompok perlakuan ekstrak daun piladang (P1, P2, P3) seiring peningkatan konsentrasi ekstrak, berbeda signifikan daripada kontrol negatif (p≤0,05), dan menyamai kondisi sehat (p>0,05). Hal ini mengindikasikan ekstrak daun piladang dapat mempercepat fase inflamasi dan proliferasi pada tikus model periodontitis kronis.
POTENTIAL OF RED ONION PEEL ETHANOL EXTRACT (Allium cepa L.) TO DEGRADATION OF Staphylococcus aureus BIOFILM Sari, Dwi Nur Indah; Rosyada, Alya Ghina; Laksitasari, Anindita; Djati, Fanni Kusuma; Andini, Restian Febi
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11371

Abstract

Dental biofilm is a bacterial colonization adhering to the tooth surface, enveloped by an extracellular matrix. This biofilm shields bacteria from the body's defense and antibacterial systems, potentially leading to various dental and oral diseases.Staphylococcus aureus is among the bacteria forming dental biofilm. Red onion peel is known to contain flavonoids, saponins, tannins, steroids and alkaloids which have antibacterial and anti-biofilm activity. This study aimed to determine the potential of shallot peel extract in degrading S. aureus biofilms. This study was conducted with a posttest-only control group design. Red onion peel extraction is carried out using the maceration method. A total of 5 groups of extracts (50%, 25%, 12.5%, 6.25%, and 3.12%), positive control (chlorhexidine gluconate 0.2%), and negative control (DMSO 1%) were tested for their activity in S. aureus biofilm degradation at 24 and 48 hours of incubation. The biofilm degradation was assessed using the microtiter plate assay method with crystal violet staining read at a wavelength of 595 nm. Percent biofilm degradation was statistically analyzed using Two way ANOVA and LSD. The results indicated significant differences based on treatment, incubation time, and the interaction between the two. The highest activity was observed at a concentration of 25%, although it was still lower than that of positive control. Conclusion: the ethanol extract of red onion peel has the potential to degrade S. aureus biofilms, with the highest activity at a concentration of 25% and an incubation time of 48 hours.
Characterization and Drug Release Evaluation of Chlorhexidine-Encapsulated Silica Nanoparticles for Potential Root Canal Disinfection Rakhmawati, Widya; Harmaji, Andrie; Djati, Fanni Kusuma; Sunendar, Bambang
Makara Journal of Science
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The failure of root canal treatments is often attributed to bacterial invasion of the dentinal tubules, where pathogens can persist and complicate healing. Chlorhexidine digluconate, a potent antimicrobial agent, has been widely utilized for its broad-spectrum antibacterial effects. However, challenges remain in achieving efficient distribution and sustained release within the root canal system. This study investigates the encapsulation of chlorhexidine digluconate within silica nanoparticles as a novel drug delivery system that is aimed at improving root canal treatment outcomes. Silica nanoparticles were synthesized using the sol-gel method and subsequently immersed in a 2% chlorhexidine digluconate solution for 15 to 30 minutes to achieve encapsulation. The resulting materials were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and ultraviolet–visible (UV–Vis) spectroscopy. SEM analysis revealed particle sizes in the range of 80–150 nm for nanoparticles aged for 15 minutes and in the range of 250–350 nm for those aged for 30 minutes. FTIR spectroscopy confirmed the presence of functional groups characteristic of silica, chitosan, and sodium alginate, indicating successful encapsulation. The UV–Vis spectrophotometry demonstrated that silica nanoparticles aged for 30 minutes exhibited a more stable and controlled release of chlorhexidine digluconate (0.08 ppm) over a 60-minute period. This study presents a novel approach for enhancing root canal treatment, in which silica nanoparticles are utilized for controlled drug delivery. Additionally, the study shows that longer aging times may offer improved stability and efficacy in sustained antimicrobial action. The findings suggest that the use of silica-encapsulated chlorhexidine nanoparticles is a promising strategy for more effective endodontic treatment because it addresses bacterial invasion and supports long-term therapeutic effects.
Desquamative cheilitis in a patient with anemia of chronic : Keilitis deskuamatif pada pasien anemia penyakit kronis Djati, Fanni Kusuma; Rahmah, Faza Faizah Nur; Sarah, Putri; Aditiyono
Makassar Dental Journal Vol. 14 No. 2 (2025): Volume 14 Issue 2 August 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i2.1284

Abstract

Anemia of chronic disease (ACD) is a normochromic normocytic anaemia that occurs in patients with chronic diseases. Desqua-mative cheilitis is a condition of persistent inflammation and sloughing of the lips. This article presents the condition of desqua-mative glossitis in a patient with ACD, along with its manifestations, pathophysiology, and management in dentistry. A 48-year-old woman came to the emergency room of Prof. Dr. Margono Soekarjo Purwokerto Hospital on 27 September 2024 with the main complaint of shortness of breath since two days ago, accompanied by cough, chest pain, fever, enlarged abdomen, full-ness, and dry lips that bleed easily. The patient had a history of uterine myoma and had been curetted. The complete blood test showed that the patient had ACD. The patient was treated with blood transfusion therapy and pharmacological medication in the form of sterile infusions, antifibrinolytic injections, antifungal, antibacterial, and mutivitamins. It was concluded that ACD is an iron deficiency condition that can cause secondary infection in the form of desquamative cheilitis, treated by increasing iron in-take and stress management.
Antifungal Activity Test Ethanol Extract Of Awar-Awar Leaves (Ficus septica Burm. F.) to Candida tropicalis As The Cause of Oral Candidiasis In Vitro Bagus, Zahran Uzla Attaqi; Anjarwati, Dwi Utami; Djati, Fanni Kusuma; Ichsyani, Meylida
Jurnal Medali Vol 7, No 2 (2025): Media Dental Intelektual Agustus 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.136-144

Abstract

Background: Oral candidiasis is an infection in the oral cavity caused by Candida tropicalis, a non-Candida albicans (NCAC) species with the highest virulence. The first-line treatment for oral candidiasis is nystatin; however, it may cause side effects. One alternative treatment for oral candidiasis is the use of Ficus septica Burm. F. leaves, which contain active compounds such as saponins, tannins, flavonoids, and triterpenoids, all of which have potential antifungal properties. This study aims to evaluate the antifungal activity ethanol extract of awar-awar leaves to Candida tropicalis as the cause of Oral Candidiasis in vitro. Method: This experimental laboratory study used a posttest-only control group design, comparing the treatment groups with ethanol extract of Ficus septica burm. F leaves at concentrations of 4%, 8%, 16%, and 32% with a positive control group (nystatin) and a negative control group (Dimethyl sulfoxide). Antifungal activity was tested using the microdilution broth method to determine the Minimum Inhibitory Concentration (MIC) and the spread plate method to determine the Minimum Bactericidal Concentration (MBC). Colony growth of C. tropicalis was measured using the Total Plate Count (TPC) method, followed by calculating the inhibition percentage. Result: The analysis of this study showed that the MIC of Ficus septica Burm F leaf extract was at a concentration of 32%, and the MBC of the extract was also at a concentration of 32%, with a 100% inhibition percentage. Significant differences (p ≤ 0.05) were found between the concentrations of the ethanol extract of Ficus septica leaves.Conclussion: The conclusion of this study is that the ethanol extract of Ficus septica Burm. F leaves has antifungal activity in inhibiting the growth of C. tropicalis, the cause of oral candidiasis, with the most effective concentration being 32% with 100% inhibition.
Co-Authors A Haris Budi Widodo A. Haris Budi Widodo Aditiawarman Aditiawarman, Aditiawarman Aditiyono Ady Soesetijo Affan Wirutomo Amilia Ramadhani Andini, Restian Febi Annida Fatiya Zahra Annida Fatiya Zahra Ario Ditto Primandaru Bagus, Zahran Uzla Attaqi Bambang Sunendar Berlianza, Activira Christiana Cahyani Prihastuti Chrystina Kusuma Dewi Dewi, Aisha Tiara Dwi Nur Indah Sari Dwi Utami Anjarwati Eliska Reza Mulitasari Febriharsari, Niken Harmaji, Andrie Helmi Hirawan Ichsyani, Meylida Kinasih, Amelia Sekar Laksitasari, Anindita Minullah, Nanda Asta Naim, Cantika Nadrotan Nugroho, Yunanto Dwi Octivany, Sherly Rahmah, Faza Faizah Nur Rakhmawati, Widya Ramadhanti, Dian Praba Rinawati Satrio Rosyada, Alya Ghina Sarah, Putri Tuti Sri Suhesti