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Uji Efektivitas Ekstrak Dan Fraksi Daun Matoa Terhadap Antihipertensi Dan Antihiperkolesterolemia Secara In Vivo Andika, Miming; Febriana, Tita Adhaha; Aini, Latyfa’; Nanda, Nanda; Putra, Fajrian Aulia; Fitriani, Oryza Sativa
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4101

Abstract

Hiperkolesterolemia dan hipertensi merupakan penyakit kardiovaskular yang berbahaya. Beberapa faktor resiko bersifat permanen seperti usia, jenis kelamin, genetik dan faktor lainnya dapat dimodifikasi seperti merokok, kurangnya aktivitas fisik, gizi buruk, tekanan darah tinggi, diabetes tipe II, dislipidemia dan obesitas. Aterosklerosis dan hipertensi berpotensi berkembang menjadi penyakit kardiovaskular yang berbahaya seperti infark miokard dan stroke. Bahan alam banyak digunakan sebagai alternatif pengobatan kardiovaskular seperti daun matoa, daun matoa banyak digunakan sebagai oabat diabetes melitus, diare dan disentri. Tujuan penelitian ini adalah untuk melihat efektivitas dan pengaruh lama pemberian ekstrak dan fraksi daun matoa Pometia pinnata J. R Forst & G. Forst terhadap penurunan kolesterolemia dan hipertensi pada hewan uji. Pada penelitian ini menggunakan hewan uji berupa tikus dan burung puyuh. Pengukuran tekanan darah menggunakan instrumen CODA®, dan pengukuran kadar kolesterol meggunakan fotometer klinik. Hasil dari penelitian ini menunjukkan bahwa pemberian ekstrak daun matoa dapat mempengaruhi kadar kolesterolemia dengan dosis yang efektif 300 mg/kgbb, dan fraksi daun matoa mempengaruhi tekanan darah dengan dosis efektif Kesimpulan dari penelitian ini menyatakan ekstrak dan fraksi daun matoa dapat menurunkan kadar kolesterol dalam darah dan tekanan darah pada hewan percobaan serta semakin tinggi dosis yang diberikan maka semakin tinggi juga penurunannya.
Uji Efektivitas Fraksi Etil Asetat Eleutherine Bulbosa Terhadap Penurunan Kadar Kolesterol Total, Tekanan Darah Sistolik-Diastolik Pada Tikus Putih Jantan Fauzia, Haliza Diny; Andika, Miming; Sari, Putri Nilam; Hasanah, Rizqa; Putra, Fajrian Aulia; Fitriani, Oryza Sativa; Rahmadasmi, Nola
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4707

Abstract

Eleutherine Bulbosa is one of the plants cultivated by the community for traditional medicine. It's like lowering hypercholesterolemia. Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. Besides, it can also lower hypertension. Hypertension is a condition in which blood pressure exceeds the normal limit, with systolic pressure above 140 mmHg and diastolic blood pressure above 90 mmHg. The study aims to look at the effectiveness of the Eleutherine Bulbosa ethyl acetate fraction against the reduction in total cholesterol levels, systolic blood pressure, and diastolic blood pressure in male white rats. Animal cholesterol levels were raised using MLT for 22 days. Cholesterol parameters were tested using a Dumolab DC20 photometer. The inducer used to raise blood pressure is 8% NaCl for 14 days. Blood pressure is measured using non-invasive blood pressure. (NIBP). The results of the research showed that the flavonoid groups that play a role in lowering high cholesterol levels are the anthocyanins and quercetin, while the alkaloid compounds play a part in lowering high blood pressure. Data analysis showed significant results (p<0.05). It can be concluded that the administration of the ethyl acetate fraction Eleutherine Bulbosa is capable of lowering high cholesterol levels and high systolic-diastolic blood pressure.
Preparation And Evaluation Of Hydrogel From Super Red Dragon Fruit Skin Extract (Selenicereus costaricensis) Setiawan, Dwi; Yesti, Yulia; Rahmadasmi, Nola; Fitriani, Oryza Sativa; Andika, Miming; Hasanah, Rizqa; .AH, Ahdi Dinil Haq; Wulandari, Desti; Putri, Nurdina
JURNAL PROTEKSI KESEHATAN Vol 13 No 2 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i2.947

Abstract

Dragon skin is a waste that is rarely used and often discarded. The dragonfruit skin has antioxidant activity related to the anthocyanin content that protects the skin from oxidation damage to prevent premature aging. This study introduces a new approach to utilizing super red dragon fruit skin waste often thrown away, by formulating it into a hydrogel preparation with potential as a cosmetic product. An experimentally used method with a true-experimental design. There are 7 formulas, F1 (base), F2, F3, and F4 (with ultrasonic extract 1%, 2%, 3.). The evaluations included organoleptic tests, homogeneity tests, viscosity testing, pH tests, swelling ratio, freeze and thaw. The results of this study show that super red dragonfruit leather extracts can be formed in hydrogel preparations and have good physical quality properties.
ANALYSIS OF DEXAMETASONE LEVELS IN HERBAL WEIGHT GAIN MEDICINE CIRCULATING IN BUKITTINGGI CITY USING UV-VIS SPECTROPHOTOMETRY Fitriani, Oryza Sativa; Khaidir, Muhammad; Hasanah, Rizqa; Rahmadasmi, Nola; Andika, Miming
HUMAN CARE JOURNAL Vol 10, No 1 (2025): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v10i1.3333

Abstract

Chemical drugs are chemical substances added to traditional medicines or herbal medicines to strengthen the indications. One of the chemical drugs that is often added to herbal medicines is dexamethasone. With the presence of dexamethasone content that is intentionally added to herbal medicines, it can increase the weight of consumers who consume the herbal medicine. Dexamethasone in long-term use can cause unwanted hormonal effects, namely a series of changes called iatrogenic Cushing's Syndrome (moon face) and osteoporosis. This study aims to identify the chemical drug dexamethasone in weight-gaining herbal medicines sold in the city of Bukittinggi using purposive sampling techniques and analyzing its levels. The research method was carried out using UV-Vis spectrophotometry. The results of the study showed that there were 2 samples of herbal weight gain medicines that positively contained dexamethasone with a concentration of 1.9771% in herbal medicine 2 and 0.2092% in herbal medicine 7. In conclusion, out of 10 herbal weight gain medicines sold in Bukittinggi City, there were 2 herbal medicine samples that contained the chemical drug dexamethasone.