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All Journal Global Medical and Health Communication The International Journal of Medical Science and Health Research
Yumilia, Hoo
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet Jasaputra, Diana Krisanti; Yumilia, Hoo; Gunadi, Julia Windi; Lesmana, Ronny; Permadi, Andieni Faqhira
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10993

Abstract

High levels of fat in the blood are a risk factor for nonalcoholic steatohepatitis liver disease. Indonesian medicinal plants that can decrease blood fat levels are turmeric and mangosteen peel. One of the mechanisms of blood fat-lowering drugs is to increase the expression of the PPARα gene. The purpose of this study was to assess the effect of turmeric and mangosteen peel on the expression of the PPARα gene in the rat liver induced by a high-fat diet. This research was conducted at Maranatha Biomedical Research Laboratory in February–October 2021, using male Wistar rats that were divided into 5 groups (n=5): negative control groups (no treatment), positive control groups (high-fat diet), turmeric, mangosteen, and fenofibrate groups, that was given high-fat diet continued by ethanol extract of turmeric, ethanol extract of mangosteen peel, and fenofibrate. At the end of the study, the animals were terminated, and the liver was extracted for RNA extraction and semi-quantitative PCR. The results showed that there was an increase in PPARα gene expression in the turmeric group and fenofibrate group, which were significantly different from the positive control group that received a high-fat diet (p<0.05) and between the fenofibrate group compared to negative controls that received standard chow diet (p<0.05). In conclusion, turmeric and fenofibrate are suggested to increase the expression of the PPARα gene in the liver induced by a high-fat diet.
Effects of Melatonin Supplementation in Type 2 Diabetes Mellitus Setiawan Nathan, Daniel; Yumilia, Hoo
The International Journal of Medical Science and Health Research Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Abstract

Background: Diabetes mellitus, a metabolic illness causing hyperglycemia, is primarily caused by insulin resistance. Melatonin, an indolamine, plays a role in the circadian cycle and affects hunger, fullness, and awareness. Melatonin treatment has shown positive effects on glycated hemoglobin, fasting plasma glucose, and insulin levels, but may increase insulin sensitivity and reduce fasting insulin levels. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues. Result: Our study team initially collected more than 100,000 publications using reliable sources including Science Direct, PubMed, and SagePub. Just five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. To facilitate viewing, Table 1 gathers together the literature that was examined for this analysis. Conclusion: Melatonin, a hormone, can affect glycemic control, obesity control, and energy expenditure. It regulates insulin secretion and protects against reactive oxygen species and free radicals. However, high levels can negatively affect insulin sensitivity.
Association of Selenium and Thyroid Cancer: A Comprehensive Systematic Review Setiawan Nathan, Daniel; Yumilia, Hoo
The International Journal of Medical Science and Health Research Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Introduction: Selenium's historical journey from discovery to its role in human health underscores its complex relationship with disease, particularly thyroid cancer. While research suggests a potential link between low selenium levels and thyroid cancer risk, conflicting findings challenge our understanding of selenium's impact, warranting further investigation. This systematic review aims to unravel selenium's intricate interplay with thyroid cancer, navigating through its historical significance, physiological role, and recent epidemiological studies to offer insights into this complex relationship. Method: The researchers in this study followed the 2020 Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines to ensure that their work met the required standards. This was done to ensure the precision and reliability of the conclusions derived from the research. Result: Our search produced 18 results. After looking at the titles and summaries, we found 7 papers that fit our criteria. At first, we excluded several articles because they were written in review style, pilot study, and case reports. But after reading the full papers carefully, we included five papers in our final analysis. These papers included experimental study, cross-sectional study, prospective cohort, and case control. Conclusion: This systematic review explores the relationship between selenium and thyroid cancer, highlighting SBP1 as a potential therapeutic target based on experimental evidence. Clinical studies suggest lower serum selenium levels in females with papillary thyroid cancer, indicating a potential protective effect with higher selenium levels. While the development of a tumor-targeted drug delivery system shows promise for thyroid cancer treatment, a large prospective cohort study found no association between selenium intake and thyroid cancer risk, emphasizing the need for further research, particularly biomarker-based studies.
Association of Metabolic Syndrome and Risk or Development of Chronic Kidney Disease: A Comprehensive Systematic Review Setiawan Nathan, Daniel; Yumilia, Hoo
The International Journal of Medical Science and Health Research Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Background: Metabolic syndrome (MetS) encompasses a cluster of metabolic abnormalities including hypertension, hyperlipidemia, hyperuricemia, hyperglycemia, central obesity, and insulin resistance. MetS and chronic kidney disease (CKD) are intricately linked and can influence each other. This study aims to serve a comprehensive systematic review to evaluate the association of MetS and CKD in literatures of the last 10 years.   Methods: The review adhered to PRISMA 2020 standards and analyzed full-text English literature from 2014 to 2024. It excluded editorials, review papers from the same journal, and submissions lacking a DOI. Literature sources included PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 488 articles were retrieved from online databases (PubMed, SagePub, SpringerLink and Google Scholar). After three rounds of screening, five articles directly relevant to the systematic review were selected for full-text reading and analysis. Conclusion: The discussion emphasizes the complex link between metabolic syndrome (MetS) and chronic kidney disease (CKD), driven by modern lifestyle habits causing metabolic overload. Kidneys are especially susceptible to MetS effects, but effective treatment strategies are lacking. Further research is needed to understand and address MetS-related kidney damage.
Co-Authors Diana Krisanti Jasaputra Gunadi, Julia Windi Permadi, Andieni Faqhira Ronny Lesmana Setiawan Nathan, Daniel