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All Journal Global Medical and Health Communication Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Permadi, Andieni Faqhira
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet Jasaputra, Diana Krisanti; Yumilia, Hoo; Gunadi, Julia Windi; Lesmana, Ronny; Permadi, Andieni Faqhira
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10993

Abstract

High levels of fat in the blood are a risk factor for nonalcoholic steatohepatitis liver disease. Indonesian medicinal plants that can decrease blood fat levels are turmeric and mangosteen peel. One of the mechanisms of blood fat-lowering drugs is to increase the expression of the PPARα gene. The purpose of this study was to assess the effect of turmeric and mangosteen peel on the expression of the PPARα gene in the rat liver induced by a high-fat diet. This research was conducted at Maranatha Biomedical Research Laboratory in February–October 2021, using male Wistar rats that were divided into 5 groups (n=5): negative control groups (no treatment), positive control groups (high-fat diet), turmeric, mangosteen, and fenofibrate groups, that was given high-fat diet continued by ethanol extract of turmeric, ethanol extract of mangosteen peel, and fenofibrate. At the end of the study, the animals were terminated, and the liver was extracted for RNA extraction and semi-quantitative PCR. The results showed that there was an increase in PPARα gene expression in the turmeric group and fenofibrate group, which were significantly different from the positive control group that received a high-fat diet (p<0.05) and between the fenofibrate group compared to negative controls that received standard chow diet (p<0.05). In conclusion, turmeric and fenofibrate are suggested to increase the expression of the PPARα gene in the liver induced by a high-fat diet.
Peran Alfamangostin dalam Minyak Jagung dalam Memperbaiki Profil Lipid pada Tikus yang Diinduksi Pakan Tinggi Lemak Tjahjani, Susy; Jasaputra, Diana Krisanti; Permadi, Andieni Faqhira; Hidayat, Ester; Sitepu, Valerie Caroline; Radithya, Putu Audiva
Majalah Kedokteran Indonesia Vol 74 No 1 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.1-2024-856

Abstract

Introduction: Alphamangostin is a component of the mangosteen peel extract (Garcinia mangostana L) that has potential as a therapy for dyslipidemia. However, alphamangostin has low solubility, resulting in low bioavailability when administered orally. This study aims to investigate the potential of alphamangostin dissolved in corn oil on serum lipid profiles in vivo.Methods: The study was conducted on 24 Sprague Dawley strain Rattus norvegicus rats divided into 6 treatment groups (NC, HFD, CO, D1, D2, and Sim), with 4 rats each group randomly assigned. After a 1-week acclimatization period, each group received the following treatments: standard diet for 4 weeks (NC), high-fat diet + propylthiouracil (PTU) for 4 weeks (HFD), HFD + corn oil (CO), HFD + alphamangostin in corn oil at 7 mg/KgBW (D1), HFD + alphamangostin in corn oil at 35 mg/KgBW (D2), and HFD + simvastatin at 3.6 mg/KgBW (Sim). Treatments for CO, D1, D2, and Sim were administered for 2 weeks. Serum total cholesterol, HDL, LDL, and triglycerides were examined before and after treatment, and the differences were analyzed statistically.Results: The administration of alphamangostin at a dose of 7 mg/KgBW (D1) and corn oil (CO) significantly decreased LDL cholesterol levels (p less than 0.05), and alphamangostin at a dose of 35 mg/KgBW (D2) significantly decreased triglyceride levels (p less than 0.05). Meanwhile, there were decreases in total cholesterol levels and increases in HDL cholesterol levels in the alphamangostin and corn oil groups, but these changes were not statistically significant (p greater than 0.05).Conclusions: Alphamangostin can reduce LDL cholesterol and triglyceride levels in high-fat diet-induced rats.
Co-Authors Diana Krisanti Jasaputra Gunadi, Julia Windi Hidayat, Ester Radithya, Putu Audiva Ronny Lesmana Sitepu, Valerie Caroline Susy Tjahjani Yumilia, Hoo