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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology And Pharmacy Scientific Journals (PAPS Journals)
Hakim, Azima
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Effects of Combination of Cisplatin and Paclitaxel Chemotherapy on Tumor Mass in Nasopharyngeal Carcinoma Patients at Dr. Wahidin Sudirohusodo Hospital Makassar with the RECIST Method: Efek Kombinasi Kemoterapi Cisplatin dan Paclitaxel Terhadap Massa Tumor pada Pasien Karsinoma Nasofaring di RSUP Dr. Wahidin Sudirohusodo Makassar dengan Metode RECIST Hakim, Azima; Wahyudin, Elly; Pieter, Nova Audrey Luetta
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16236

Abstract

Background: Nasopharyngeal Carcinoma (NPC) is a malignant tumor that grows from epithelial cells that line the surface of the nasopharynx and has a tumor position close to the base of the skull, vital structures, and anatomical locations that are difficult to reach and various symptoms are the cause of increased patient mortality and morbidity rates. This research aims to identify the most effective chemotherapy effect on reducing tumor mass in nasopharyngeal cancer patients. Material and Methods: This study was conducted retrospectively based on patient medical record data from January 2019 to December 2021 at Dr. Wahidin Sudirohusodo General Hospital. Inclusion criteria included NPC patients who received cisplatin, carboplatin, paclitaxel, and docetaxel chemotherapy and had complete data on tumor mass size before and after receiving chemotherapy from Series I to Series VI. The resulting assessment of tumor mass size was further categorized using RECIST. Results: A total of 166 NPC patients met the inclusion criteria. The results of the study obtained that NPC patients suffered more in men than women, most NPC patients were aged (41-50), Stage IVA had the highest percentage found in NPC patients, Histopathology based on WHO type III was most commonly found in 109 patients, 70 patients used the Cisplatin+Paclitaxel chemotherapy regimen, 55 patients used the Cisplatin+Paclitaxel chemotherapy regimen had a partial tumor mass response. Conclusions: The combination of Cisplatin + Paclitaxel has the most partial response to the tumor mass of NPC patients at Wahidin Sudirohusodo General Hospital, Makassar.
FORMULASI DAN UJI AKTIVITAS TABIR SURYA SEDIAAN BODY LOTION FRAKSI ETIL ASETAT DAUN SINTRONG (Crassocephalum crepidioides) Hakim, Azima; Bu’tu, Yulita; Aliah, Ahmad Irsyad; Setiawan, Prayitno
Pharmacology And Pharmacy Scientific Journals Vol. 4 No. 2: Desember, 2025, PAPS
Publisher : Unit Publikasi Ilmiah Perkumpulan Intelektual Madani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51577/papsjournals.v4i2.777

Abstract

Daun sintrong (Crassocephalum crepidioides) merupakan tumbuhan yang mengandung senyawa aktif seperti flavonoid dan polifenol yang dapat dimanfaatkan sebagai antioksidan, khususnya terhadap bahaya sinar UV. Penelitian ini bertujuan membuat formula body lotion fraksi etil asetat daun sintrong dengan menguji evaluasi fisik, stabilitas, serta aktivitas tabir surya menggunakan spektrofotometri UV-Vis. Uji dilakukan pada empat konsentrasi: 0% (K-), 0,1% (F1), 0,2% (F2), dan 0,3% (F3). Pada uji evauasi fisik diperoleh F1, F2, dan F3 berwarna hijau muda, hijau, dan hijau tua, sedangkan K- berwarna putih. Semua formulasi beraroma citrus lemon, berbentuk semi padat, homogen, dan memenuhi syarat nilai pH, daya lekat, daya sebar, dan viskositas. Hail uji aktivitas tabir surya sediaan body lotion fraksi etil asetat daun sintrong menunjukkan nilai SPF untuk konsentrasi 0,1% adalah 3,27 (minimal), 0,2% adalah 5,33 (sedang), dan 0,3% adalah 5,53 (sedang). Nilai %Te untuk F1, F2, dan F3, secara berurutan adalah 45,5%, 29,17%, dan 27,72%, sedangkan %Tp adalah 72,06%, 47,33%, dan 41,99%, yang belum memenuhi klasifikasi tabir surya. Konsentrasi 0,3% merupakan konsentrasi optimum dengan nilai SPF 5,59 (proteksi sedang), %Te 27,72%, dan %Tp 42,99%.
Co-Authors Aliah, Ahmad Irsyad Bu’tu, Yulita Djamadin, Iciyanti Elly Wahyudin Ikbal Ikbal Pieter, Nova Audrey Luetta Setiawan, Prayitno Sri Wahyuningsih Sudirman, Agriawan wahyuni wahyuni