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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biologi Tropis Jurnal Riset Multidisiplin : Agrisosco
Pieter, Nova Audrey Luetta
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences

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Effects of Combination of Cisplatin and Paclitaxel Chemotherapy on Tumor Mass in Nasopharyngeal Carcinoma Patients at Dr. Wahidin Sudirohusodo Hospital Makassar with the RECIST Method: Efek Kombinasi Kemoterapi Cisplatin dan Paclitaxel Terhadap Massa Tumor pada Pasien Karsinoma Nasofaring di RSUP Dr. Wahidin Sudirohusodo Makassar dengan Metode RECIST Hakim, Azima; Wahyudin, Elly; Pieter, Nova Audrey Luetta
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16236

Abstract

Background: Nasopharyngeal Carcinoma (NPC) is a malignant tumor that grows from epithelial cells that line the surface of the nasopharynx and has a tumor position close to the base of the skull, vital structures, and anatomical locations that are difficult to reach and various symptoms are the cause of increased patient mortality and morbidity rates. This research aims to identify the most effective chemotherapy effect on reducing tumor mass in nasopharyngeal cancer patients. Material and Methods: This study was conducted retrospectively based on patient medical record data from January 2019 to December 2021 at Dr. Wahidin Sudirohusodo General Hospital. Inclusion criteria included NPC patients who received cisplatin, carboplatin, paclitaxel, and docetaxel chemotherapy and had complete data on tumor mass size before and after receiving chemotherapy from Series I to Series VI. The resulting assessment of tumor mass size was further categorized using RECIST. Results: A total of 166 NPC patients met the inclusion criteria. The results of the study obtained that NPC patients suffered more in men than women, most NPC patients were aged (41-50), Stage IVA had the highest percentage found in NPC patients, Histopathology based on WHO type III was most commonly found in 109 patients, 70 patients used the Cisplatin+Paclitaxel chemotherapy regimen, 55 patients used the Cisplatin+Paclitaxel chemotherapy regimen had a partial tumor mass response. Conclusions: The combination of Cisplatin + Paclitaxel has the most partial response to the tumor mass of NPC patients at Wahidin Sudirohusodo General Hospital, Makassar.
Osteoma Raksasa Sinus Maksilaris dan Etmoidalis: Kasus Jarang Johansyah, Lydia Christina; Irwansyah, Andi Cakra; Pieter, Nova Audrey Luetta; Djamin, Riskiana; Syahrijuita, Syahrijuita; Alimah, Yarni
Jurnal Riset Multidisiplin Agrisosco Vol 2, No 3 (2024): Vol 2 No 3 Desember 2024
Publisher : Lembaga Penelitian, Pengembangan, Pemberdayaan Potensi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61316/jrma.v2i3.96

Abstract

Osteoma digambarkan sebagai pertumbuhan tulang matur yang berkembang lambat dan berlebihan, terletak khas pada tulang dengan osifikasi intramembran, seperti tulang tengkorak. Osteoma sinus paranasalis tidak menunjukkan gejala hingga massa tumor mencapai ukuran tertentu. Diagnosa osteoma sinus paranasalis sering ditegakkan secara insidentil saat evaluasi radiologik untuk masalah lain. Penanganan utama pada osteoma sinus paranasalis simptomatik adalah dengan bedah endoskopik atau pendekatan eksternal. Tujuan penelitian untuk berbagi pengetahuan tentang penanganan bedah pada pasien dengan osteoma sinus maksilaris dan etmoidalis. Laporan kasus: Seorang laki-laki umur 16 tahun dengan keluhan obstruksi nasi ada sebelah kanan dialami sejak 9 bulan terakhir. Sebelumnya terdapat keluhan pada gigi yang ingin dicabut kemudian dilakukan pemeriksaan foto panoramik dan ditemukan kelainan lalu dirujuk ke dokter THT. Pada pemeriksaan rinoskopi anterior dextra tampak massa berwarna putih, konsistensi keras, tidak mudah berdarah, yang menyempitkan cavum nasi dextra. Pemeriksaan CT scan sinus paranasalis didapatkan hasil massa hiperdens cavum nasi yang melibatkan sinus maxillaris dan sinus ethmoidalis kanan yang menyempitkan choanae sugestif giant osteoma, osteoma sinus ethmoidalis kiri, multisinusitis dan deviasi septum nasi ke kiri. Pada intraoperatif tampak massa konsistensi keras berwarna putih pada cavum maksila dan etmoid dextra. Manajemen: Pasien ini dilakukan operasi maksilektomi medial dengan pendekatan rinotomi lateral diperluas dengan insisi Weber-Ferguson. Penulusuran literatur pada Pubmed dengan kata kunci yang sesuai. Kami melaporkan sebuah kasus jarang berupa osteoma raksasa pada sinus maksilaris dan etmoidalis. Penanganan dilakukan dengan operasi maksilektomi medial dengan pendekatan rinotomi lateral diperluas dengan insisi Weber-Ferguson.
Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus) Makbul, Hidayat; Wedayani, Anak Agung Ayu Niti; Punagi, Abdul Qadar; Pieter, Nova Audrey Luetta; Cangara, Muhammad Husni; Lestarini, Ima Arum; Restuningdyah, Novia Andansari Putri
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6455

Abstract

Formaldehyde is a hazardous chemical substance that can be found commonly in the environment which has various effects on cellular functions and could induce the cellular oxidative stress. Oxidative stress has a direct impact on the hepatic condition and could induce the activation of inflammatory mediators, lipid peroxidation, proteosomal degradation, and mitochondrial dysfunction resulting in hepatocyte injury that could be marked by hepatic enzyme elevation and hepatic weight alterations. This research was conducted using 16 Wistar rats (Rattus norvegicus), divided into 4 groups each containing 4 Wistar rats. The first group was the control group, while the other groups were exposed to formaldehyde 10% by inhalation at doses of 20, 30, and 40 ppm formaldehyde persistently for 6 hours daily for about 16 weeks. The result of this study reveals that formaldehyde induction has a significant impact on hepatic weight elevations (p=0.007) and ALT enzyme elevations (p=0.000) in the treatment groups compared with the control group. Collectively, our results provide valuable information on the hazardous effects of formaldehyde inhalation, especially on the liver.
Inhaled Formaldehyde Induction Effect on Urea and Creatinine Levels of Wistar Rats (Rattus Norvegicus) Ramadhita, Nova Izza Salsa; Lestarini, Ima Arum; Wedayani, Anak Agung Ayu Niti; Punagi, Abdul Qadar; Pieter, Nova Audrey Luetta; Cangara, Muhammad Husni
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6457

Abstract

Formaldehyde is a chemical substance that has the molecular formula H2-C=O. These chemicals are frequently present in the form of contaminants in the outdoor environment. Previous research has been undertaken to investigate the effects of formaldehyde inhalation on various organs such as the nasopharynx, upper respiratory tract, and lungs. The purpose of this study is to determine the effect of inhaled formaldehyde exposure on kidney function. The parameters of the kidney function tests that were measured were urea and creatinine levels in the rat's blood serum. For 16 weeks, 12 male Wistar rats were used in an experimental investigation with a post-test-only control group design. The rats were divided randomly control and treatment groups. Treatment group exposed to 10% formaldehyde levels as high as 40 ppm by inhalation. Blood serum samples were obtained through the retro orbit at week 16 and analyzed using a UV VIS spectrophotometer. According to data analysis utilizing the Independent T-test, there was a significant difference in the urea content test data (p < 0.05). Mann-Whitney analysis of creatine data revealed that there is no significant difference between the groups. From the statistical analysis, it can be concluded that formaldehyde exposure has an effect on increasing urea levels and has no effect on creatinine levels.
Co-Authors Abdul Qadar Punagi Alimah, Yarni Anak Agung Ayu Niti Wedayani Cangara, Husni Elly Wahyudin Hakim, Azima Ima Arum Lestarini Irwansyah, Andi Cakra Johansyah, Lydia Christina Makbul, Hidayat Ramadhita, Nova Izza Salsa Restuningdyah, Novia Andansari Putri Riskiana Djamin Syahrijuita, Syahrijuita