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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Neurona Acta Neurologica Indonesia
Yunus, Reyhan Eddy
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health

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RANGKAIAN KASUS CEDERA OTAK PENETRASI: PATOMEKANISME, IMPLIKASI KLINIS, DAN PENATALAKSANAAN DENGAN SUMBER DAYA TERBATAS Andini, Putri; Yugo, Mohammad Reynalzi; Yunus, Reyhan Eddy; Prawiroharjo, Pukovisa
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.396

Abstract

Penetrating brain injury differs markedly from blunt injury in dural tears and the transmission of kinetic energy to the surrounding structures along the penetrating tract. Unique clinical characteristics of penetrating brain injury (PBI) certainly require a case-by-case approach, however there are some principles that can be applied in almost every case and need to be considered to improve the outcomes. We present three cases of PBI with different mechanisms and outcomes. Two of the cases presented with non-missile PBI, while the third case presented with missile PBI. We also present a review of current literature highlighting various pathomechanisms, clinical implications and key approaches in managing PBI, particularly in resource-limited settings.
Association Between Brain Atrophy with EDSS and Number of Lesion Sites in Indonesian Multiple Sclerosis Patients Estiasari, Riwanti; Firdausia, Salsabila; Mulyadi, Rahmad; Yunus, Reyhan Eddy; Maharani, Kartika; Imran, Darma
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.17

Abstract

Introduction : Multiple sclerosis (MS) is a potentially disabling inflammatory demyelination of the central nervous system. The demyelination process will end up with the destruction of neurons that leads to the decrease of brain volume. Brain atrophy may cause more severe disability and affect the quality of life of MS patients, who are mostly at a young age. Objective : Our study aims to assess the brain atrophy among Indonesian MS patients and the association between with the degree of disability. Material and methods : A cross-sectional study included 28 MS patients. To determine the brain atrophy, we compared 11 healthy control group to the MS group. Head MRI was performed using 1.5T MRI and the brain volume was processed with Freesurfer type 6.0 automatic software. Result : The white matter (WM) and gray matter (GM) volume of MS patients was significantly lower compared to normal control with 78.6% GM atrophy and 67.9% WM atrophy. EDSS score is significantly associated with WM atrophy but not with GM atrophy. Factors related to WM atrophy is age, age of onset, and subtype of MS. A number of lesion sites were found greater in subjects with GM and WM atrophy. Discussion : The mechanisms of brain atrophy in MS involve inflammatory processes and neurodegeneration. Various factors, including lesion volume impact atrophy rates. Brain atrophy had correlation with EDSS scores. Conclusion : Brain atrophy was common in MS patients and significantly associated with the level of disability and number of lesion sites.
Rekomendasi Sistem Stroke Pendekatan 8D dalam Penanganan Stroke Iskemik Akut Permana, Affan Priyambodo; Nafisah, Zharifah Fauziyyah; Mesiano, Taufik; Yunus, Reyhan Eddy; Sulistio, Septo; Habib, Hadiki; Mulyana, Radi Muharris; Albar, Imamul Aziz
Majalah Kedokteran Indonesia Vol 71 No 1 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.1-2021-162

Abstract

Stroke is the leading cause of death in Indonesia and leading cause of long-termdisability in the world. Ischemic stroke include 85% of all stroke cases. Ischemic stroke is caused by thromboembolic blockage or arterial stenotic by atherosclerotic plaque. Current practice shows that ischemic stroke can be treated. Treatment using intravenous thrombolytic (IV-tPA) and mechanical thrombectomy will provide better outcomes for the patient. It can be achieved when treated kurang dari 4.5 hours since onset for IV-tPA and kurang dari 6-24 hours for large vessel occlusions using mechanical thrombectomy. However, only a small number of patients can achieve this treatment due to lack of society knowledge about the sign and symptoms, transportation problems, and the stroke management system that has not been well established. Every one minute stroke patient is left untreated, 1.9 millions neurons in the brain are dead. An integrated management of the stroke system can provide better outcomes, lower the length-of-stay of the patients in hospital and reduce the cost spent for treatment. One system that is recommended for managing stroke cases is 8D that consist of detection, dispatch, delivery, door, data, decision, drug/device, and disposition. This system will help health care providers to collaborate through a multidisciplinary system for managing acute ischemic stroke cases comprehensively so that stroke patients can get proper handling and better outcomes.
Co-Authors Albar, Imamul Aziz Firdausia, Salsabila Hadiki Habib, Hadiki Imran, Darma Maharani, Kartika Mesiano, Taufik Mulyana, Radi Muharris Nafisah, Zharifah Fauziyyah Permana, Affan Priyambodo Pukovisa Prawiroharjo, Pukovisa Putri Andini, Putri Rahmad Mulyadi, Rahmad Riwanti Estiasari Sulistio, Septo Yugo, Mohammad Reynalzi