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All Journal Jurnal Teknik Industri Terintegrasi (JUTIN) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of The Indonesian Society of Integrated Chemistry
Bela, Anisa
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Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Energy Engineering Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology

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In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
ANALISIS LC-MS/MS SENYAWA METABOLITE EKSTRAK DAUN PUTAT (Planchonia valida) DAN PREDIKSI POTENSINYA SEBAGAI KANDIDAT OBAT ANTIKANKER Dewi, Tribuana Tungga; Bela, Anisa; Prabawa, Satria; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1629

Abstract

Secondary metabolite compounds contained in plants are bioactive substances related to the chemical content in plants, so that some plants can be used as medicinal materials. Putat (Planchonia valida) is a medicinal plant that has bioactive compounds that have potential as anticancer. Compound analysis of LC-MS test results has been carried out which shows several metabolite compounds contained in putat. The method used is analyzing compounds obtained from LC-MS results, screening compounds using pchembl and chemspider websites. And using the pChEMBL webserver to find out the bioactivity of these compounds. The purpose of this study is to determine and predict the potential bioactivity of the compounds contained therein as new drug candidates. The results obtained from this study are metabolite compounds in putat have the potential as anticancer based on the screening results carried out using the pChEMBL webserver by looking at the highest pIC50 value, obtained the highest pIC50 value of 8.18 with target proteins namely Serine/threonin mTOR and Cholinesterase which are target proteins that have anticancer activity.
Penerapan Metode Six Sigma pada Proses Produksi Injection Molding Tipe X di PT. ABC Bela, Anisa; Ratnasari, Lisa
Jurnal Teknik Industri Terintegrasi (JUTIN) Vol. 7 No. 3 (2024): July
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jutin.v7i3.27621

Abstract

Masterpen is one of the types of ballpoint pens that experiences stable demand every month, necessitating consistent production quality to meet predetermined standards. In its production process, PT Zebra Asaba Industries involves several departments, one of which is the injection department. During the production process in the injection department, the components of Masterpen, specifically the lower stick of Masterpen, often suffer from product defects. Observations have revealed a 16% defect rate in the production output, comprising 61% flash defects, 23% silver defects, and 16%barrel defects. This research aims to delve into the underlying factors causing defects in the Red Masterpen Lower Stick product at PT Zebra Asaba Industries. The research employs the Six Sigma method. The results show that the DPMO (Defects Per Million Opportunities) value for flash defects is 47,885.57 with a Sigma level of 3.17, while for silver defects, the DPMO value is 18,034.83 with a Sigma level of 3.59.
Co-Authors Alfi Khatib, Alfi Dewi, Tribuana Tungga Faizar Farid Indra Lasmana Tarigan Lisa Ratnasari Madyawati Latief Nelson Prabawa, Satria Yusnaidar, Yusnaidar