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All Journal Indonesian Food Science and TechnologyJournal Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry
Alfi Khatib, Alfi
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Malaysia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering

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In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
LC-MS Based Metabolite Profiling of Ethanol Extract From the Sungkai (Peronema canescens Jack) and In Silico Prediction of Antidiabetic Activity With α-Glucosidase Latief, Madyawati; Arum, Dewi; Nurjannah, Sofia; Tarigan, Indra Lasmana; Khatib, Alfi; Yusnaidar, Yusnaidar
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.8806

Abstract

Sungkai (Peronema canescens Jack) is a medicinal plant in the Verbenaceae family that is known to have antidiabetic activity. The secondary metabolite content found in sungkai leaves is in the form of alkaloids, flavonoids, triterpenoids, steroids, phenolics, and saponins. This research aimed to identify the biological activity of compounds in sungkai plants as antidiabetic agents using α-glucosidase inhibitors in silico. Sungkai leaf extract with ethanol solvent was identified using a Liquid Chromatography Mass Spectrometer (LC-MS/MS). There are 15 compounds resulting from LC-MS/MS analysis which will then predict antidiabetic activity using molecular docking. Molecular docking was carried out using AutoDock Tools software and visualized with Discovery Studio. The highest scoring result obtained from the molecular docking test was the compound C13H23N6S with a free bond energy result of -7.31 and an inhibition constant value of 4.41 μM, which binds three hydrogen bonds in GLU 78, ALA 75, and GLU 198. Keywords: In sillico, metabolite profilling, Peronema canescens
Antioxidant Activity of Premna serratifolia Linn. Leaf Extracts: A Comprehensive Analysis Using Various Testing Methods Muhaimin, Muhaimin; Iskandar, Yoppi; Hazrina, Aghnia; Hirzan, Rifanza; Khatib, Alfi; Syahri, Wilda
Indonesian Food Science and Technology Journal Vol. 8 No. 1 (2024): Volume 8. Number 1, December 2024 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i1.37292

Abstract

Premna serratifolia Linn leaf possesses medicinal properties, useful in the treatment of cardiovascular diseases, skin diseases, inflammatory diseases, arthritis, rheumatism, anorexia, jaundice, intestinal worms, bad breath, lung infections, febrifuge, hypolipidemic, antioxidants, antidiabetic, CNS depressant and thalasemia treatment, among other things. The purpose of this study was to investigate the antioxidant effect of P. serratifolia Linn leaf from Indonesia. The leaves of P. serratifolia Linn were extracted with 95% ethanol and fractionated with n-hexane and ethyl acetate. The antioxidant activity was evaluated by various antioxidant assays, including  1-diphenyl-2-picrylhydrazyl (DPPH), 2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), nitric oxide scavenging and reducing power ability method. The extracts and fractions contained phytoconstituents such as alkaloid, flavonoid, phenolic, tanin, saponin, and steroid compounds, according to phytochemical analysis. The antioxidant activities were compared to standard antioxidant ascorbic acid. P. serratifolia Linn ethanol leaves extract showed a significant antioxidant activity in DPPH, ABTS, reducing power and nitric oxide scavenging methods compared others. The findings of the present study suggest that P. serratifolia Linn could be a potential source of natural antioxidant that could have greater importance as therapeutic agent in preventing or slowing oxidative stress related degenerative diseases.
Standardization of Moringa oleifera leaf powder extracts from different leaf stalk colors as raw material for herbal pharmaceuticals Fidyasari, Ambar; Estiasih, Teti; Wulan, Siti Narsito; Khatib, Alfi
Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Vol 8, No 3 (2025)
Publisher : Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.afssaae.2025.008.03.4

Abstract

Standardization in the pharmaceutical field is essential to ensure quality, and to meet chemical, biological, and pharmaceutical standards, including stability assurance as a pharmaceutical product. Specific and non-specific standardizations are conducted to guarantee the efficacy and quality of extracts, which ultimately ensure the pharmacological effects of the plant. This study aims to determine the specific and non-specific standardization parameters of ethanol extracts from green, white, and red Moringa oleifera leaf powder (MOLP). The highest extract yield was obtained from the red-stalked MOLP. The organoleptic analysis of the Moringa leaf extracts from various varieties resulted in thick extracts with a greenish-brown color, characteristic odor, and bitter taste. In the specific parameters, the water-soluble and ethanol-soluble extract contents met the standard of ≥ 5.0%. The non-specific parameters, including loss on drying, total ash content, acid-insoluble ash content, and extract specific gravity, all met the required standards. The total microbial contamination in the extracts met the criteria, remaining below the maximum limit of 10 colonies per gram. The chromatographic profile of the MOLP ethanol extracts obtained by Gas Chromatography-Mass Spectrometry (GC-MS) revealed the presence of terpenoids and steroids. The ethanol extract of MOLP complied with the content standards set by the Indonesian Pharmacopoeia.
Co-Authors Ambar Fidyasari Arum, Dewi Bela, Anisa Dewi, Tribuana Tungga Faizar Farid Hazrina, Aghnia Hirzan, Rifanza Indra Lasmana Tarigan Madyawati Latief Muhaimin Muhaimin Nelson Nurjannah, Sofia Prabawa, Satria Siti Narsito Wulan Teti Estiasih Wilda Syahri Yoppi Iskandar Yusnaidar, Yusnaidar