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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of The Indonesian Society of Integrated Chemistry Indonesian Scholar Journal of Nursing and Midwifery Science
Prabawa, Satria
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Chemical Engineering, Chemistry & Bioengineering Chemistry Education Medicine & Pharmacology Nursing

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In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
ANALISIS LC-MS/MS SENYAWA METABOLITE EKSTRAK DAUN PUTAT (Planchonia valida) DAN PREDIKSI POTENSINYA SEBAGAI KANDIDAT OBAT ANTIKANKER Dewi, Tribuana Tungga; Bela, Anisa; Prabawa, Satria; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1629

Abstract

Secondary metabolite compounds contained in plants are bioactive substances related to the chemical content in plants, so that some plants can be used as medicinal materials. Putat (Planchonia valida) is a medicinal plant that has bioactive compounds that have potential as anticancer. Compound analysis of LC-MS test results has been carried out which shows several metabolite compounds contained in putat. The method used is analyzing compounds obtained from LC-MS results, screening compounds using pchembl and chemspider websites. And using the pChEMBL webserver to find out the bioactivity of these compounds. The purpose of this study is to determine and predict the potential bioactivity of the compounds contained therein as new drug candidates. The results obtained from this study are metabolite compounds in putat have the potential as anticancer based on the screening results carried out using the pChEMBL webserver by looking at the highest pIC50 value, obtained the highest pIC50 value of 8.18 with target proteins namely Serine/threonin mTOR and Cholinesterase which are target proteins that have anticancer activity.
Hubungan Antara Layanan Keperawatan Dengan Tingkat Kepuasan Pasien Di Klinik Pratama Badan Pusat Statistik: The Relationship Between Nursing Services and the Level of Patient Satisfaction at the Pratama Clinic Central Agency for Statistics Prabawa, Satria
Indonesian Scholar Journal of Nursing and Midwifery Science Vol. 4 No. 06 (2025): Vol. 4 No. 06 (2025): Vol. 4 No. 06 (2025): Indonesian Scholar Journal of Nurs
Publisher : Dohara POAJ

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54402/isjnms.v4i06.527

Abstract

Introduction: A nursing service is said to be good if it fulfills patient needs according to standards, and good service will create a level of patient satisfaction according to standards. There are 5 factors that influence patient satisfaction, namely responsiveness, reliability, assurance, empathy and physical evidence. With these factors, patients can assess the nursing care they receive and can perceive whether it is in accordance with what the patient wants or not.   Method: The data scale for this research is an ordinal scale and uses a scatter statistical test. Spearman Rho is one of the non-parametric associative bivariate tests. This means that a non-parametric test is used to see the strength of the relationship between two variables that have an ordinal measurement scale. Results: The research results showed that the Spearman statistical test results for the Nursing Service and Satisfaction variables had a degree of significance of p (0,001) which means that the statistical test results showed p < 0,05; so H1 was accepted and meant there was a relationship between the two variables. Judging from the results of the Correlation Coefficient or how strong the relationship between two variables with the result of 0,744 which means it is very strong. Discussion: There is a relationship between nursing services and the level of patient satisfaction at the Pratama Clinic of the Central Bureau of Statistics.
Co-Authors Alfi Khatib, Alfi Bela, Anisa Dewi, Tribuana Tungga Faizar Farid Indra Lasmana Tarigan Madyawati Latief Nelson Yusnaidar, Yusnaidar