Claim Missing Document
Check
Articles

Found 2 Documents
Search

Expression of Immunoglobulin M (IgM) and Immunoglobulin G (IgG) in Normal Wistar Rat Post-Cheral® Administration Asyhari, Firda Nuri; Zulfatim, Heni Sukma; Putri, Nenis Try Melani; Dliyauddin, Moh; Jamil, Ahmad Shobrun; Soewondo, Aris; Natsir, Muhammad Halim; Ibrahim, Mansur; Rahayu, Sri; Djati, Muhammad Sasmito; Rifa’i, Muhaimin
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.1030-1036

Abstract

Maintaining immunoglobulin levels in the body is important to protect the body from exposure to pathogens. One effort can be made by consuming herbs containing immunomodulatory compounds, such as Cheral®, which includes a combination of herbs Phyllanthus niruri and Curcuma longa. This research aims to determine the expression of immunoglobulin M (IgM) and immunoglobulin G (IgG) following the administration of Cheral® to Wistar rats. The study was conducted in vivo, utilizing 24 healthy male Wistar rats for a 90-day treatment period. The research was divided into four treatment groups, including a control group and three dosage groups: Dose 1 (156.25 mg/kg BW), Dose 2 (312.5 mg/kg BW), and Dose 3 (468.75 mg/kg BW). IgM and IgG were isolated from the spleen and analyzed using flow cytometry. Flow cytometry data were analyzed using SPSS with a one-way ANOVA and post hoc test (p-value <0.05). The analysis showed that the relative number of IgM-producing cells in the control group was significantly higher than in the treatment groups, with a difference of 44.40%. In contrast, the relative number of IgG-producing cells in Dose 3 was significantly lower than all other treatment groups, showing a decrease of 29.21%. Overall, the expression of IgG and IgM did not differ substantially across all treatments. The lower IgG and IgM profiles compared to the control group indicate Cheral®'s ability to prevent infections and maintain the immune system of the rats throughout the treatment period.
Ethnobotany of Adenium obesum (Forssk.) Roem. &Schult. : A Review Setiyanto, Afif Eka Rahma; Zulfatim, Heni Sukma; Septi Tri Puspita Sari; Krisnawati, Dewi
Biotropika: Journal of Tropical Biology Vol. 12 No. 2 (2024)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2024.012.02.04

Abstract

Adenium obesum (Forssk.) Roem. & Schult., commonly known as the ‘desert rose,’ is a member of the Apocynaceae family, cultivated extensively in various tropical regions. While Adenium obesum is primarily used as an ornamental plant, previous research has documented its biological activities and phytochemical constituents. However, there has been no comprehensive review of its ethnobotanical applications. This study aims to summarize and discuss the ethnobotanical uses of Adenium obesum through a literature review. The ethnobotanical information of Adenium obesum can be categorized into five primary groups: ornamental plant, eco-print source, religious ceremonies, medicinal uses, and toxic effects. The plant is renowned for its aesthetic appeal, particularly its flowers and roots, often shaped into bonsai. This characteristic underscores its potential in the floriculture industry and agrotourism. In eco-printing, Adenium obesum creates patterns on fabrics through direct contact. In religious contexts, the plant is used in offerings and pilgrimage ceremonies at cemeteries. Adenium obesum has been approved for treating various diseases in humans and chickens. Conversely, it also possesses toxic properties that are harnessed for hunting purposes. Different regions and cultures employ Adenium obesum in diverse ethnobotanical applications. The findings conclude that Adenium obesum has significant ethnobotanical utility, presenting several prospects, such as its incorporation into the ornamental plant industry, agrotourism, and the development of other art objects or plant parts beyond its flowers. Furthermore, scientific validation is necessary to maximize the beneficial effects and manage the toxic properties of this plant to ensure its proper utilization.