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All Journal Jurnal Ilmu Dasar Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Wiyata : Penelitian Sains dan Kesehatan Bioscientist : Jurnal Ilmiah Biologi Pharmaqueous JURNAL PENGABDIAN PENDIDIKAN MASYARAKAT (JPPM) Biocaster : Jurnal Kajian Biologi JURNAL INSAN CENDEKIA
Fathul Hidayatul Hasanah, Fathul Hidayatul
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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KORELASI JUMLAH SEL MONOSIT DENGAN KADAR KOLESTEROL TOTAL PADA PASIEN HIPERKOLESTEROLEMIA DI RUMAH SAKIT X KOTA KEDIRI Hasanah, Fathul Hidayatul
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 3, No 1 (2016)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.557 KB)

Abstract

Latar Belakang: Hiperkolesterolemia dapat meningkatkan sekresi sitokin proinflamasi dan stress oksidatif yang dapat mengaktivasi sel monosit sebagai respon proinflamasi. Sitokin proinflamasi dan stress oksidatif, diduga merupakan penyebab primer sindrom metabolik. Tujuan: Penelitian ini bertujuan membuktikan adanya korelasi jumlah monosit dengan kadar kolesterol total pada pasien hiperkolesterolemia. Metode: Desain penelitian adalah studi cross-sectional dengan teknik sampling secara Purposive. Pasien hiperkolesterolemia dirawat di RSUD Kediri dengan kadar kolesteril >200 mg/dk dan rentang leukosit 4-10 x 103 sel/ml Hasil: Berdasarkan hasil uji korelasi pearson menunjukkan bahwa terdapat korelasi antara jumlah monosit dengan kadar kolesterol total dengan nilai p = 0.038(<0.05), berkorelasi positif dengan tingkat korelasi sedang yang ditunjukkan oleh nilai r = 0.380, dengan jumlah monosit 0.48 103 sel /μl. Simpulan dan saran: Ada korelasi antara kadar kolesterol total dengan jumlah sel monosit pada pasien hiperkolesterolemia, peningkatan kadar kolesterol total akan meningkatan jumlah monosit. Penelitian selanjutnya perlu memperhatikan C-Reactive Protein sebagai penanda adanya infeksi dalam inklusi
KORELASI NEUTROPHIL LYMPHOCYTE RATIO (NLR), SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGOT) DAN SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGPT) PADA PASIEN COVID-19 SEBAGAI INDIKATOR INFLAMASI ORGAN HATI Fathul Hidayatul Hasanah; Sri Wahyuni; Fita Sari
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 9, No 1 (2022)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v9i1.596

Abstract

Latar belakang: Aktivitas enzim hati Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT) akan meningkat ketika terjadi infeksi. Tujuan: untuk mengetahui korelasi NLR  terhadap SGOT dan SGPT pada Pasien Covid-19 Sebagai Indikator Inflamasi Organ Hati. Metode: Desain penelitian menggunakan Study cross sectional dan tehnik sampling accidental. Responden berjumlah 38 pasien Covid-19 di rumah sakit Umum Daerah Nganjuk dengan kriteria inklusi pasien Covid-19 tidak memiliki riwayat penyakit liver dan kriteria ekslusi adalah pasien covid 19 dengan penyakit infeksi lain (Tuberculosis, Tipoid, demam dengue) dan penyakit autoimun. Hasil: Diperoleh nilai rata-rata NLR 7,0 >3,13 dengan 74% meningkat,Kadar rata-rata SGPT 58,5 UI dan 61% mengalami peningkatan, sedang rata-rata SGPT 46,7 UI dan 76% berada di rentang normal. Berdasarkan uji perason nilai NLR terhadap SGOT ( sig = 0,629 > 0,05 dan r = 0,081) dan  NLR terhadap SGPT (sig = 0,575 >0,05 dan r= 0,094). Simpulan: tidak ada korelasi antara NLR terhadap SGOT dan SGPT pada pasien Covid-19
The Education of Home Herbal Utilization As Healthy Drink for Virus Antidote Fita Sari; Fathul Hidayatul Hasanah; Farida Noor; Rosa Juwita Hesturini
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 9, No 2 (2023): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.69704

Abstract

The herbal drink in Indonesia has a fast development for its easy usage and minimum side effect. Some house plants have metabolite compounds with an important role as antiviral such as rosella (Hibiscus sabdariffa), Curcuma domestica Val, Zingiber officinale, Cymbopogon citratus, and Pandanus amaryllifolius R. The purpose of our community empowerment activities was to introduce the benefits of house plants for supporting health, particularly as an antiviral during a pandemic. The method of community empowerment activities was carried out by explaining the example of home plants, their bioactive compound content, and their health benefits. The community was also taught to make simple and practical healthy drinks. The results showed that the community became more aware of the benefits of roselle and turmeric so that they did not doubt making a healthy drink to be consumed regularly during the pandemic. The results showed that about 85% of the community understood the benefits, and 90% were able to make herbal drinks. The conclusions of these community empowerment activities were going well. The community understood the benefits of house plants as an antiviral during a pandemic and succeeded in making simple healthy drinks from house plants.
The Expression of The PfEMP1-DBL2β Recombinant Protein of Plasmodium falciparum Isolated From Indonesia Hasanah, Fathul Hidayatul; Sulistyaningsih, Erma; Sawitri, Widhi Dyah
Jurnal ILMU DASAR Vol 21 No 1 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.49 KB) | DOI: 10.19184/jid.v21i1.10494

Abstract

The binding of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) to Intracellular Adhesion Molecule-1 (ICAM-1) is a major pathological mechanism in severe malaria including cerebral malaria. The binding is mediated by PfEMP1-DBL2β domain. The study aimed to explore there combinant protein of PfEMP1-DBL2β domain of P. falciparum isolated from Indonesia. DNA was isolated from a severe malaria patient. The DBL2β domain was amplified using Polymerase Chain Reaction (PCR) with specific primer and cloned into the pJET1 cloning vector. The DBL2β recombinant protein was constructed from DBL2β-pJET1 clone using pET-30a expression vector and expressed in Escherichia coli BL21-DE3. PCR colony and digestion of plasmid clones using restriction enzymes were conducted to confirm cloning result, and the expression of recombinant protein was analyzed using Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE). The expression of DBL2β-PfEMP1 domain is higher in pellet than in supernatant fraction. In conclusion, the DBL2β-PfEMP1 domain recombinant protein of P. falciparum isolated from Indonesia expressed as a ~66 kDa protein in full length. Keywords: DBL2β domain, Indonesia, PfEMP1, Plasmodium falciparum, recombinant protein.
PIRING MAKAN KU “MAKAN SEHAT UNTUK TUMBUH KEMBANG ANAK” Wahyuni, Ismiy; Sabban, Indra Fauzi; Wardani, Siska Kusuma; Hermawan, Rizal Aditya; Hasanah, Fathul Hidayatul; Wahyuni, Sri; Rokim, Moch. Abdul; Setiawan, Jessi Suryani
Jurnal Pengabdian Pendidikan Masyarakat (JPPM) Vol 5 No 2 (2024): Jurnal Pengabdian Pendidikan Masyarakat (JPPM), Vol 5 No 2 (2024)
Publisher : LPPM UNIVERSITAS MUHAMMADIYAH MUARA BUNGO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52060/jppm.v5i2.2329

Abstract

It is hoped that the healthy eating pattern approach will not be carried out with angry or violent actions but rather with a good approach so that children can enjoy eating and support their growth and development. An approach that can be taken to encourage children to consume healthy food is introducing various types of food and their contents as a basis for children's knowledge. With this knowledge, children can assess whether the food content on their dinner plate includes four healthy, five perfect, or not. Based on this, it is important to carry out Community Service (PkM) activities targeting elementary school students at SDN Karanganyar Village, Wates District, Kediri Regency. This PkM activity aims to invite students to become familiar with the contents of foods that are often found in the daily diet as an effort to maintain a healthy diet for children's growth and development. Based on the observations and evaluations, the students were enthusiastic when receiving material about "My Dinner Plate" and guessing the nutritional content of various foods. The results of the T-test show a value of 0.001, which means there is a significant difference between the pre-test and post-test scores and there is an increase in students' knowledge of 70%.
Korelasi hs-CRP dan Keberadaan Staphylococcus aureus pada Luka Gangren Diabetes Mellitus Tipe II Sri Wahyuni; Fathul Hidayatul Hasanah; Binti Mu’arofah; Verdyan Taufan Rizky Jeferson
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.11796

Abstract

Diabetes mellitus (DM) is a metabolic disorder that is accompanied  by an increased glucose in the blood or called hyperglycemia. Diabetes can be caused by problems with the pancreas not being able to produce insulin, insufficient insulin secretion, imperfect insulin action, or both. When blood glucose is left elevated for a long time, it can cause complications such as gangrene. Diabetic gangrene is one of the complications caused by tissue damage. Gangrene occurs due to neuropathy and vascular disorders, usually in the peripheral areas of the body. Bacteria found in diabetic wounds are bacteria that produce biofilms such as Staphylococcus aureus. Staphylococcus aureus can release exotoxins such as leukocidin. Leucosidine lyses PMNs and releases ROS which will then induce a cytokine response such as interleukin-6 which will increase CRP levels. hs-CRP is a high precision CRP measurement even at low concentrations.This study aims to determine the correlation between hs-CRP levels and the presence of Staphylococcus aureus in type II diabetes mellitus gangrene wounds. The research design used is observational analytical using a cross sectional approach and accidental sampling. There were 16 research respondents with increased hs-CRP levels in 15 respondents and 9 respondents with Staphylococcus aureus bacteria. Correlation test with a value of p = <0.05 (p=0.032) means that there is a correlation between hs-CRP and the presence of Staphylococcus aureus in type II diabetes mellitus gangrene wounds.
KOLERASI GLUKOSA DARAH DENGAN HS-CRP PADA PASIEN DIABETES MELITUS TIPE 2 Sri Wahyuni; Fathul Hidayatul Hasanah; Agnes Eka Lusiana
Jurnal Insan Cendekia Vol 10 No 2 (2023): Jurnal Insan Cendekia
Publisher : STIKES Insan Cendekia Medika Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35874/jic.v10i2.1139

Abstract

Pendahuluan: Diabetes mellitus (DM) merupakan penyakit ganguan metabolic yang ditandai dengan meningkatkannya glukosa darah. DM tipe 2 yaitu tipe dari diabetes karena peningkatan glukosa darah menyebabkan penurunan sekresi insulin oleh sel beta pancreas atau resistensi insulin. High Sensitivity C-Reactive Protein (hs-CRP) petanda inflamasi berkaitan dengan DM tipe 2 dan peningkatan risiko kardiovaskuler. Tujuan: untuk mengetahui kolerasi Glukosa darah dengan hs-CRP pada Pasien Diabetes Melitus tipe 2. Metode: Desain penelitian menggunakan analitik observasional dengan menggunakan Study cross sectional dan tehnik sampling purposive sampling. Respoden berjumlah 30 pasien DM tipe 2 di Rumah Sakit Kristen Mojowarno. Hasil: Diperoleh nilai rata-rata glukosa darah 255,6 mg/dL dan hs-CRP 2,5 mg/dL. Berdasarkan uji Sperman rho glukosa darah dengan hs-CRP (sig = 0,163 > 0,05 dan r= 0,262). Kesimpulan : tidak terdapat kolerasi antara gukosa darah dengan kadar Hs-CRP pada Pasien Diabetes Melitus tipe 2
Analisis Korelasi Neutrophil-Lymphocyte Ratio (NLR) dengan Indikator Komplikasi Makrovaskular dan Mikrovaskular pada Diabetes Melitus Tipe 2 Hasanah, Fathul Hidayatul; Wahyuni, Sri; Primartati, Danny Meganingdyah; Fatmariza, Aulia Risqi; Sari, Fita
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.501

Abstract

Type 2 Diabetes Mellitus (DM type 2) is associated with low-grade systemic inflammation. Neutrophil-Lymphocyte Ratio (NLR) is a pro-inflammatory and oxidative stress biomarker in cardiometabolic diseases such as T2DM. This study aims to analyze the relationship of NLR with leukocyte count, random blood glucose, creatinine, total cholesterol, Serum Glutamic Pyruvic Transaminase (SGPT), and Serum Glutamic Oxaloacetic Transaminase (SGOT). The study design is a retrospective analysis with respondents of 162 uncomplicated T2DM patients treated at Mojowarno Christian General Hospital, Jombang. The results of the study showed that the average number of leukocytes was 12,688 cells/µl, neutrophils 75.3%, lymphocytes 17.2%, NLR 8.5, blood glucose 273.2 mg/dl, SGOT 40.88 U/l, SGPT 54.64 U/l, total cholesterol 196.3 mg/dl (<200), and creatinine 1.13 mg/dl. Correlation tests showed that NLR was significantly associated with leukocyte count (p = 0.000 < 0.05) and total cholesterol (p = 0.000 < 0.05), but not significantly correlated with random blood glucose (p = 0.064 > 0.05), SGOT (p = 0.089 > 0.05), SGPT (p = 0.929 > 0.05), or creatinine (p = 0.625 > 0.05). In conclusion, in patients with type 2 diabetes, NLR was significantly correlated with leukocyte count and total cholesterol, but not with random blood glucose, SGOT, SGPT, or creatinine.
Gambaran Limfosit Pasca Vaksin Covid-19 Booster Wahyuni, Sri; Hasanah, Fathul Hidayatul
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 5 No. 2 (2023): Volume 5, Nomor 2, November 2023
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v5i2.316

Abstract

COVID-19 merupakan penyakit yang disebabkan oleh virus SARS-CoV-2. Pada maret tahun 2020 WHO mengumumkan menjadi wabah global di dunia. Negara di dunia menanggapi wabah tersebut dengan berbagai respon. Banyak negara yang membatasi masuk dan keluar antar negara dan kebijakan- kebijakan darurat yang dibuat disetiap negara. Pemerintah Indonesia merespon kejadian tersebut dengan berbagai kebijakan. Penerapan protokol kesehatan, pemberlakuan kebijakan Pembatasan Sosial Berskala Besar (PSBB), serta kebijakan lainya. Pemerintah juga menggalakkan vaksin covid-19 untuk mengecegah penularan, mengurangi resiko sakit dan menurunkan angka kematian akibat covid-19. Vaksin merupakan produk biologi yang berfungsi membentuk antibodi spesifik terhadap penyakit tertentu. Vaksin covid-19 yang digalakkan pemerintah ada vaksin covid-19 tahap 1, tahap 2 , tahap 3 (booster). Vaksin tahap 1 dan 2 diharapkan membentuk antibody spesifik terhadap covid-19. Vaksin booster diharapkan mampu meregenerasi antibodi dan memperpanjang imunitas. Limfosit merupakan bagian dari leukosit agranulosit untuk membentuk antibody. Tujuan dari penelitian ini untuk mengetahui gambaran dari limfosit pasca vaksinasi covid-19 booster. Metode yang digunakan yaitu diskriptif dengan purposive sampling. Sampel penelitian yaitu mahasiswa IIK Bhakti wiyata Kediri yang sudah vaksin covid-19 booster yang memenuhi kriteria yang sudah ditetapkan peneliti. Sampel yang digunakan adalah darah dengan EDTA dan pemeriksaan limfosit pada penelitian ini mengunakan hematologi analyzer. Hasil penelitian dari 30 responden didapatkan limfosit menurun 2 responden, normal 22 responden, meningkat 6 responden. Nilai rata-rata kadar limfosit 28,39. Dapat disimpulkan bahwa gambaran limfosit pasca vaksinasi covid-19 ada yang menurun, normal dan meningkat. Terdapat beberapa hal yang bisa mempengaruhi kadar limposit.
Korelasi hs-CRP dan Keberadaan Staphylococcus aureus pada Luka Gangren Diabetes Mellitus Tipe II Wahyuni, Sri; Hasanah, Fathul Hidayatul; Mu’arofah, Binti; Jeferson, Verdyan Taufan Rizky
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.11796

Abstract

Diabetes mellitus (DM) is a metabolic disorder that is accompanied  by an increased glucose in the blood or called hyperglycemia. Diabetes can be caused by problems with the pancreas not being able to produce insulin, insufficient insulin secretion, imperfect insulin action, or both. When blood glucose is left elevated for a long time, it can cause complications such as gangrene. Diabetic gangrene is one of the complications caused by tissue damage. Gangrene occurs due to neuropathy and vascular disorders, usually in the peripheral areas of the body. Bacteria found in diabetic wounds are bacteria that produce biofilms such as Staphylococcus aureus. Staphylococcus aureus can release exotoxins such as leukocidin. Leucosidine lyses PMNs and releases ROS which will then induce a cytokine response such as interleukin-6 which will increase CRP levels. hs-CRP is a high precision CRP measurement even at low concentrations.This study aims to determine the correlation between hs-CRP levels and the presence of Staphylococcus aureus in type II diabetes mellitus gangrene wounds. The research design used is observational analytical using a cross sectional approach and accidental sampling. There were 16 research respondents with increased hs-CRP levels in 15 respondents and 9 respondents with Staphylococcus aureus bacteria. Correlation test with a value of p = <0.05 (p=0.032) means that there is a correlation between hs-CRP and the presence of Staphylococcus aureus in type II diabetes mellitus gangrene wounds.
Co-Authors Agnes Eka Lusiana Aulia Risqi Fatmariza Binti Mu’arofah Danny Meganingdyah Primartati Erma Sulistyaningsih Farida Noor Fita Sari, Fita Indra Fauzi Sabban Jeferson, Verdyan Taufan Rizky MOCH ABDUL ROKIM MU’AROFAH, Binti Rizal Aditya Hermawan Rosa Juwita Hesturini Sari, Fita Setiawan, Jessi Suryani Siska Kusuma Wardani, Siska Kusuma Sri Wahyuni Verdyan Taufan Rizky Jeferson Wahyuni, Ismiy Wahyuni, Sri Widhi Dyah Sawitri