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All Journal Pharmaciana: Jurnal Kefarmasian JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia
Nuari, Yudha Rizky
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Spray gel film-forming system formulation of Vernonia amygdalina as diabetic wound healer Novitasari, Putri Rachma; Nuari, Yudha Rizky; Firdausi, Azzahro Aulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1645

Abstract

Poorly managed diabetes mellitus may elevate the risk of having a diabetic wound that may lead to non-traumatic lower limb amputation. Therefore, wound healing management in diabetic patients is essential to prevent such complications. African leaves (Vernonia amygdalina) has been widely used for wound treatment empirically for years including diabetic wounds. The current study focuses on developing an African leaves-based spray using a film-forming system for diabetic wound healing. The African leaves extract is formulated with polyvinyl alcohol (PVA) to create a viscous liquid and is then made into a spray gel-film form. The spray gel film formulation was further characterized and tested for its wound closure efficacy in animal testing. The characterization include watery form, green colour and a characteristic odour of African leaf extract. The spray gel film preparation of Vernonia amygdalina 1;2;4% extract have pH of 5.92±0.0011; 5.96±0.0011 and 5.42±0.0011. The viscosity value of the spray gel film 1;2 and 4% were 7.98±0,0012; 8.43±0.0019 and 5.70±0.0013 cPs. Dry time of Spray Gel Film of Vernonia amygdalina 1;2;4% extract were 1.47±0.0013; 1.50±0.0010; and 1.56±0.0010 minutes. The wound healing was evaluated using diabetic Wistar rats by measuring daily wound diameter. The result showed at a concentration 1%; 2%; 4% the percentage diameter of wound healing were 81.52±±0.06; 82.28±±0.05; and 100±±0.00 %. They were effective for wound healer in diabetic rats and it had antibacterial activities.
Investigating the Impact of Surfactant and Cosolvent on the Polyphenolic Content in Arumanis Mango Leaf Extract (Mangifera indica L.) Fatimah, Siti Fatmawati; Farida, Verda; Nuari, Yudha Rizky; Viviandhari, Daniek; Pertiwi, Deasy Vanda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.39-47.2024

Abstract

The leaf of Mangifera indica L. contains flavonoids and mangiferin which showed positive effects on wound healing of diabetic ulcer. The used of suitable surfactant and co-solvent is required to ensure the high solubility of the active pharmaceutical ingredient (API), thereby optimizing the efficacy. This study aims to determine the ideal surfactant and cosolvent for a thermosensitive hydrogel formula of Mangifera indica leaf ethanol extract. The leaf was fextracted by maceration using 70% ethanol then determined for moisture content.  The extract was prepared for solubility tests of flavonoid and mangiferin on surfactants (Kolliphor® EL, Tween® 20, Tween® 80, Miranol® C2M) and co-solvents (Glycerin, PEG 400, and transcutol). Methods for total flavonoids content were Spectrophotometry UV-Vis and mangiferin with RP-HPLC method. The moisture content in the extract is 8.590 ± 0.754%. The surfactant demonstrating the highest capability in flavonoid dissolution is Tween 20 (1863.750 ± 0.838 µgQE/g extract), followed by Tween 80, Kolliphor EL, and Miranol C2M. In the context of co-solvents, PEG 400 (1309.583 ± 0.292 µgQE/g extract) show superior flavonoid dissolution capability, with glycerin and Transcutol following in descending order. Tween 20 and Tween 80 exhibite comparable efficacy in mangiferin dissolution, followed by Miranol C2M and Kolliphor EL. Among co-solvents, Transcutol demonstrate the highest aptitude for mangiferin dissolution, succeeded by PEG 400 and glycerin. This study indicates Tween 20 is a preferable surfactant and PEG 400 was considered as co-solvent to be further used in a thermosensitive gel formula for diabetic ulcer. 
Effects of Piper crocatum leaf extract-based ointments on bacteria associated with diabetic ulcers: an in vitro study Nuari, Yudha Rizky; Abusri, Mila; Yuntari, Wahyu; Tryadi, Oca Maharani; Ardhiana, Fiarriescha Marra
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28653

Abstract

Diabetic patients with poor blood glucose control are highly susceptible to developing secondary infections, which can lead to the development of prolonged diabetic ulcers. Therefore, a suitable medication that may effectively prevent the occurrence of secondary infections is crucial to shorten the closure of diabetic ulcers. Red betel leaf (Piper crocatum Ruiz & Pav) reportedly possesses antimicrobial activity due to the presence of flavonoids. This study aimed to evaluate the effect of ethanolic extract of red betel leaf (EERBL) ointments against the most prevalent bacteria associated with diabetic foot ulcers (DFU): Staphylococcus aureus and Pseudomonas aeruginosa. The EERBL was prepared by macerating powdered red betel leaf with 96% ethanol and was screened for the presence of flavonoids and the determination of total flavonoid content (TFC) by thin layer chromatography and UV-Vis spectrophotometry, respectively. This study examined three hydrophilic-based ointments containing 10%, 20%, and 30% EERBL, respectively, followed by characterization for pH, spreadability, stickiness, and viscosity. The EERBL ointments' effect on the bacteria was evaluated using the well-diffusion method by observing inhibition zone formation after 24-hour incubation. The results showed that varying the EERBL concentrations in the formulations led to different spreadability, stickiness and viscosity (p<0.05). Furthermore, all EERBL ointments demonstrated the formation of an inhibition zone on cultured media, indicating the presence of antimicrobial activity. The ointment with 30% EERBL had the largest diameter of the inhibition zone against both bacteria (p<0.05). The findings suggest enhanced antimicrobial activity was observed with an increase in the concentration of EERBL within the ointments.
Co-Authors Abusri, Mila Ardhiana, Fiarriescha Marra Firdausi, Azzahro Aulia Novitasari, Putri Rachma Pertiwi, Deasy Vanda Siti Fatmawati Fatimah, Siti Fatmawati Tryadi, Oca Maharani Verda Farida Viviandhari, Daniek Yuntari, Wahyu