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All Journal Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Abdi Masyarakat Indonesia Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Pribadi Wiranda Busro
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health

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Evaluation of myocardial injury from use of aortic cross-clamp and cardiopulmonary bypass duration in patients undergoing tetralogy of Fallot corrective surgery Wardoyo, Suprayitno; Djer, Mulyadi M.; Busro, Pribadi Wiranda
Paediatrica Indonesiana Vol. 65 No. 2 (2025): March 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.2.2025.147-55

Abstract

Background Much remains unknown about the myocardial injury caused by aortic cross-clamp and cardiopulmonary bypass durations in children undergoing open-heart surgery, especially children with cyanotic congenital heart disease. To assess this injury, specific biomarkers can provide valuable insights. Troponin I (TnI) is known to be a specific marker of heart damage, while serum lactate serves as an indicator of tissue hypoperfusion and ischemic events. Additionally, malondialdehyde (MDA) is recognized as a marker of oxidative stress resulting from CPB machine usage. Objective To investigate the association of aortic cross clamp and CPB durations on myocardial injury and oxidative stress in children undergoing TOF corrective surgery. Methods We conducted this prospective study which included 29 patients diagnosed with TOF and who underwent corrective surgery. Troponin I and MDA levels were measured before surgery, 1 hour after surgery, and 8 hours after surgery. Lactate levels were measured in arterial blood specimens taken before surgery, as well as 1 hour, 6 hours, 12 hours, and 24 hours after surgery. Results Twenty-nine patients were included in this study and divided into groups based on aortic cross-clamp duration: shorter (<38 minutes) or longer (≥38 minutes), as well as based on CPB duration: shorter (<75 minutes) or longer (≥75 minutes), according to the median. Wilcoxon test indicated For the <38 min clamp duration group, there was only a significant increase in TnI at 1 hour compared to pre-op (P=0.048). However, there were no significant different in TnI, MDA, or lactate levels at any time point between the two CPB or cross-clamp groups.
Peningkatan Literasi Kesehatan Kardiovaskular melalui Penyuluhan dan Pelatihan Bantuan Hidup Dasar di Yayasan Santri Peduli Negeri, Bekasi, Jawa Barat Busro, Pribadi Wiranda; Wardoyo, Suprayitno; Mety, Susan Hendriarini; Putra, Muhammad Hendra Ridanny; Satriadinatha, Gede Bagus Yoga; Sitanggang, Johan Samuel
Jurnal Abdi Masyarakat Indonesia Vol 6 No 1 (2026): JAMSI - Januari 2026
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.2336

Abstract

Penyakit kardiovaskular masih menjadi penyebab utama kematian di Indonesia. Rendahnya kesadaran masyarakat terhadap faktor risiko dan tindakan kegawatdaruratan menjadi tantangan besar dalam upaya pencegahan dan penanganan dini. Melalui kegiatan pengabdian masyarakat yang dilaksanakan di Yayasan Santri Peduli Negeri, Bekasi, tim Departemen Bedah Toraks, Kardiak, dan Vaskular FKUI berupaya menumbuhkan literasi kesehatan jantung serta keterampilan dasar penyelamatan nyawa melalui penyuluhan dan pelatihan Bantuan Hidup Dasar (BHD). Kegiatan yang diikuti oleh 52 peserta ini berlangsung interaktif dan partisipatif. Peserta tidak hanya mendapatkan pengetahuan mengenai penyebab dan tanda-tanda penyakit jantung, tetapi juga berlatih langsung melakukan tindakan pertolongan pertama pada henti jantung. Setelah mengikuti sesi edukasi dan pelatihan, sebagian besar peserta menunjukkan pemahaman yang lebih baik, terutama dalam mengenali tanda serangan jantung dan memahami pentingnya deteksi dini. Mereka juga merasa lebih percaya diri untuk bertindak jika menemukan keadaan gawat jantung di sekitar mereka. Kegiatan ini menunjukkan bahwa edukasi kesehatan yang dilakukan secara langsung di tengah masyarakat dapat memberikan dampak nyata. Selain meningkatkan pengetahuan, program ini menumbuhkan sikap peduli dan kesiapsiagaan masyarakat terhadap masalah kesehatan jantung. Upaya seperti ini diharapkan dapat terus berlanjut sebagai bentuk pemberdayaan komunitas menuju masyarakat yang lebih sadar, tanggap, dan berdaya dalam menjaga kesehatan kardiovaskular.
Efektivitas Pemberian Deksametason dalam Memengaruhi Durasi Perawatan di Rumah Sakit Pada Operasi Bedah Pintas Arteri Koroner Off Pump Rally Galang Pratama Putra; Dudy Arman Hanafy; Dicky Aligheri Wartono; Pribadi Wiranda Busro; Bagus Herlambang
Majalah Kedokteran Indonesia Vol 71 No 6 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.6-2021-746

Abstract

Introduction: The off pump coronary artery bypass surgery (OPCAB) technique is expected to be able to eliminate the side effects and complications caused by the use of a cardiopulmonary bypass (CPB) machine. However, this technique is not completely free from side effects or complications. One of the effects that can be caused is an increase in the systemic inflammatory response, so that the duration of hospitalization becomes longer. This is aim of this study to conduct a study of the administration of dexamethasone for reduced the length of hospital stay in patients undergoing OPCAB surgery. Methods: This was an analytic observational study with sixty patients who underwent OPCAB surgery and were randomized to either dexamethasone or placebo groups of 30 people each. Clinical results were analyzed. Results: The length of stay in the dexamethasone group compared to the placebo group was consecutive (5 (5-8) days vs 6.5 (5-30) days; p=0.04) so that there was a significant difference. Other clinical outcomes in the dexamethasone group were better than the placebo group, in terms of duration of mechanical ventilation (p=0.03) and intensive care unit stay (p=0.03). There were significant differences in inflammatory markers between the two groups: interleukin-6 (p=0.0001), procalcitonin (p=0.0001), and C-reactive protein (p=0.0001) were lower in the dexamethasone group. Conclusion: Preoperative dexamethasone in patients undergoing off-pump coronary artery bypass is effective in reducing the length of hospital stay and controlling postoperative inflammatory reactions.
The Effect of Colchicine on St. Thomas II Cardioplegia on Ischemia-Reperfusion Injury: A Histomorphological Study in Rabbits Rizky Aditya Fardhani; Pribadi Wiranda Busro; Sugisman Sugisman
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5677

Abstract

The maternal mortality rate in South Sumatra Province was recorded at 128 cases in 2020 and increased Cardioplegia is an important method for protecting the heart from ischemia-reperfusion (I/R) injury. However, myocardial damage from reperfusion can't be completely prevented by standard cardioplegia solutions alone. The St. Thomas II cardioplegia solution, with a lower potassium concentration, has been shown to have a cardioprotective effect, while colchicine, as an anti-inflammatory agent, works by inhibiting NLRP3 inflammasome activation and neutrophil modulation. This experimental study used a randomized controlled trial (RCT) post-test-only design on 12 New Zealand white rabbits, which were randomly divided into two groups: a control group (St. Thomas II) and a treatment group (St. Thomas II + colchicine). The primary outcome was the degree of myocardial histomorphological damage at 200× magnification. The results showed that five out of six samples from the control group had severe damage (score 3), while five out of six samples from the treatment group had no damage (score 0). A Mann-Whitney test yielded a p-value of 0.0152, indicating a significant difference. The addition of colchicine to St. Thomas II was shown to significantly reduce myocardial histomorphological damage. These findings suggest that colchicine could be considered as a cardioplegia adjuvant to enhance myocardial protection during cardiac surgery.
Co-Authors Bagus Herlambang Dicky Aligheri Wartono Hanafy, Dudy Arman Mety, Susan Hendriarini Mulyadi M. Djer Putra, Muhammad Hendra Ridanny Rally Galang Pratama Putra Rizky Aditya Fardhani Satriadinatha, Gede Bagus Yoga Sitanggang, Johan Samuel Sugisman Sugisman Wardoyo, Suprayitno