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All Journal Bioscientist : Jurnal Ilmiah Biologi Jurnal Ruaya : Jurnal Penelitian dan Kajian Ilmu Perikanan dan Kelautan
Insyira, Rania
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Social Sciences Veterinary

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Daya Hambat Ekstrak Kasar dan Fraksi Ekstrak Etanol Daun Gribong (Archidendron clypearia (Jack) I.C. Nielsen) Terhadap Bakteri Penyebab Jerawat Insyira, Rania; Lingga, Rahmad; Salmi, Salmi
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12480

Abstract

Acne is a dysbiotic condition caused by Cutibacterium acnes and Staphylococcus epidermidis bacteria. Gribong (Archidendron clypearia (Jack) I.C. Nielson) has been empirically used as a treatment for facial problems by the people of Bangka Belitung. This study aims to test the potential of ethanol extract and fractions of gribong leaves against two bacteria that cause acne. This study is an experimental research conducted in four stages, namely phytochemical testing, antibacterial activity testing, minimum inhibitory concentration testing, and minimum bactericidal concentration testing and equivalence tests against clindamycin antibiotics as positive controls. The results of this study showed (1) Secondary metabolites contained in 96% ethanol extract, ethyl acetate fraction and n-butanol fraction are phenolics, flavonoids, tannins and saponins. Terpenoids were only found in the ethanol extract. The ethyl acetate fraction found no alkaloids and the n-hexane fraction contained only steroids. (2) The 96% ethanol extract, ethyl acetate fraction and n-butanol fraction had antibacterial activity. (3) The highest antibacterial activity was shown by the ethyl acetate fraction with KHM on C. acnes at 0.375% and on S. epidermidis at 1% and KBM for both bacteria at 2.5%. (4) The equivalence value of antibacterial activity of fractions to antibacterial antibiotic clindamycin is still relatively low but still has good antibacterial activity. In conclusion, the ethanol extract and its fractions have potential as anti-acne against C. acnes and S. epidermidis bacteria.
Penghambatan Xantin Oksidase Oleh Gel Ekstrak Takokak (Solanum torvum Swartz) Berbasis Nanoteknologi Secara In Vitro Dwiyansyah, Muhammad Imam; Insyira, Rania; Mirsa, Almira Maurilla; Sawalia, Azzara Gita; Nugra, Daffa; Salmi, Salmi
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12610

Abstract

Inhibition of xanthine oxidase is one of the strategies in handling gout. This study aims to explore the potential of takokak fruit extract (Solanum torvum Swartz) in inhibiting nanotechnology-based xanthine oxidase in the form of nanoemulgel. This research is an experimental study conducted in several stages, namely qualitative phytochemical tests, quantitative identification of total flavonoid content and preparation of nanoemulgel made with 3.75% extract with variations of surfactant Tween 80 and PEG 400, namely F1 (30:30), F2 (35:25) and F3 (40:20). The ability of the extract and nanoemulgel was evaluated in inhibiting xanthine oxidase. The results showed that the ethanol extract of takokak fruit contained flavonoids, saponins, phenolics and tannins qualitatively. The total flavonoid content in the extract was 4.472 ± 0.133 mgQE. Formulation F2 has the smallest particle size (18.5 nm) and polydispersity index of 0.1313. Takokak fruit extract has almost the same inhibitory power as allupurinol with an IC50 value of 45.54 ppm. The IC50 value of nanoemulgel 3.75% takokak extract is 29.26 ppm so that the IC50 of the extract in nanoemulgel form is 1.10 ppm (45 times the IC50 of the crude extract). In conclusion, Formula F2 is the best formula in the preparation of nanoemulgel with particle size and polydispersion index and strong xanthin oxidase inhibitory activity.
Daya Hambat Ekstrak Kasar dan Fraksi Ekstrak Etanol Daun Gribong (Archidendron clypearia (Jack) I.C. Nielsen) Terhadap Bakteri Penyebab Jerawat Insyira, Rania; Lingga, Rahmad; Salmi, Salmi
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12480

Abstract

Acne is a dysbiotic condition caused by Cutibacterium acnes and Staphylococcus epidermidis bacteria. Gribong (Archidendron clypearia (Jack) I.C. Nielson) has been empirically used as a treatment for facial problems by the people of Bangka Belitung. This study aims to test the potential of ethanol extract and fractions of gribong leaves against two bacteria that cause acne. This study is an experimental research conducted in four stages, namely phytochemical testing, antibacterial activity testing, minimum inhibitory concentration testing, and minimum bactericidal concentration testing and equivalence tests against clindamycin antibiotics as positive controls. The results of this study showed (1) Secondary metabolites contained in 96% ethanol extract, ethyl acetate fraction and n-butanol fraction are phenolics, flavonoids, tannins and saponins. Terpenoids were only found in the ethanol extract. The ethyl acetate fraction found no alkaloids and the n-hexane fraction contained only steroids. (2) The 96% ethanol extract, ethyl acetate fraction and n-butanol fraction had antibacterial activity. (3) The highest antibacterial activity was shown by the ethyl acetate fraction with KHM on C. acnes at 0.375% and on S. epidermidis at 1% and KBM for both bacteria at 2.5%. (4) The equivalence value of antibacterial activity of fractions to antibacterial antibiotic clindamycin is still relatively low but still has good antibacterial activity. In conclusion, the ethanol extract and its fractions have potential as anti-acne against C. acnes and S. epidermidis bacteria.
Penghambatan Xantin Oksidase Oleh Gel Ekstrak Takokak (Solanum torvum Swartz) Berbasis Nanoteknologi Secara In Vitro Dwiyansyah, Muhammad Imam; Insyira, Rania; Mirsa, Almira Maurilla; Sawalia, Azzara Gita; Nugra, Daffa; Salmi, Salmi
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12610

Abstract

Inhibition of xanthine oxidase is one of the strategies in handling gout. This study aims to explore the potential of takokak fruit extract (Solanum torvum Swartz) in inhibiting nanotechnology-based xanthine oxidase in the form of nanoemulgel. This research is an experimental study conducted in several stages, namely qualitative phytochemical tests, quantitative identification of total flavonoid content and preparation of nanoemulgel made with 3.75% extract with variations of surfactant Tween 80 and PEG 400, namely F1 (30:30), F2 (35:25) and F3 (40:20). The ability of the extract and nanoemulgel was evaluated in inhibiting xanthine oxidase. The results showed that the ethanol extract of takokak fruit contained flavonoids, saponins, phenolics and tannins qualitatively. The total flavonoid content in the extract was 4.472 ± 0.133 mgQE. Formulation F2 has the smallest particle size (18.5 nm) and polydispersity index of 0.1313. Takokak fruit extract has almost the same inhibitory power as allupurinol with an IC50 value of 45.54 ppm. The IC50 value of nanoemulgel 3.75% takokak extract is 29.26 ppm so that the IC50 of the extract in nanoemulgel form is 1.10 ppm (45 times the IC50 of the crude extract). In conclusion, Formula F2 is the best formula in the preparation of nanoemulgel with particle size and polydispersion index and strong xanthin oxidase inhibitory activity.
STUDI PERBANDINGAN KEANEKARAGAMAN BIVALVIA DAN GASTROPODA PADA PULAU-PULAU KECIL DI BANGKA Afriyansyah, Budi; Insyira, Rania; Papingka, Tirma; Islamiyah, Umiyatul; Syazili, Ahmad; Lissoliha, Lissoliha; Edelweis, Mutia Anggita; Roshan, Rani Arizki; Meilya, Risna; Julisa, Shella Indila; Tiwi, Raka; Fauziyah, Zaenab; Rangga, M Yusuf; Septiani, Hikmah; Pratoyo, Genta Hazi; Winanto, Winanto; Lingga, Rahmad; Henri, Henri
Jurnal Ruaya : Jurnal Penelitian dan Kajian Ilmu Perikanan dan Kelautan Vol 11 No 1 (2023): Jurnal Ruaya : Jurnal Penelitian dan Kajian Ilmu Perikanan dan Kelautan
Publisher : UNIVERSITAS MUHAMMADIYAH PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (507.988 KB) | DOI: 10.29406/jr.v11i1.4369

Abstract

Penelitian ini dilakukan pada ketiga pulau kecil yang ada di Bangka Belitung yaitu Pulau Putri, Pulau Panjang dan Pulau Semujur. Tujuan penelitian ini adalah untuk mengetahui keanekaragaman bivalvia dan gastropoda berdasarkan karakteristik masing-masing pulau. Metode yang digunakan adalah metode Purposive sampling dengan teknik transek garis yang dilakukan pengambilan garis tegak lurus terhadap garis pantai. Stasiun terdiri dari 3 stasiun dengan 5 plot pencuplikan yang dibuat kerangka kuadran berukuran 50×50cm2 dengan jumlah total daerah pencuplikan adalah 15 masing-masing pulau. Analisis data menggunakan rumus keanekaragaman Shannon Wiener. Hasil penelitian menunjukkan bahwa parameter fisik dan kimia pada lingkungan ketiga pulau tergolong baik dengan suhu rata-rata 31,9℃, pH 7,395 dan salinitas 4,15%. Keanekaragaman Gastropoda lebih besar daripada keanekaragaman Bivalvia. Hal ini ditunjukkan dengan adanya 21 spesies gastropoda di Pulau Putri, 18 spesies gastropoda di Pulau Panjang, dan 7 spesies gastropoda di Pulau Semujur sedangkan bivalvia 20 spesies di Pulau Putri, 13 spesies di Pulau Panjang, dan 2 spesies di Pulau Semujur. Famili dari kelas Gastropoda yang paling banyak ditemukan adalah Cerithiidae. Berdasarkan parameter yang diukur pada lokasi penelitian dan adanya perbedaan karakteristik dari ketiga pulau menyebabkan adanya perbedaan keanekaragaman gastropoda dan bivalvia, seperti di Pulau Putri yang didominasi oleh rataan terumbu karang yang sangat luas dan rapat dengan substrat berupa pasir, yang mana kondisi tersebut mempengaruhi tingginya keanekaragaman gastropoda dan bivalvia. Adapun di Pulau Panjang di dominasi oleh ekosistem lamun dengan tipe substrat yang lumpur berpasir, keberadaan lamun dapat menjadi sumber nutrisi serta habitat bagi moluska hal tersebut yang menyebabkan tingginya keanekaragaman gastropoda dan bivalvia. Adapun Kondisi lingkungan di Pulau Semujur di dominasi oleh ekosistem lamun dengan substrat berpasir, serta terdapat pemukiman warga, banyaknya aktivitas seperti rekreasi, memancing dan eksplorasi serta pengambilan fauna untuk koleksi pribadi di Pulau tersebut menyebabkan rendahnya keanekaragaman gastropoda dan bivalvia.
Co-Authors Budi Afriyansyah Dwiyansyah, Muhammad Imam Edelweis, Mutia Anggita Fauziyah, Zaenab Henri Henri, Henri Islamiyah, Umiyatul Julisa, Shella Indila Lingga, Rahmad Lissoliha, Lissoliha Meilya, Risna Mirsa, Almira Maurilla Nugra, Daffa Papingka, Tirma Pratoyo, Genta Hazi Rangga, M Yusuf Roshan, Rani Arizki Salmi, Salmi Sawalia, Azzara Gita Septiani, Hikmah Syazili, Ahmad Tiwi, Raka winanto, winanto