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All Journal Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Oftalmologi: Jurnal Kesehatan Mata Indonesia Ophthalmologica Indonesiana
Arief Sjamsulaksan Kartasasmita
Faculty Of Medicine, Universitas Padjadjaran, Jl. Raya Bandung, Sumedang Km. 21, Jatinangor 45363
Biochemistry, Genetics & Molecular Biology Education Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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 1 
Structure and Macular Sensitivity Characteristic After Silicone Oil Removal in Primary Rhegmatogenous Retinal Detachment Haryono, Aditia Apriyanto; Widyanatha, Made Indra; Iskandar, Erwin; Kartasasmita, Arief Sjamsulaksan; Virgana, Rova; Ihsan, Grimaldi
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 4 No 3 (2022): Jurnal Oftalmologi
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v4i3.42

Abstract

Introduction: Silicone oil (SO) is an endotamponade to manage several retinal detachments.The emulsification of silicone oil is one of the complications that may occur in several patients. Retinal macular changes may occur even with successful tamponade. Purpose: to describethe structure and macular sensitivity characteristic after silicone oil removal in primary rhegmatogenous retinal detachment (RRD). Methods: a prospective, descriptive case series study of who underwent SO tamponade for primary RRD. Optical coherence tomography (OCT) and microperimetry (MP-3) were conducted before SO removal and one week after SO removal. Result: There were nine eyes that met the criteria. The mean age of the patients was 53.3±14 years. Most of the patients use silicon 1300 (66.67%) and under six months (77.8%) duration of silicone tamponade. After silicone oil removal, mean macular sensitivity in the central fovea decreased from 12.44 dB to 12.11 dB, and parafovea increased from 18.33 dB to 19.00 dB.The mean macular thickness in the fovea decreased from 269.89μm to 260μm. The mean macular thickness in parafovea was an increase from 316.16 to 328.00μm Conclusion: There was an increase in macular sensitivity and thickness at parafovea after one- week silicone oil removal in primary rhegmatogenous retinal detachment.
GAMBARAN KEPATUHAN BEROBAT PASIEN RETINOPATI DIABETIK DI PMN RS MATA CICENDO 2021?2022 Naqiya, Wafa; Virgana, Rova; Kartasasmita, Arief Sjamsulaksan
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 5 No 2 (2023): Jurnal Oftalmologi Vol 5 No 2 2023
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v5i2.54

Abstract

Pendahuluan: Retinopati diabetik (RD) merupakan komplikasi mikrovaskular penyakit diabetes melitus dengan angka pertumbuhan tinggi. Kepatuhan melakukan pemeriksaan rutin dan menjalankan tindakan khusus dapat mencegah progresivitas penyakit ini. Namun, penelitian mengenai gambaran kepatuhan berobat pasien retinopati diabetik belum pernah dilakukan di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran kepatuhan berobat pasien retinopati diabetik di PMN RS Mata Cicendo.  Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan metode cross sectional, menggunakan data sekunder dari EMR, dan dilakukan pada periode 1 Januari 2021–31 Desember 2022 di PMN RS Mata Cicendo. Kepatuhan dinilai berdasarkan kepatuhan menjalankan masa awal pengobatan dan diukur melalui data tanggal registrasi, tindakan, dan perencanaan. Hasil penilaian kepatuhan kemudian dikelompokkan berdasarkan derajat retinopati diabetik, tipe diabetes melitus, jenis tindakan, jenis kelamin, usia, pekerjaan, pendidikan terakhir, dan domisili.  Hasil: Penelitian ini melibatkan 887 rekam medis dan 533 (60,1%) di antaranya dikategorikan patuh. Data menunjukkan persentase kepatuhan >60% pada pasien derajat berat seperti Proliverative Diabetic Retinopathy (61,6%); berjenis kelamin perempuan (60,2%); berusia muda kelompok 25–34 tahun (77,4%); berdomisili di Bandung Raya (64,4%) atau luar Jawa Barat (63,5%); berpendidikan terakhir tinggi sarjana muda (68,9%); bekerja sebagai pegawai swasta (67,1%), pengajar (72,7%), wiraswasta (61,3%), atau pensiunan (66,7%); memiliki tipe diabetes melitus terspesifikasi non-insulin dependent (64,2%) atau insulin dependent (80,9%); serta mendapat rekomendasi tindakan laser (64,1%).  Kesimpulan: Secara umum kepatuhan berobat pasien retinopati diabetik di PMN RS Mata Cicendo sudah mencapai >60%. Kepatuhan pasien kontrol dengan jangka waktu menengah (1–3 bulan), panjang (>6 bulan) masih harus ditingkatkan.
Complete Resolution of Central Serous Chorioretinopathy Cases Treated with Low Power Mode Laser Technology : A Novel Approach: Poster Presentation - Case Series - Resident Setiawan, Grace; Virgana, Rova; Widyanatha, Made Indra; Ihsan, Grimaldi; Kartasasmita, Arief Sjamsulaksan; Iskandar, Erwin
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/qr43j813

Abstract

Introduction : Central serous chorioretinopathy (CSC) is an idiopathic condition mostly affecting men in their 20s to 50s. It is characterized by serous fluid accumulation behind the neurosensory retina resulting in a localized macular detachment. Aldosterone-receptor antagonist and photodynamic laser therapy are the current mainstay of treatments, although most CSC cases can resolves spontaneously within 2 to 3 months. Low power mode (LPM) laser has emerged as a new effective technology to treat CSC. Case Illustration : Case 1: A 50-year-old male was diagnosed with recurrent chronic CSC since 2 months ago. His visual acuity declined even after given oral aldosterone receptor antagonist for two weeks, so he was scheduled to undergo LPM. After three weeks of laser treatment, CSC resolved and the visual acuity improved (Figure1). Case 2 : A 47-year-old male complained of decreased vision and metamorphopsia on his right eye since two weeks ago. He was diagnosed with CSC and underwent LPM. Three weeks after LPM, his vision improved and the metamorphopsia resolved (Figure2). LPM helps the migration of retinal pigment epithelium (RPE) cells to restore the outer blood-retinal barrier through expression of heat shock proteins. We used MC-500ViXi laser system (Nidek Co., Gamagori, Japan) and the laser parameters used in this study were 100?m spot size, 0.01s exposure time, 0.25-0.5 spacing, and 30% LPM ratio. Discussion : Conclusion : LPM is a new yet promising treatment modalities to treat acute and chronic CSC. Its low power nature makes LPM a safe choice of treatment with less damage to the surrounding retina.
Trends in CTGF Expression in Renal and Chorioretinal Tissues Following Metformin and SGLT2 Inhibitor Treatment in Diabetic Rats Maimun Syukri; Lia Meuthia Zaini; Arief Sjamsulaksan Kartasasmita; Tjahjono Darminto Gondhowiardjo; Ronny Lesmana; Putri Nabillah Mulya
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3886

Abstract

BACKGROUND: Connective tissue growth factor (CTGF) plays a central role in fibrotic processes affecting both renal and retinal tissues in diabetes. Although sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to exert renoprotective and antifibrotic effects, their impact on CTGF expression in renal and retinal tissues has not been clearly established. This preliminary study was conducted to evaluate whether SGLT2 inhibitors (SGLT2i) could influence CTGF expression in the kidneys and eyes of diabetes-induced rats.METHODS: After two weeks of adaptation, 24 rats were randomized and distributed equally into four groups (n=6 each): 1) Healthy Control, healthy rats without diabetic induction; 2) Negative Control, diabetic rats induced with streptozotocin (STZ) without treatment; 3) Metformin Group, diabetic rats treated with metformin; and 4) SGLT2i Group, diabetic rats treated with empagliflozin. Following eight weeks of intervention, CTGF expression was analyzed by Western blot in renal tissue (right kidney) and chorioretinal tissue (right eye). Four samples per group yielded analyzable bands and were included in the final quantification.RESULTS: In renal tissue, CTGF levels (mean±SD) were highest in Negative Control Group (0.81±0.06). Both the Metformin Group (0.58±0.14) and SGLT2i Group (0.57±0.33) demonstrated a trend toward reduced CTGF expression. In chorioretinal tissue, CTGF values were relatively similar across groups (Healthy Control: 0.67±0.05; Negative Control: 0.63±0.12), with Metformin Group (0.61±0.12) and SGLT2i Group (0.64±0.22) showing a modest reduction trend.CONCLUSION: In diabetic rats, CTGF expression levels are markedly increased. Following treatment with metformin and SGLT2i, CTGF expression demonstrates a noticeable reduction trend.KEYWORDS: SGLT2 inhibitor, metformin, connective tissue growth factor, cellular communication network factor 2, renal, retina
The Role of NMDA, GLUR4, NF-κB, and Nrf2 in Glaucoma Pathophysiology: Evidence from Wistar Rat Model Maharani, Maharani; Kartasasmita, Arief Sjamsulaksan; Rahmi, Fifin Luthfia; Rachmawati, Banundari
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.30645

Abstract

Background: Glaucoma is a neurodegenerative disorder involving retinal ganglion cell loss. Elevated intraocular pressure activates the N-methyl-D-aspartate (NMDA) and Glutamate Receptor 4 (GluR4), inducing oxidative stress via the nuclear factor-kappa B (NF-κB) pathway and triggering antioxidant responses through the nuclear factor erythroid 2-related factor 2 (NRF2) pathway, which contributes to disease progression and informs therapeutic insights.Objective: To explore NMDA, GluR4, NF-κB, and NRF2 roles in glaucoma pathophysiology and identify therapeutic targets using Wistar rat models.Methods: This experimental research was conducted using a post-test-only control group design. Fourteen male Wistar rats were divided into two groups (n = 7). The glaucoma group underwent episcleral veincauterization (EVC) to induce a high intraocular pressure (IOP), whereas the control group remained untreated. Four weeks after EVC, evaluations included the expression of NMDA, GluR4, NF-κB, and NRF2 receptors. Statistical significance was defined as a p-value < 0.05. Statistical analysis was performed using a parametric independent t-test and a Mann-Whitney U test.Results: The mean NMDA expression was significantly higher in the glaucoma group (14.50 ± 4.23) compared to the control group (7.74 ± 3.24, p=0.006). Similarly, the mean GluR4 expression was elevated in the glaucoma group (10.77 ±2.40) compared to the control group (3.03 ± 4.05, p = 0.012). The mean NF-κB expression was 14.96 ± 4.87 in the glaucoma group, significantly higher than 6.72 ± 1.84 in the control group (p = 0.003). Conversely, the mean NRF2  expression was significantly lower in the glaucoma group (3.98 ± 1.10) than in the control group (7.18 ± 1.61, p < 0.001).Conclusion: The study highlights significant changes in all four variables, where NMDA, GluR4, NF-κB expressions were higher, and NRF2 expression was lower
Co-Authors Banundari Rachmawati Fifin Luthfia Rahmi Haryono, Aditia Apriyanto Ihsan, Grimaldi Iskandar, Erwin Lia Meuthia Zaini Maharani Maharani, Maharani Maimun Syukri Naqiya, Wafa Putri Nabillah Mulya Ronny Lesmana Rova Virgana Setiawan, Grace Tjahjono Darminto Gondhowiardjo Widyanatha, Made Indra