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Desi Aliefia
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EFEK PEMBERIAN PROBIOTIK PADA PENDERITA SINDROM METABOLIK; STUDI LITERATUR Desi Aliefia; Abdullah, Dessy; Tri Puspita Prihatinningrum AF; Zukhri Zainun
Nusantara Hasana Journal Vol. 4 No. 3 (2024): Nusantara Hasana Journal, August 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i3.1218

Abstract

Developments in probiotic therapy have shown potential to help improve gastrointestinal health. Several studies have been conducted to test the benefits of probiotic use, both in the context of prevention and treatment of various diseases. This article reviews various research results related to the potential use of probiotics in metabolic syndrome. The literature discussing the mechanism of action of probiotics and clinical evidence for their use in conditions such as diabetes, dyslipidemia, and non-alcoholic liver disease are comprehensively reviewed. Although further research is needed, the management of gut microbiota through probiotic administration shows promising prospects as a complementary strategy in the management of metabolic syndrome. The imbalance of gut microbiota, known as dysbiosis, can contribute to the development of various metabolic diseases (Patel, R. and DuPont, L, H., 2015). Recent studies have shown that probiotic administration can improve the composition and function of gut microbiota, thereby helping to prevent or improve symptoms of various diseases associated with metabolic syndrome (Shi, Q. et al., 2022). One of the main mechanisms of probiotics is through their ability to maintain the balance of gut microbiota. By suppressing the growth of pathogenic bacteria and improving the composition of the gut microbiota, probiotics can help overcome problems associated with dysbiosis.
HUBUNGAN TINGKAT KECEMASAN DENGAN TINGKAT PENGETAHUAN PASIEN YANG AKAN DILAKUKAN SECTION CAESAREAN METODE ERACS DI RUMAH SAKIT HERMINA PADANG Anita Darmayanti; Aryaldy Zulkarnaini; Desi Aliefia; Dian Budianti; Rezy Saputra
Nusantara Hasana Journal Vol. 3 No. 4 (2023): Nusantara Hasana Journal, September 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i4.1278

Abstract

Pregnancy always has risks that may cause mortality, morbidity and disability in the mother or baby. The Maternal Mortality Rate (MMR) is an indicator to determine the success of maternal health efforts. Various efforts have been made to reduce maternal mortality, one of which is by conducting regular antenatal checks to check the condition of the mother and fetus on a regular basis to reduce the severity of obstetric complications and increase awareness of the danger signs of pregnancy. More knowledge and understanding is needed. Increasing knowledge of the danger signs of pregnancy is considered a strategy that encourages the use of skilled care during pregnancy. This study aims to describe the knowledge of pregnant women about danger signs of pregnancy at the Lubuk Buaya Padang Health Center in 2022-2023. The scope of this research is the field of obstetric medicine. The research was conducted in August 2022 - January 2023. The type of research is descriptive. The affordable population in this study were pregnant women who came to the Lubuk Buaya Padang Health Center in 2022. The type of data was taken, namely primary data of 55 samples using a simple random sampling technique using a questionnaire instrument that had been tested for validity and reliability. It was found that the highest age group for pregnant women was the non-risk age group (20-35 years) with 49 people (89.1%). The highest education for pregnant women was in the high school group with 35 people (63.6%). The most pregnant women in the non-working group were 40 people (72.7%). The highest number of gravid pregnant women was the multigravid group with 35 people (63.6%). The knowledge of pregnant women about danger signs of pregnancy was mostly in the group of pregnant women with good knowledge of 37 people (67.3%). Based on the identification of the description of the knowledge of pregnant women about the danger signs of pregnancy at the Lubuk Buaya Health Center for the period August 2022 - January 2023, it can be concluded that the knowledge of pregnant women about the danger signs of pregnancy is mostly good.
NEUROENDOCRINE CARCINOMA PARU DENGAN PRESENTASI SINDROM VENA KAVA SUPERIOR: LAPORAN KASUS DAN TINJAUAN PUSTAKA Desi Aliefia
Nusantara Hasana Journal Vol. 5 No. 1 (2025): Nusantara Hasana Journal, June 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i1.1682

Abstract

Neuroendocrine carcinoma (NEC) is a heterogeneous group of neoplasms originating from neuroendocrine cells in the lung. High-grade subtypes such as small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC) are characterized by rapid growth, early metastasis, and a poor prognosis. Early diagnosis through minimally invasive cytology procedures such as transthoracic needle aspiration – rapid on-site evaluation (TTNA-ROSE) is crucial for management. We report a 54-year-old man, a heavy smoker, who presented with progressive shortness of breath, productive cough, hoarseness, chest pain, and night sweats. A chest radiograph revealed a mediastinal mass. TTNA-ROSE, lymph node FNA, and core biopsy demonstrated typical cytomorphology of NEC with salt-and-pepper chromatin, molding, and background necrosis. Immunocytochemistry revealed synaptophysin positivity in >50% of tumor cells. The patient underwent radiotherapy but experienced clinical deterioration on follow-up. The TTNA-ROSE procedure facilitated the early diagnosis of NEC by assessing sample adequacy and expediting additional testing. Differential diagnoses include thymic SmCC, mediastinal lymphoma, Ewing sarcoma/PNET, metastatic SmCC from other organs, and poorly differentiated NSCLC. Current therapies include platinum-based chemotherapy, immunotherapy (pembrolizumab, nivolumab), somatostatin analogs (octreotide, lanreotide), and targeted therapies such as everolimus. The prognosis for NEC remains poor, with a median survival of 12–18 months in SCLC. This case emphasizes the critical role of TTNA-ROSE and immunocytochemistry in the diagnosis of pulmonary NEC. Early diagnosis and a multidisciplinary approach are necessary to improve patient outcomes.
DIABETES GESTASIONAL SEBAGAI PREDIKTOR DINI PENYAKIT KARDIOMETABOLIK JANGKA PANJANG: TINJAUAN LITERATUR Wisda Widiastuti; Abdullah, Dessy; Aryaldy Zulkarnaini; Arief Rinaldy; Desi Aliefia; Gangga Mahatma
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1864

Abstract

Gestational diabetes mellitus (GDM) has long been regarded as a transient metabolic disorder limited to pregnancy. However, growing scientific evidence indicates that GDM represents an early marker of long-term metabolic vulnerability in women. This literature review aims to synthesize current evidence on the association between GDM and the risk of type 2 diabetes mellitus, cardiovascular disease, and other metabolic disorders after pregnancy, as well as its implications for postpartum care and interdisciplinary collaboration. A literature search was conducted using the PubMed, Scopus, and Web of Science databases, focusing on articles published over the past ten years. The review findings show that women with a history of GDM have a significantly increased risk of developing type 2 diabetes mellitus, as well as a higher risk of cardiovascular disease compared with women without a history of GDM, even among those who do not progress to overt diabetes. The underlying mechanisms include persistent insulin resistance, pancreatic β-cell dysfunction, chronic low-grade inflammation, the role of the placenta, and the potential contribution of the gut microbiota. In conclusion, GDM should be understood as an early predictor of long-term cardiometabolic disease. Structured and collaborative postpartum care involving obstetrics and internal medicine is essential to reduce the future burden of disease.
Co-Authors Abdullah, Dessy Anita Darmayanti Arief Rinaldy Aryaldy Zulkarnaini Dian Budianti Gangga Mahatma Rezy Saputra Tri Puspita Prihatinningrum AF Wisda Widiastuti Zukhri Zainun