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All Journal ITEj (Information Technology Engineering Journals) Majalah Patologi Indonesia
Rezeki, Dewi Sri
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Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Health Professions Mathematics Public Health

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High Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Correlates with High Grade of Clear Cell Renal Cell Carcinoma Rezeki, Dewi Sri; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Alferraly, T. Ibnu; Lukito, Joko S.; Betty, Betty
Majalah Patologi Indonesia Vol. 33 No. 2 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.581

Abstract

Background Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype in renal cell tumors (RCT). This is a very aggressive cancer, often diagnosed at advanced stage leading to increase morbidity and mortality rates. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX-4) expression plays role in the regulation of several cancer types. The expression of NOX-4 is associated with a poorer degree of differentiation and a shorter survival in RCT. Therefore, NOX-4 expression is predictor of prognosis and potential therapeutic target. Research on the correlation of NOX-4 expression in RCTs is still very limited, while Correlation of NOX-4 expression in ccRCC does not exist yet.   Objective To assess the relationship between NOX-4 expression and ISUP grading in ccRCC.   Method In this study, 30 slide samples and ccRCC paraffin blocks were diagnosed histopathologically at Department of Anatomic Pathology of H. Adam Malik General Hospital from January 2012 to April 2022. All clinicopathological data were taken from medical records/pathology archives. The expression of NOX-4 immunohistochemical was assessed in nucleus and cytoplasm of tumor cells. The assessment was carried out semiquantitatively based on intensity and percentage of expressed tumor cells. The relationship between NOX-4 expression and ISUP grading was assessed using Fisher's exact test.   Results Of the 30 ccRCC samples, high grade ccRCC was found in 21 cases (70%) and strong expression of NOX-4 in cytoplasm and nucleus in 20 cases (66.7%). Strong expression of NOX-4 in high grade ccRCC was found in 17 cases (81.0%). A significant relationship was observed between NOX-4 expression and ISUP grading on ccRCC with a p-value of 0.030 (p<0.05) using Fisher's exact test.   Conclusion There is a significant relationship between NOX-4 expression and ISUP grading in ccRCC. Therefore, NOX-4 expression can be used for the prognosis of ccRCC and therapy development.
Analisis System Quality dan Service Quality terhadap Tingkat Kepercayaan Nasabah pada Digitalisasi Pembukaan Rekening Bank Rezeki, Dewi Sri; Sfenrianto, Sfenrianto
ITEJ (Information Technology Engineering Journals) Vol 7 No 2 (2022): December
Publisher : Pusat Teknologi Informasi dan Pangkalan Data IAIN Syekh Nurjati Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24235/itej.v7i2.93

Abstract

Bank adalah badan usaha yang menghimpun dana dari masyarakat dalam bentuk simpanan dan menyalurkannya kepada masyarakat dalam bentuk kredit dan atau bentuk - bentuk lainnya dalam rangka meningkatkan taraf hidup masyarakat. Perkembangan bisnis perbankan digital saat ini merupakan salah satu agenda penting dalam industri Perbankan Indonesia. Kebutuhan akan transformasi menjadi prioritas utama bagi perusahaan, agar lebih agile dalam pasar yang berubah dengan cepat. Penggunaan technology informasi pada Bank telah mengubah pola pikir masyarakat dalam bertransaksi. Hal ini berdampak pada digitalisasi pembukaan rekening. Masyarakat dapat dengan mudah membuka rekening dimana saja dan kapan saja. Seiring dengan kemudahan pembukaan rekening digital, perlu diperhatikan tingkat kepercayaan yang diakibatkan dari penggunaan aplikasi tersebut. Saat ini, Bank dengan modal inti tertinggi yaitu tiga puluh tirilun rupiah telah menerapkan pembukan rekening secara online. Penelitian ini menganalisis sistem kepercayaan (trust) nasabah terhadap system quality dan service quality dengan Metode PLS-SEM dan hasil penelitian ini diharapkan bisa mengetahui sejauh mana kepercayaan nasabah setelah menggunakan pembukaan rekening secara online.
The Correlation of Clinicopathological Characteristics in Clear Cell Renal Cell Carcinoma (ccRCC) with Immunohistochemical Expression of Light Chain 3 B (LC3-B) Rezeki, Dewi Sri; Alferraly, T. Ibnu; Chrestella, Jessy; l, Lidya Imelda; Lukito, Joko S.
Majalah Patologi Indonesia Vol. 34 No. 2 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.680

Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype in RCTs. This tumor is very aggressive and is often diagnosed at an advanced stage. LC3-B is a specific autophagy marker that plays a role in ccRCC. Research regarding the relationship between clinicopathological characteristics of ccRCC and LC3-B expression is still very limited and controversial. Objective: To assess the relationship between clinicopathological characteristics of ccRCC and LC3-B immunohistochemical expression. Materials and methods: This study used 22 slide samples/paraffin blocks of ccRCC cases that had been diagnosed histopathologically at the Anatomic Pathology Unit of H. Adam Malik General Hospital, Medan from January 2017 to April 2023. All clinicopathological data was taken from medical records/pathology archives. LC3-B expression was assessed in the cytoplasm of tumor cells with assessment semiquantitatively based on the multiplication of intensity and percentage of expressed tumor cells. Statistical analysis was carried out using Fischer's Exact and Kruskal Wallis tests. Results: Among the 22 ccRCC samples, weak expression of LC3-B was found in the age group ≤60 years, male gender, tumor size >10 cm, positive LVI, negative PNI, grade IV, severe stromal TILs, mild intratumoral TILs and low budding in intratumoral budding tumors. Fischer's Exact and Kruskal Wallis statistical tests showed that there was no significant relationship between gender, tumor size, LVI, PNI, ISUP grading, TILs and peritumoral tumor budding with LC3-B expression. Conclusion: There was no significant relationship between clinicopathological characteristics of ccRCC with LC3-B expression (The Null Hypothesis is accepted (H0 ρ=0)). Key words: clinicopathology, ccRCC, LC3-B
Co-Authors Alferraly, T. Ibnu betty betty Chrestella, Jessy l, Lidya Imelda Laksmi, Lidya Imelda Lukito, Joko S. Mariedina, Causa Trisna Sfenrianto, Sfenrianto