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All Journal JPBIO (Jurnal Pendidikan Biologi) Jurnal AKAL: Abdimas dan Kearifan Lokal Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Tungka, Endrico Xavierees
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Humanities Automotive Engineering Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Public Health Social Sciences Transportation

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TINGKAT PENGETAHUAN TALASEMIA, PENYAKIT MENULAR SEKSUAL DAN KESEHATAN REPRODUKSI PADA REMAJA USIA SEKOLAH MENENGAH PERTAMA Wratsangka, Raditya; Tungka, Endrico Xavierees; Krishna Murthi, Aditya; Gushaendri, Idman; Shafia, Faiza
Jurnal AKAL: Abdimas dan Kearifan Lokal Vol. 5 No. 1 (2024): Jurnal AKAL : Abdimas dan Kearifan Lokal
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/akal.v5i1.18287

Abstract

This PKM Activity aims to determine the level of knowledge of adolescents about thalassemia, sexually transmitted diseases, and reproductive health. The method used in this PKM is material presentation/ counseling and direct interviews using a questionnaire linked to the Google Form application. The results of this PKM activity were obtained as follows; The source of information that plays a dominant role in conveying sexually transmitted infections-HIV/AIDs is the internet, namely 57(53.4%). As many as 76(70.4%) students did not know about thalassemia. Surveys on sexually transmitted diseases/AIDs show that the average junior high school teenager has sufficient knowledge, namely above 50%. Surveys on reproductive health knowledge show that the average junior high school teenager has good knowledge about the physical changes that occur during puberty, including; 1) an Increase in muscle mass (30%), 2) a change in voice (71.8%), 3) hair growth on the face and pubic area (95%), 4) increased sex drive (33.6%). 5) enlarged breasts (17.3%), 6) menstruation started (40.9%). A survey limited to female respondents showed that the level of knowledge about the female reproductive cycle related to the fertile period in junior high school teenagers was around 24 (43.3%) respondents, but 30 (50%) respondents did not know this. The level of knowledge about the fertile period and the possibility of pregnancy occurring in that period are: 1) the response of not knowing was 26 (43.3%), people, 2) immediately after menstruation ended 14 (23.3%), 3) in the middle between two menstruations as many as 14 (23.3%). From the results obtained, it can be concluded that the level of knowledge of junior high school adolescents regarding thalassemia is still very poor, while for sexually transmitted infections and reproductive health, it is at an average level. It is hoped that after participating in PKM, teenagers will have a better level of knowledge than before.
The Influences of Medical Students' Consent to Participate in Thalassemia Research Wratsangka, Raditya; Adriani, Donna; Tungka, Endrico Xavierees; Murthi, Aditya Krishna
Kesmas Vol. 19, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

An effective way of learning about thalassemia, a complex public health issue with multiple perspectives, is through participating in research. This study used an inductive approach to presume the influencing factors of students' consent to participate in thalassemia research voluntarily. Nested in the preliminary stage of a research series on thalassemia, this study used a consecutive sampling to recruit 140 medical undergraduates. Their knowledge, experience, and attitude to thalassemia and the perception of self-quality life were assessed using self-administered questionnaires. Blood samples were drawn for carrier screening. Students' GPAs were collected from faculty records. Of 140 participants, only 123 had at least heard of thalassemia, and their data was used in the analysis. Most participants had fairly good but incomplete knowledge of inheritance patterns, antenatal screening, and thalassemia management. Premarital screening was known and received the most positive attitudes from participants. Inductively, academic performance and carrier status curiosity were presumed to influence students' consent to participate. With the limitation of an inductive approach, further study with a specific design is needed to closely investigate student perspectives on research and their drives to get involved.
Gene expression of sirtuin-1 in adult with hypertension Yohana, Yohana; Faradilla, Meutia Atika; Tungka, Endrico Xavierees; Kurniasari, Kurniasari
JPBIO (Jurnal Pendidikan Biologi) Vol 10, No 1 (2025): April 2025
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v10i1.4456

Abstract

SIRT1 is a key member of the sirtuin family, exerts a unique protective effect on endothelial cells by modulating various proteins, and has a role as an anti-aging biomarker. Hypertension is pathology chronic pathological condition that disrupts ROS and antioxidants. Little evidence showed that sirtuin has a role in chronic oxidative stress. Therefore, the objective of this study was to analyze the relative expression of Sirtuin-1 in hypertension. This is a case-control study with 30 subjects, adults 50-60 years old in each group. JNC 8 was used to determine blood pressure. Quantitative Real Time PCR was used to calculate the level of Sirt-1. The Livak method was used for relative expression. JASP software was used for data analysis. Our study showed Sirtuin-1 mRNA expression was significantly lower in the hypertension group than the normotension group. It was 0.52 fold lower in hypertension. Sirtuin-1 stimulates antioxidants such as superoxide dismutase and catalase through FOXO-dependent signaling. It has a similar role to antioxidants for eliminating ROS. Sirtuin-1 expression is significantly reduced in individuals with hypertension, suggesting its potential role in oxidative stress regulation and its value as a biomarker for vascular aging and hypertension-related endothelial dysfunction.Keyword: Sirtuin-1, hypertension, expression, mRNA
Co-Authors Adriani, Donna Faradilla, Meutia Atika Gushaendri, Idman Krishna Murthi, Aditya Kurniasari Kurniasari Kurniasari Kurniasari Raditya Wratsangka, Raditya Shafia, Faiza Yohana