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Edukasi dan Pelatihan Pengolahan Tanaman Obat Untuk Menunjang Kesehatan Masyarakat Kelurahan Angke Meiyanti; Yohana; Eveline Margo; Erlani Kartadinata; Juni Chudri
Jurnal Pengabdian Nasional (JPN) Indonesia Vol. 4 No. 2 (2023): Mei
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) AMIK Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpni.v4i2.271

The utilization of traditional medicine derived from nature has increased its use in recent years, this is in line with the current trend of returning to nature. The use of traditional medicine in the form of herbal medicine has been done since ancient times and has been passed down from generation to generation. However, the use of TOGA as medicine is still low in prevalence, especially in the DKI Jakarta area according to 2018 Riskesdas data. The level of knowledge is one of the factors associated with the utilization of herbal medicine. Limited knowledge about medicinal plants and how to process and make herbal medicines properly and correctly becomes an obstacle to utilization. Various benefits can be obtained from the utilization of TOGA both in terms of benefits, safety, and economic aspects, especially for community groups with economic limitations. This community service activity is carried out by providing education on useful medicinal plants, and plant parts that can be used as medicines and training on processing medicinal plants using household appliances. The purpose of this activity is to increase knowledge, utilization, and interest in processing medicinal plants.

Manfaat Aktivitas Untuk Lanjut Usia Masa Pandemi Covid 19 Di Kelurahan Angke Meiyanti Meiyanti; Yohana; Eveline Margo; Juni Chudri
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 05 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Elderly is a natural life cycle and cannot be avoided by every human being. Increasing age will cause physical and mental changes, there will be a decrease in the function and ability of a person. At the time of entering the elderly, automatically most elderly people will reduce their daily activities, which will affect their quality of life. The purpose of this community service activity is to provide education for the elderly on the types of activities and benefits. This activity was carried out in Angke Village, West Jakarta. This activity method is carried out by providing education, checking health status, and personal health consultations to the health team. This activity involved 22 elderly people. The results of the activity mean the age of the elderly is 68 years, and 86% of the participants are included in the age group < 75 years. As many as 68% of elderly participants had controlled chronic diseases, with hypertension being the most dominant. As many as 66% of the 22 elderlies were categorized as elderly with good activities.

Edukasi dan Pelatihan Pengolahan Tanaman Obat Untuk Menunjang Kesehatan Masyarakat Kelurahan Angke Meiyanti; Yohana; Eveline Margo; Erlani Kartadinata; Juni Chudri
Jurnal Pengabdian Nasional (JPN) Indonesia Vol. 4 No. 2 (2023): Mei
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) STMIK Indonesia Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpni.v4i2.271

The utilization of traditional medicine derived from nature has increased its use in recent years, this is in line with the current trend of returning to nature. The use of traditional medicine in the form of herbal medicine has been done since ancient times and has been passed down from generation to generation. However, the use of TOGA as medicine is still low in prevalence, especially in the DKI Jakarta area according to 2018 Riskesdas data. The level of knowledge is one of the factors associated with the utilization of herbal medicine. Limited knowledge about medicinal plants and how to process and make herbal medicines properly and correctly becomes an obstacle to utilization. Various benefits can be obtained from the utilization of TOGA both in terms of benefits, safety, and economic aspects, especially for community groups with economic limitations. This community service activity is carried out by providing education on useful medicinal plants, and plant parts that can be used as medicines and training on processing medicinal plants using household appliances. The purpose of this activity is to increase knowledge, utilization, and interest in processing medicinal plants.

Edukasi Penanganan Nonfarmakologi Nyeri Otot Kronis Margo, Eveline; Kartadinata, Erlani; Meiyanti; Yohana; Murthi, Aditya
Jurnal Pengabdian Nasional (JPN) Indonesia Vol. 5 No. 3 (2024): September
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) STMIK Indonesia Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpni.v5i3.923

Chronic pain can result from various clinical conditions and may persist for more than three months. The symptoms can range from mild to severe. While chronic pain can be associated with various diseases, its exact cause sometimes remains unclear. In 2019, data from the National Health Interview Survey in the United States indicated that approximately 1 in 5 adults experienced chronic pain, with over 7% frequently limiting their activities due to this condition. However, there is no comparable data available for Indonesia. Chronic pain restricts activities and can decrease a person’s quality of life. Various options are available for pain management, one of which is non-pharmacological therapy, including hot-cold compresses, massage and stretching techniques, music therapy, and aromatherapy. These therapies aim to improve bodily function, regulate emotions, reduce weakness, stress, and anxiety, and decrease the need for pain medication. Gout is among the most common causes of chronic pain, with a prevalence of 3.9% in the US, 2.5% in Europe, and 7.3% in Indonesia, according to Riskesdas (2018). Based on this, local citizens were provided with education about pain management. This community service activity involved educating citizens on non-pharmacological treatments for chronic pain management and offering health services to residents of Angke. The purpose was to increase knowledge about non-pharmacological treatments for managing chronic pain. This activity was conducted on April 27th, 2024, from 07.00 to 12.00 at the Dhammasavana School in the Angke sub-district area, West Jakarta. The activities proceeded smoothly and in an orderly manner. A comparison of citizens’ knowledge before and after the education revealed a 58.18% increase in knowledge, contributing to improved welfare among the local residents.

mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.

PERAN PENANDA LC3 SEBAGAI FUNGSI AUTOFAGI PADA AGING Xavierees, Endrico; Yohana, Yohana; Faradilla, Meutia Atika; Yastani, Deasyka; Anastasya, Karina Shasri; Suweino, Suweino
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 10, Nomor 1, Januari 2025
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v10i1.21848

Autofagi adalah proses kompleks yang masih perlu diteliti lebih dalam. Proses ini ditandai dengan adanya pembentukan membran oleh peran protein spesifik yang disebut LC3, yang memainkan peran penting dalam mekanisme autofagi. Autofagi adalah bagian penting dari proses metabolisme, karena melibatkan pergerakan organel dari limbah ke autofagosom. Proses ini difasilitasi oleh adanya fagofor dan isolasi membran, yang penting untuk pembentukan autofagosom. Autofagosom kemudian membentuk struktur kompleks dengan lisosom, yang kemudian diubah menjadi autolisosom dan bahan yang terdegradasi. Secara umum juga dikenal dengan makroautofagi namundapat ditemukan jenis lain seperti xenofagi, chaperon-mediated autofagi. Merupakan proses penting dalam menjaga keseimbangan organ-organ internal tubuh, Autofagi juga terlibat dalam pengaturan berbagai proses fisiologis, seperti sekresi insulin, pengaturan gula darah, dan respons imun. Aging mulai dihubungkan dengan autofagi dan masih memiliki banyak ruang yang perlu didalami. Memiliki peran penting dalam aging, kehamilan dan kasus kehamilan lain seperti hambatan pertumbuhan janin, kelahiran preterm, dan Diabetes Gestasional yang banyak ditemukan pada Wanita dengan usia lebih tinggi. Mulai banyak penelitian yang menghubungkan autofagi dengan bertambahnya usia. Hasil Penelitian sebelumnya menunjukkan hubungan erat sehingga mendorong penelitian lebih lanjut untuk menjelaskan fungsi Autofagi pada aging.

Vitamin D receptor polymorphism associated with obesity in productive age population: A cross-sectional study Yohana; Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Zuraida, Reni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 1, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss1.art6

Background: Obesity is influenced by genetic factors, lifestyle, and environmental factors. This increase in obesity gives rise to various chronic disease problems.Objectives: This study aimed to identify genetic variations of Vitamin D receptors and determine the relationship to obesity in terms of body mass index and body fat percentage in the working group.Methods: This study is an analytical observational study with a cross-sectional research design approach in the Jembatan Dua area, Angke sub-district, West Jakarta. The research instrument used was a questionnaire to obtain characteristic data, as well as an examination of VDR gene variations rs1544410, rs2228570, rs7975232, and PCR examination to obtain data on gene variation.Results: The results obtained are as follows: the average age of subjects was 42.24, with 58.1% females. A total of 39 (69.1%) are Javanese. Thirty-one (50%) subjects were included in the category of obesity (BMI> 25), and 41 (66.1%) subjects were obese category based on the body fat percentage. The results of bivariate analysis obtained SNP VDR FoxI gene obtained a significant relationship with body mass index with a p-value of 0.047, while the VDR BsmI gene obtained a statistically meaningful relationship with body fat percentage with a p-value of 0.043.Conclusion: FoxI and BsmI VDR polymorphisms are associated with body mass index and body fat percentage.

Edukasi Penggunaan Tensimeter Digital pada Pemeriksaan Tekanan Darah dengan Status Gizi pada Lansia Kelurahan Angke, Jakarta Barat Yohana; Meiyanti; Margo, Eveline; Atika Faradilla, Meutia; Xavierees, Endrico; Kurniasari
Jurnal Dharma Bhakti Ekuitas Vol. 9 No. 2 (2025): Jurnal Dharma Bhakti Ekuitas
Publisher : Universitas Ekuitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52250/p3m.v9i2.950

Abstract The prevalence of hypertension accompanied by obesity is increasing. This not only happens in developed countries, but is also a problem in developing countries. Hypertension with obesity presents new problems in the management of hypertension. Medical therapy alone is not enough, there must be intervention to reduce and control blood pressure, lose weight and change lifestyle. The aim of this service is to increase public awareness of high blood pressure and obesity so that it can reduce morbidity and death rates due to complications of high blood pressure. This service is carried out by checking participants' blood pressure, Body Mass Index, education and teaching participants how to use a blood pressure monitor independently at home to control blood pressure. There were 50 service participants who attended. The age range of participants is 40 to 75 years with the average age of service participants being 2.75 years. There were 35 female participants while there were 15 male participants. There were 33 participants diagnosed with high blood pressure, while 17 people with normal blood pressure. Participants diagnosed with hypertension based on JNC 8 were 66%, divided into grade 1, 72.2%, and grade 2, 27.27%. Participants' body mass index was categorized as normal at 24% and obese and/or overweight at 76%. The correlation between blood pressure and obesity was found to be significant (p<0.05). The conclusion that there was a higher rate of participants with hypertension than normal and there was a significant relationship between the risk of hypertension and obesity. Keyword: Blood Pressure, Hypertension, Obese, Body Mass Index, Elderly. ---------------------------------------------------------------------------------------------------------------- Abstrak Hipertensi adalah penyakit degeneratif yang bersifat kronis yang mengenai pembuluh darah. Kasus hipertensi yang dipengaruhi oleh obesitas terus meningkat, tidak hanya di negara maju, tetapi juga menjadi perhatian serius di negara berkembang. Kondisi ini memerlukan strategi baru dalam pengelolaan hipertensi. Pengobatan dengan obat-obatan saja tidak memadai, diperlukan intervensi yang lebih luas untuk mengendalikan tekanan darah, menurunkan berat badan, dan mengubah gaya hidup.Tujuan pengabdian ini adalah untuk meningkatkan perubahan perilaku, sikap dan pencegahan terhadap tekanan darah tinggi dan obesitas sehingga dapat menurunkan angka kesakitan dan kematian akibat komplikasi tekanan darah tinggi. Pengabdian ini dilakukan dengan cara memeriksa tekanan darah peserta, Indeks Massa Tubuh, edukasi serta mengajarkan peserta cara penggunaan tensimeter secara mandiri dirumah untuk mengontrol tekanan darah. Peserta pengabdian yang hadir berjumlah 50 orang. Jangkauan usia peserta adalah 40 hingga 75 tahun dengan peserta lanjut usia berjumlah 42 orang. Rerata usia peserta pengabdian ini adalah 62,75 tahun. Peserta perempuan berjumlah 35 orang sedangkan peserta laki-laki berjumlah 15 orang. Peserta yang terdiagnosa tekanan darah tinggi berjumlah 33 orang sedangkan yang normal berjumlah 17 orang. Peserta yang terdiagnosis hipertensi berdasarkan Joint National Committee (JNC) 8 sebesar 66% terbagi menjadi grade 1 sebanyak 72,2% dan grade 2 sebanyak 27,27%. Indeks massa tubuh peserta dikategorikan normal sebesar 24% dan obesitas dan atau berat badan lebih sebesar 76%. Analisa statistik untuk menentukan korelasi antara tekanan darah menggunakan software JASP 0.19.3. Data tekanan darah dan indeks massa tubuh berdistribusi normal dan menggunakan uji Pearson dengan nilai kemaknaan (p<0,05). Kesimpulan didapatkan bahwa jumlah peserta dengan hipertensi lebih tinggi dibandingkan normal dan terdapat korelasi signifikan antara risiko terjadinya hipertensi dengan normal dan terdapat korelasi signifikan antara risiko terjadinya hipertensi dengan obesitas. Kata kunci: Tekanan darah, Hipertensi, Obesitas, Indeks Massa Tubuh, Lanjut Usia.

Pterigium berhubungan dengan Sindroma Mata Kering pada Pengemudi Ojek Online Kartadinata, Erlani; Amalia, Husnun; Adiwardhani, Anggraeni; Witjaksana, Riani; Prasetyaningsih, Noviani; Margo, Eveline; Yohana, Yohana
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.71-81

Background Dry eye syndrome (DES) is an eye disease caused by many factors involving the ocular surface, with characteristic damage to tear layer homeostasis accompanied by ocular symptoms due to tear layer instability, hyperosmolarity, damage and inflammation of the ocular surface, and neurosensory abnormalities. Delivery motorbike drivers are often on the streets where the role of environmental factors will be able to pose a risk of experiencing DES. This study aims to assess risk factors associated with the incidence of dry eye syndrome in delivery motorbike drivers. The benefit of this research is to improve public health, especially in preventive behavior against factors associated with dry eye syndrome. Methods This study used observational analytical methods with a cross-sectional research design. The selection of samples by consequential non-random sampling amounted to 124 with the criteria of inclusion of delivery motorbike drivers, exclusion of not using artificial tears eye drops, and not use of contact lenses. Data were collected by filling out a DES risk factor questionnaire and a Tear Break Up Time (TBUT) examination to assess DES. The research data were analyzed using the Chi-Square test. Results This study's results show that subjects with dry eye syndrome are dominated by adults aged 19–44 and male sex. Subjects who experienced DES 76.6%, adult age 78.2%, male 80.6%, no pterygium 66.1%, working period 2-5 years 62.9%, length of work ≥8 hours 94.4%, always using a closed helmet 83.9%, not using protective glasses 39.5%, coffee consumption 71.8%, active smokers 66.1%, using gadgets >6 hours 91.9%. There is no significant relationship between subjects' characteristics and DES (p>0.05). The incidence of DES in pterygium showed significant results (p= 0.001). Conclusions There is a significant relationship between the incidence of pterygium and DES.

Gene expression of sirtuin-1 in adult with hypertension Yohana, Yohana; Faradilla, Meutia Atika; Tungka, Endrico Xavierees; Kurniasari, Kurniasari
JPBIO (Jurnal Pendidikan Biologi) Vol 10, No 1 (2025): April 2025
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v10i1.4456

SIRT1 is a key member of the sirtuin family, exerts a unique protective effect on endothelial cells by modulating various proteins, and has a role as an anti-aging biomarker. Hypertension is pathology chronic pathological condition that disrupts ROS and antioxidants. Little evidence showed that sirtuin has a role in chronic oxidative stress. Therefore, the objective of this study was to analyze the relative expression of Sirtuin-1 in hypertension. This is a case-control study with 30 subjects, adults 50-60 years old in each group. JNC 8 was used to determine blood pressure. Quantitative Real Time PCR was used to calculate the level of Sirt-1. The Livak method was used for relative expression. JASP software was used for data analysis. Our study showed Sirtuin-1 mRNA expression was significantly lower in the hypertension group than the normotension group. It was 0.52 fold lower in hypertension. Sirtuin-1 stimulates antioxidants such as superoxide dismutase and catalase through FOXO-dependent signaling. It has a similar role to antioxidants for eliminating ROS. Sirtuin-1 expression is significantly reduced in individuals with hypertension, suggesting its potential role in oxidative stress regulation and its value as a biomarker for vascular aging and hypertension-related endothelial dysfunction.Keyword: Sirtuin-1, hypertension, expression, mRNA

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