Garuda - Garba Rujukan Digital

PENURUNAN BILIRUBIN MENINGKATKAN OKSIDASI LIPOPROTEIN A PADA NEFROPATI DIABETIK Meutia Atika Faradilla; Yahwardiah Siregar; Darwin Dalimunthe
Jurnal Kedokteran Syiah Kuala Vol 17, No 3 (2017): Volume 17 Nomor 3 Desember 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v17i3.9063

ABSTRACT. Diabetic nephropathy is the most common complication of microvascular disease due to diabetes and the third leading cause of renal failure to the end stage. One of the causes of diabetic nephrophaty progression is increase oxidants by lipoprotein a. Bilirubin is a lipophilic endogenous antioxidant that can prevent oxidant effect. This study aims to determine the correlation between bilirubin levels and lipoprotein a in patients with diabetic nephropathy. This research is a case control study with consecutive sampling technique. The subjects were divided into two groups, 25 subjects in the diabetic nephropathy group and 25 subjects in the type 2 diabetes mellitus group without nephropathy. Spearman correlation was used to assess the correlation between bilirubin and lipoprotein a and the mann-whitney test to assess the ratio of bilirubin and lipoprotein a levels in both groups. Antioxidant effect of bilirubin significantly negative correlated with lipoprotein a in the diabetic nephropathy group (r = -0.734; p = 0.000) and also significantly negative correlated in the group of type 2 DM without nephropathy (r = -0.476; p = 0.016). Bilirubin levels in diabetic nephropathy were lower when compared with the group of type 2 DM without nephropathy (OR = 1.3, 95%; CI = 0.23-10.3) whereas lipoprotein a in the diabetic nephropathy group was higher when compared to the type 2 DM group without nephropathy ( OR = 2.8; 95%; CI = 1.84-12.07). Lipoprotein a is a more important risk factor for diabetic nephropathy. Low levels of bilirubin can increase oxidant effect of lipoprotein a and lipoprotein a play a role in progressivity of diabetic nephrophaty.

mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.

Increasing Knowledge About Stunting and Growth Charts Through Seminars and Assistance for Parents of Students Aged 3 – 18 Years Liman, Patricia Budihartanti; Dita Setiati; Yuliana; Faradilla, Meutia Atika; Anastasya, Karina Shasri; Yenny
International Journal of Community Service Learning Vol. 8 No. 4 (2024): November
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/ijcsl.v8i4.79886

Stunting and obesity in Indonesia are still unresolved problems This may be caused by a lack of parental knowledge. StResearch regarding increasing parental knowledge about stunting and the use of growth charts is still controversial. This research aims to determine the effectiveness of health education on parental knowledge. This was a one-group experimental pre- and post-test study involving 61 parents of children aged 3-18 years. A modified structured questionnaire was used to assess stunting knowledge scores through seminars and growth chart knowledge scores through mentoring. Data were analyzed using SPSS ver. 29.0.2.0. The Mann-Whitney test was used to compare changes in scores after the seminar and mentoring training. Post-test knowledge score of seminars and mentoring method improved significantly compared with pretest scores (p < 0.001 for both analyses). The increase in scores for the mentoring method was three times compared to the seminar method (p=0.016). The implication of these findings is that mentoring methods can be considered further on a larger community scale for parent capacity building programs to achieve reduction of malnutrition in Indonesia.

PERAN PENANDA LC3 SEBAGAI FUNGSI AUTOFAGI PADA AGING Xavierees, Endrico; Yohana, Yohana; Faradilla, Meutia Atika; Yastani, Deasyka; Anastasya, Karina Shasri; Suweino, Suweino
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 10, Nomor 1, Januari 2025
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v10i1.21848

Autofagi adalah proses kompleks yang masih perlu diteliti lebih dalam. Proses ini ditandai dengan adanya pembentukan membran oleh peran protein spesifik yang disebut LC3, yang memainkan peran penting dalam mekanisme autofagi. Autofagi adalah bagian penting dari proses metabolisme, karena melibatkan pergerakan organel dari limbah ke autofagosom. Proses ini difasilitasi oleh adanya fagofor dan isolasi membran, yang penting untuk pembentukan autofagosom. Autofagosom kemudian membentuk struktur kompleks dengan lisosom, yang kemudian diubah menjadi autolisosom dan bahan yang terdegradasi. Secara umum juga dikenal dengan makroautofagi namundapat ditemukan jenis lain seperti xenofagi, chaperon-mediated autofagi. Merupakan proses penting dalam menjaga keseimbangan organ-organ internal tubuh, Autofagi juga terlibat dalam pengaturan berbagai proses fisiologis, seperti sekresi insulin, pengaturan gula darah, dan respons imun. Aging mulai dihubungkan dengan autofagi dan masih memiliki banyak ruang yang perlu didalami. Memiliki peran penting dalam aging, kehamilan dan kasus kehamilan lain seperti hambatan pertumbuhan janin, kelahiran preterm, dan Diabetes Gestasional yang banyak ditemukan pada Wanita dengan usia lebih tinggi. Mulai banyak penelitian yang menghubungkan autofagi dengan bertambahnya usia. Hasil Penelitian sebelumnya menunjukkan hubungan erat sehingga mendorong penelitian lebih lanjut untuk menjelaskan fungsi Autofagi pada aging.

Edukasi Penggunaan Tensimeter Digital pada Pemeriksaan Tekanan Darah dengan Status Gizi pada Lansia Kelurahan Angke, Jakarta Barat Yohana; Meiyanti; Margo, Eveline; Atika Faradilla, Meutia; Xavierees, Endrico; Kurniasari
Jurnal Dharma Bhakti Ekuitas Vol. 9 No. 2 (2025): Jurnal Dharma Bhakti Ekuitas
Publisher : Universitas Ekuitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52250/p3m.v9i2.950

Abstract The prevalence of hypertension accompanied by obesity is increasing. This not only happens in developed countries, but is also a problem in developing countries. Hypertension with obesity presents new problems in the management of hypertension. Medical therapy alone is not enough, there must be intervention to reduce and control blood pressure, lose weight and change lifestyle. The aim of this service is to increase public awareness of high blood pressure and obesity so that it can reduce morbidity and death rates due to complications of high blood pressure. This service is carried out by checking participants' blood pressure, Body Mass Index, education and teaching participants how to use a blood pressure monitor independently at home to control blood pressure. There were 50 service participants who attended. The age range of participants is 40 to 75 years with the average age of service participants being 2.75 years. There were 35 female participants while there were 15 male participants. There were 33 participants diagnosed with high blood pressure, while 17 people with normal blood pressure. Participants diagnosed with hypertension based on JNC 8 were 66%, divided into grade 1, 72.2%, and grade 2, 27.27%. Participants' body mass index was categorized as normal at 24% and obese and/or overweight at 76%. The correlation between blood pressure and obesity was found to be significant (p<0.05). The conclusion that there was a higher rate of participants with hypertension than normal and there was a significant relationship between the risk of hypertension and obesity. Keyword: Blood Pressure, Hypertension, Obese, Body Mass Index, Elderly. ---------------------------------------------------------------------------------------------------------------- Abstrak Hipertensi adalah penyakit degeneratif yang bersifat kronis yang mengenai pembuluh darah. Kasus hipertensi yang dipengaruhi oleh obesitas terus meningkat, tidak hanya di negara maju, tetapi juga menjadi perhatian serius di negara berkembang. Kondisi ini memerlukan strategi baru dalam pengelolaan hipertensi. Pengobatan dengan obat-obatan saja tidak memadai, diperlukan intervensi yang lebih luas untuk mengendalikan tekanan darah, menurunkan berat badan, dan mengubah gaya hidup.Tujuan pengabdian ini adalah untuk meningkatkan perubahan perilaku, sikap dan pencegahan terhadap tekanan darah tinggi dan obesitas sehingga dapat menurunkan angka kesakitan dan kematian akibat komplikasi tekanan darah tinggi. Pengabdian ini dilakukan dengan cara memeriksa tekanan darah peserta, Indeks Massa Tubuh, edukasi serta mengajarkan peserta cara penggunaan tensimeter secara mandiri dirumah untuk mengontrol tekanan darah. Peserta pengabdian yang hadir berjumlah 50 orang. Jangkauan usia peserta adalah 40 hingga 75 tahun dengan peserta lanjut usia berjumlah 42 orang. Rerata usia peserta pengabdian ini adalah 62,75 tahun. Peserta perempuan berjumlah 35 orang sedangkan peserta laki-laki berjumlah 15 orang. Peserta yang terdiagnosa tekanan darah tinggi berjumlah 33 orang sedangkan yang normal berjumlah 17 orang. Peserta yang terdiagnosis hipertensi berdasarkan Joint National Committee (JNC) 8 sebesar 66% terbagi menjadi grade 1 sebanyak 72,2% dan grade 2 sebanyak 27,27%. Indeks massa tubuh peserta dikategorikan normal sebesar 24% dan obesitas dan atau berat badan lebih sebesar 76%. Analisa statistik untuk menentukan korelasi antara tekanan darah menggunakan software JASP 0.19.3. Data tekanan darah dan indeks massa tubuh berdistribusi normal dan menggunakan uji Pearson dengan nilai kemaknaan (p<0,05). Kesimpulan didapatkan bahwa jumlah peserta dengan hipertensi lebih tinggi dibandingkan normal dan terdapat korelasi signifikan antara risiko terjadinya hipertensi dengan normal dan terdapat korelasi signifikan antara risiko terjadinya hipertensi dengan obesitas. Kata kunci: Tekanan darah, Hipertensi, Obesitas, Indeks Massa Tubuh, Lanjut Usia.

Gene expression of sirtuin-1 in adult with hypertension Yohana, Yohana; Faradilla, Meutia Atika; Tungka, Endrico Xavierees; Kurniasari, Kurniasari
JPBIO (Jurnal Pendidikan Biologi) Vol 10, No 1 (2025): April 2025
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v10i1.4456

SIRT1 is a key member of the sirtuin family, exerts a unique protective effect on endothelial cells by modulating various proteins, and has a role as an anti-aging biomarker. Hypertension is pathology chronic pathological condition that disrupts ROS and antioxidants. Little evidence showed that sirtuin has a role in chronic oxidative stress. Therefore, the objective of this study was to analyze the relative expression of Sirtuin-1 in hypertension. This is a case-control study with 30 subjects, adults 50-60 years old in each group. JNC 8 was used to determine blood pressure. Quantitative Real Time PCR was used to calculate the level of Sirt-1. The Livak method was used for relative expression. JASP software was used for data analysis. Our study showed Sirtuin-1 mRNA expression was significantly lower in the hypertension group than the normotension group. It was 0.52 fold lower in hypertension. Sirtuin-1 stimulates antioxidants such as superoxide dismutase and catalase through FOXO-dependent signaling. It has a similar role to antioxidants for eliminating ROS. Sirtuin-1 expression is significantly reduced in individuals with hypertension, suggesting its potential role in oxidative stress regulation and its value as a biomarker for vascular aging and hypertension-related endothelial dysfunction.Keyword: Sirtuin-1, hypertension, expression, mRNA

mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.

Hubungan Profil Lipid dan Kejadian Migren pada Karyawan di Jakarta Satyasari, Daniella; Larasari, Andira; Faradilla, Meutia Atika; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 1 (2025): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i1.14885

One of the risk factor for migraines is an elevated lipid profile. The most significant of the primary lipoproteins that causes atherosclerosis and readily binds to blood vessel walls is LDL. Because lipoprotein A (Lp(a)) levels have an atherogenic ApoA structure, increasing oxidative stress and fat oxidation can lead to endogenous vascular injury. Cross-sectional design was used to perform this study from October 2023 to June 2024 in Universitas Trisakti, Faculty of Medicine. The purpose of this study is to evaluate the association between the lipid level and the incidence of migraines among employees in Jakarta. The target population consists of Jakarta's private employees. With a total sample size of 66 employees that meet the inclusion and exclusion criteria, the study sample will be drawn using the sequential sampling method. The study's findings highlighted that high LDL (p=0.002) and total cholesterol (p=0.0001) had a significant relationship with migraines, whereas HDL, triglycerides, and Lp(a) had an insignificant link with the incidence of migraine (p>0.05). The study concluded that LDL is a powerful predictor of migraine occurrence and has a significant association with migraine.

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