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Application of the Simplex Lattice Design Method to Determine the Optimal Formula of Diclofenac Sodium Nanoemulsion Nahdhia, Nadhifatun; M. Agus Syamsur Rijal; Esti Hendradi; Riyanto Teguh Widodo
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.137-146

Abstract

Background: The success of nanoemulsion preparation, with the aim of producing good characteristic values, is determined by the ratio of each component. The design of experiments (DoE) approach using the Simplex Lattice Design (SLD) method can be used to determine the optimal formula for nanoemulsions, with variable factors consisting of oleic acid, Tween 20:ethanol (4:1), and water. The observed response variables included droplet size, PDI, and pH. Objective: DoE can help reduce the energy, cost, and time needed to make the optimal formula for diclofenac sodium nanoemulsions. Methods: Nanoemulsions were prepared using low-energy emulsification. Their characteristics were evaluated and analyzed using Design Expert software. Results: The optimal nanoemulsion formulation consisted of 4.17% oleic acid, 37.5% emulsifier (Tween 20: ethanol, 4:1), and 58.33% water. The nanoemulsion characteristics were good, with 20.37 a droplet size, 0.42 PDI, of 4.75 pH. The observed values were not significantly different from the predicted values, and the formula could effectively trap 1% diclofenac sodium. Conclusion: The simplex lattice design method is very useful for pharmaceutical development, such as nanoemulsion optimization.
Pemberdayaan Perempuan dalam Upaya Meningkatkan Kualitas Kesehatan Masyarakat melalui Pemahaman Bentuk Sediaan, Kemasan, Keamanan dan Stabilitas Obat di Kabupaten Magetan untuk Mendukung SDG’s 3 Sari, Retno; M. Agus Syamsur Rijal; Andang Miatmoko; Dini Retnowati; Dewi Isadiartuti; , Idha Kusumawati; Noorma Rosita; Tutik Sri Wahyuni
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol. 11 No. 2 (2026): JURNAL ABDI : Media Pengabdian Kepada masyarakat
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/abdi.v11i2.44377

Abstract

Abstract Health is a condition of physical, mental, spiritual, and social prosperity that allows a person to live a productive life (Law No. 36/2009). Knowledge of drugs is important for the public to avoid the use of counterfeit and illegal drugs, which according to the WHO includes drugs without active ingredients, different ingredients, or with strength that does not match the label. The Community Service Program has been carried out to increase public knowledge, primarily through the role of women, about the dosage form, packaging, safety, and stability of drugs. The activity was carried out using a lecture and discussion method and involved 45 participants from 17 women's organizations in the Magetan area. The results showed that this program succeeded in increasing participants' understanding of drug dosage form, packaging, safety, and stability. This activity also received a positive response from the participants and was reported by local media. The community service program successfully increased the community's knowledge and understanding of drugs and drug stability, thus strengthening SDGs 3. Keywords: Health, medicine, safety, stability, SDGs 3