Article Per Year (5 Year)
p-Index From 2020 - 2025
0.751
P-Index
This Author published in this journals
All Journal Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Eksis: Jurnal Ilmiah Ekonomi dan Bisnis Hydrogen: Jurnal Kependidikan Kimia
Rahmadani, Indah
Unknown Affiliation
Chemistry Economics, Econometrics & Finance Education

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Cytotoxic Potensial and Molecular Docking of Essential Oil Piper Aduncum Flowers Against Cervical Cancer Cells Rahmadani, Indah; Efdi, Mai; Suryati, Suryati
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 4 (2024): August 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i4.12479

Abstract

Piper aduncum L., commonly known as spiked pepper, is a medicinal plant traditionally used to treat various diseases due to its diverse, active compounds. This article investigates the chemical composition, cytotoxic bioactivity in vitro and the silico of the essential oil (EO) from the flowers of Piper aduncum collected in Padang City, Indonesia. The EO was obtained by hydrodistillation using a Clevenger-type apparatus and characterized by gas chromatography-mass spectrometry (GC-MS). The in vitro cytotoxicity of the EO was assessed against cervical cancer (HeLa cancer cell line) using the MTT assay and further explored through molecular docking approaches. The main constituent of the essential oil from the flowers was dillapiol (31.68%). The LC50 and IC50 values were 31.3471 µg/mL and 65.83 µg/mL, respectively. Computational screening was performed to observe the interactions between active compounds and proteins AKT and ERK2 using molecular docking. AKT and ERK2 act as critical regulators in the PI3K/Akt and ERK/MEK signaling pathways and are potential drug targets for cancer therapy. The compounds used complied with ADMET analysis and toxicity profile. However, it is noteworthy that there have been no previous reports on the essential oil from Piper aduncum flowers from Padang City specifically targeting cervical cancer, which molecular docking studies have complemented. The results suggest that the essential oil from the flowers of Piper aduncum can be further studied as a potential lead in drug discovery for cervical cancer.
Pengaruh Pertumbuhan Ekonomi, Upah Minimum Provinsi dan Tingkat Pendidikan terhadap Tingkat Partisipasi Angkatan Kerja di Provinsi Jambi Tahun 2009-2023 Fathiyah, Fathiyah; Syukri, Muhammad; Masnun, Masnun; Rahmadani, Indah
Eksis: Jurnal Ilmiah Ekonomi dan Bisnis Vol 15, No 2 (2024): November
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/eksis.v15i2.463

Abstract

The purpose of this study is to determine the effect of economic growth, provincial minimum wage, and education level simultaneously and partially on the Labor Force Partippcipation Rate in Jambi Province in 2009-2023. The data used in this study is secondary data published in the form of a time series for 15 years starting from 2009-2023 in Jambi Province. The source of data obtained from the agency is the Central Statistic Agency (BPS) in Jambi Province. This study used multiple linear regression analysis tools, and data analysis prerequisite test using normality, multicollinearity, autocorrelation, and heteroscedasticity tests. The hypothesis test used are the coefficients of determination (R2), F test and T test. The result of this study show simultaneously that: Economic Growth, Provincial Minimum Wage, and Education Level do not affect the Labor Force Participation Rate in Jambi Province in 2009-2023. And Partially : (1) Economic Growth does not affect the Lbor Force Participation Rate, (2) The Provincial Minimum Wage does not affect the Labor Force Participation Rate. (3) The Level of Education does not affect the Labor Force Participation Rate in Jambi Province 2009- 2023.
Eligibility of E-Module Biology Material Cell-Assisted Flipping Book Mellisa, Mellisa; Saputri, Delma; Rahmadani, Indah
Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Vol 15 No 1 (2025): Bioeduin: Februari
Publisher : Department of Biology Education UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/bioeduin.v15i1.43643

Abstract

This study aims to produce an e-module of biology teaching materials based on flipping books on cell material for grade XI high school. This study is a research and development (R&D) research with the ADDIE model (analysis, design, development, implementation, and evaluation), but it is limited to the development stage. This e-module is made using the flipping book application. The sampling technique in this study is purposive sampling. The sample used in this study was 45 high school students. The results of this study indicate that the quality of the validity of the e-module of teaching materials based on the results of the Validation of learning experts falls into the very valid category with an average of 99.06% (very valid), the results of the Validation of material experts get an average of 94.44% (very valid), the results of the Validation of media experts get an average of 92.98% (very valid), and the results of the Validation by three biology teachers get an average percentage of 95.55% (very valid). The trial results showed that students earned an average of 92.07% (very good); based on several categories, the developed e-module of learning is very valid and can be used as teaching materials to help students' learning process.
Cytotoxic Potensial and Molecular Docking of Essential Oil Piper Aduncum Flowers Against Cervical Cancer Cells Rahmadani, Indah; Efdi, Mai; Suryati, Suryati
Hydrogen: Jurnal Kependidikan Kimia Vol. 12 No. 4 (2024): August 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i4.12479

Abstract

Piper aduncum L., commonly known as spiked pepper, is a medicinal plant traditionally used to treat various diseases due to its diverse, active compounds. This article investigates the chemical composition, cytotoxic bioactivity in vitro and the silico of the essential oil (EO) from the flowers of Piper aduncum collected in Padang City, Indonesia. The EO was obtained by hydrodistillation using a Clevenger-type apparatus and characterized by gas chromatography-mass spectrometry (GC-MS). The in vitro cytotoxicity of the EO was assessed against cervical cancer (HeLa cancer cell line) using the MTT assay and further explored through molecular docking approaches. The main constituent of the essential oil from the flowers was dillapiol (31.68%). The LC50 and IC50 values were 31.3471 µg/mL and 65.83 µg/mL, respectively. Computational screening was performed to observe the interactions between active compounds and proteins AKT and ERK2 using molecular docking. AKT and ERK2 act as critical regulators in the PI3K/Akt and ERK/MEK signaling pathways and are potential drug targets for cancer therapy. The compounds used complied with ADMET analysis and toxicity profile. However, it is noteworthy that there have been no previous reports on the essential oil from Piper aduncum flowers from Padang City specifically targeting cervical cancer, which molecular docking studies have complemented. The results suggest that the essential oil from the flowers of Piper aduncum can be further studied as a potential lead in drug discovery for cervical cancer.
Co-Authors Fathiyah Fathiyah Mai Efdi Masnun Masnun Mellisa, Mellisa Muhammad Syukri saputri, delma Suryati Suryati