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All Journal Jurnal Biologi dan Pembelajarannya (JBP) Biology, Medicine, & Natural Product Chemistry KOPEMAS
Gatra Ervi Jayanti
Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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METODE PEMBELAJARAN KONSEP BIOLOGI MOLEKULER MELALUI PENDEKATAN IN SILICO DI SMA DIPONEGORO, NEGARA, BALI Gatra Ervi Jayanti; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) 2020
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kemajuan teknologi yang pesat akan membawa pengaruh terhadap kehidupan. Penggunaan teknologi yang tepat akan memudahkan aktivitas manusia, contohnya dalam bidang pendidikan. Pendidikan dapat diakses dengan mudah melalui komputer, laptop dan ponsel pintar. Berbagai bidang ilmu memanfaatkan kecanggihan teknologi, salah satu contohnya adalah Biologi. Ilmu Biologi menggunakan perangkat lunak untuk permodelan, dan prediksi, yang biasa disebut in silico. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk mengenalkan ilmu Biomolekuler secara sederhana dan aplikasinya melalui pendekatan in silico pada siswa SMA. Metode pelaksanaan kegiatan ini dengan menjelaskan materi tentang in silico dan penerapannya dalam kehidupan, serta diadakan tanya jawab. Hasil dari pengabdian ini terlihat dari tanggapan positif dan antusias siswa.  
Analysis of the Antioxidant Activity of Young and Mature Bidara Leaves Using 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) and Phytochemical Screening Test Alvelin Bunga Kurniawati; Gatra Ervi Jayanti; Majida Ramadhan; Dian Novita Wulandari; Ike Widyaningrum
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1257-1263

Abstract

This study aimed to compare the antioxidant activity of young and mature bidara leaves using the DPPH method and to identify the content of secondary metabolites through phytochemical testing. Antioxidant activity was measured using the IC50 parameter, which represents the concentration of the extract that can capture 50% of DPPH free radicals. The test results showed that mature bidara leaves had an IC50 value of 34.984 ppm, indicating vigorous antioxidant activity, while young leaves had an IC50 value of 100.327 ppm, classified as moderate activity. Phytochemical testing revealed that both types of leaves contained alkaloids, saponins, and tannins, while flavonoids and triterpenoids were only found in old leaves. These results suggest that variations in secondary metabolite content, influenced by leaf age, contribute to differences in antioxidant activity. Thus, older bidara leaves are more potent as an antioxidant source compared to younger leaves. This study supports the utilization of bidara plants in the pharmaceutical industry and the development of traditional medicine based on natural ingredients.
In silico and Histochemical Analysis of Soursop Leaves (Annona muricata) Against Alpha Estrogen Receptor Afidah Fajar Nuari; Gatra Ervi Jayanti; Majida Ramadhan
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1055-1068

Abstract

Soursop leaves (Annona muricata) are known as a plant that has the potential to treat breast cancer, which has a high mortality rate in women in Indonesia. The receptor that plays the most important role in breast cancer development is the Estrogen Receptor Alpha (ERa). This study aims to identify active compounds in soursop leaves that have the potential to inhibit breast cancer cell growth through in silico analysis using molecular docking of the ER? receptor using KNApSAck, PASS Online, PubChem, PDB ID, PyRx, and Discovery Studio software and Histochemical analysis was performed using fresh soursop leaves by making an incision on the lower part of the leaf and adding reagents AlCl, FeCl, Na2CO, CuSO4, glycerin, Wagner reagent, immersion oil, and ethanol, then observed microscopically. The in silico results showed the presence of specific compounds from soursop leaves and one reference compound (OHT600). Cis-Solamin had the highest binding affinity (-9.3 kcal/mol), better than the native ligand (-7.6 kcal/mol), and interacted with the amino acid Glutamine 532 (GLU532). Histochemical analysis showed the content of flavonoids, phenols, tannins, terpenoids, and alkaloids, accompanied by color changes in trichome and stomatal tissues. Based on the research data, it was concluded that soursop leaves can inhibit the growth of breast cancer cells through the content of secondary metabolites that actively inhibit Er? receptors.
Antibacterial Innovation of Iron Nanoparticles from Pomegranate Peel Extract (Punica granatum L.): an In Vitro Study Shofia Jannatul Ma'rifah; Nur Azizah; Zahrotul Jamilah; Thoifatus Syarivah; Nabiilah Rifda Harmono Putri; Majida Ramadhan; Gatra Ervi Jayanti
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.245-252

Abstract

Iron nanoparticles (Fe-NPs) were synthesized from pomegranate peel extract using ethanol as a solvent. The antibacterial activity of the synthesized Fe-NPs against pathogenic bacteria (S. aureus and E. coli) was assessed using the well diffusion method. The morphology, structure, size, and atomic distribution on the surface of Fe-NPs were characterized using SEM-EDS, UV-Vis, and FTIR spectroscopy. Different pH conditions (5, 7, and 9) were investigated as experimental factors for Fe-NPs preparation. The results revealed mostly irregular spherical shapes with particle sizes ranging from 1 to 89 nm, with the smallest size observed at pH 9. UV-Vis spectra confirmed the formation of Fe-NPs, appearing in the UV region around 230-295 nm. FTIR spectra indicated the presence of polyphenolic compounds from the pomegranate peel extract, which facilitated Fe-NPs stabilization and acted as bioreductants. Upon reduction of Fe(III) to Fe(0), oxidation of O-H and C-O functional groups occurred. The diameters of inhibition zones against the tested bacteria were 16 mm at pH 5, 13 mm at pH 7, and 15 mm at pH 9, indicating strong antibacterial activity.
Pengaruh Gas Etilen Tomat (Solanum lycopersicum) terhadap Pertumbuhan Tanaman Kacang Hijau (Vigna radiata L.) Nur Azizah; Shofia Jannatul Ma'rifah; Zahrotul Jamilah; Dewi Astriana Safitri; Gatra Ervi Jayanti; Majida Ramadhan; Eka Prasetyowati
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 12 No 2 (2025): OKTOBER 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v12i2.25867

Abstract

Kacang hijau (Vigna radiata L.) termasuk ke dalam suku polong-polongan yang mengandung bahan baku berprotein nabati tinggi. Pertumbuhan tanaman kacang hijau dapat dipengaruhi oleh pemberian hormon termasuk hormon etilen yang dapat diperoleh secara alami dari buah. Penelitian ini bertujuan untuk mengetahui pengaruh dari gas etilen alami yang dihasilkan oleh buah tomat (Solanum lycopersicum) terhadap pertumbuhan tanaman kacang hijau (Vigna radiata L.). Gas etilen merupakan hormon tumbuhan berbentuk gas yang berperan dalam proses pematangan dan penuaan, namun pada fase awal pertumbuhan tanaman, gas ini dapat memengaruhi proses perkecambahan dan perkembangan vegetatif. Penelitian dilakukan secara eksperimental selama tujuh hari di Laboratorium Orchidologi Universitas Islam Malang, dengan menggunakan empat perlakuan, yaitu satu kontrol (tanpa tomat) dan tiga perlakuan dengan penambahan tomat. Parameter yang diamati meliputi tinggi batang, bentuk batang, jumlah daun, dan kondisi akar. Hasil penelitian menunjukkan bahwa perlakuan gas etilen dari tomat menghambat pertumbuhan tanaman kacang hijau. Tanaman yang diberi perlakuan menunjukkan batang tinggi lebih pendek, bentuk batang yang tebal dan kerdil, serta jumlah daun lebih sedikit dibandingkan dengan kontrol. Meskipun akar tetap tumbuh lebat, perkembangan tanaman secara keseluruhan terganggu. Kesimpulannya, gas etilen dari tomat memiliki pengaruh negatif terhadap pertumbuhan awal tanaman kacang hijau, khususnya dalam fase perkecambahan dan pertumbuhan batang serta daun    
Co-Authors Afidah Fajar Nuari Alvelin Bunga Kurniawati Dewi Astriana Safitri Dian Novita Wulandari Eka Prasetyowati Ike Widyaningrum Majida Ramadhan Nabiilah Rifda Harmono Putri Nour Athiroh Abdoes Sjakoer Nur Azizah Nurul Jadid Mubarokati Shofia Jannatul Ma'rifah Thoifatus Syarivah Zahrotul Jamilah