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All Journal Biology, Medicine, & Natural Product Chemistry KOPEMAS
Gatra Ervi Jayanti
Universitas Islam Malang
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health Social Sciences

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METODE PEMBELAJARAN KONSEP BIOLOGI MOLEKULER MELALUI PENDEKATAN IN SILICO DI SMA DIPONEGORO, NEGARA, BALI Gatra Ervi Jayanti; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) 2020
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

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Abstract

Kemajuan teknologi yang pesat akan membawa pengaruh terhadap kehidupan. Penggunaan teknologi yang tepat akan memudahkan aktivitas manusia, contohnya dalam bidang pendidikan. Pendidikan dapat diakses dengan mudah melalui komputer, laptop dan ponsel pintar. Berbagai bidang ilmu memanfaatkan kecanggihan teknologi, salah satu contohnya adalah Biologi. Ilmu Biologi menggunakan perangkat lunak untuk permodelan, dan prediksi, yang biasa disebut in silico. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk mengenalkan ilmu Biomolekuler secara sederhana dan aplikasinya melalui pendekatan in silico pada siswa SMA. Metode pelaksanaan kegiatan ini dengan menjelaskan materi tentang in silico dan penerapannya dalam kehidupan, serta diadakan tanya jawab. Hasil dari pengabdian ini terlihat dari tanggapan positif dan antusias siswa.  
Analysis of the Antioxidant Activity of Young and Mature Bidara Leaves Using 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) and Phytochemical Screening Test Alvelin Bunga Kurniawati; Gatra Ervi Jayanti; Majida Ramadhan; Dian Novita Wulandari; Ike Widyaningrum
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1257-1263

Abstract

This study aimed to compare the antioxidant activity of young and mature bidara leaves using the DPPH method and to identify the content of secondary metabolites through phytochemical testing. Antioxidant activity was measured using the IC50 parameter, which represents the concentration of the extract that can capture 50% of DPPH free radicals. The test results showed that mature bidara leaves had an IC50 value of 34.984 ppm, indicating vigorous antioxidant activity, while young leaves had an IC50 value of 100.327 ppm, classified as moderate activity. Phytochemical testing revealed that both types of leaves contained alkaloids, saponins, and tannins, while flavonoids and triterpenoids were only found in old leaves. These results suggest that variations in secondary metabolite content, influenced by leaf age, contribute to differences in antioxidant activity. Thus, older bidara leaves are more potent as an antioxidant source compared to younger leaves. This study supports the utilization of bidara plants in the pharmaceutical industry and the development of traditional medicine based on natural ingredients.
In silico and Histochemical Analysis of Soursop Leaves (Annona muricata) Against Alpha Estrogen Receptor Afidah Fajar Nuari; Gatra Ervi Jayanti; Majida Ramadhan
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1055-1068

Abstract

Soursop leaves (Annona muricata) are known as a plant that has the potential to treat breast cancer, which has a high mortality rate in women in Indonesia. The receptor that plays the most important role in breast cancer development is the Estrogen Receptor Alpha (ERa). This study aims to identify active compounds in soursop leaves that have the potential to inhibit breast cancer cell growth through in silico analysis using molecular docking of the ER? receptor using KNApSAck, PASS Online, PubChem, PDB ID, PyRx, and Discovery Studio software and Histochemical analysis was performed using fresh soursop leaves by making an incision on the lower part of the leaf and adding reagents AlCl, FeCl, Na2CO, CuSO4, glycerin, Wagner reagent, immersion oil, and ethanol, then observed microscopically. The in silico results showed the presence of specific compounds from soursop leaves and one reference compound (OHT600). Cis-Solamin had the highest binding affinity (-9.3 kcal/mol), better than the native ligand (-7.6 kcal/mol), and interacted with the amino acid Glutamine 532 (GLU532). Histochemical analysis showed the content of flavonoids, phenols, tannins, terpenoids, and alkaloids, accompanied by color changes in trichome and stomatal tissues. Based on the research data, it was concluded that soursop leaves can inhibit the growth of breast cancer cells through the content of secondary metabolites that actively inhibit Er? receptors.
Co-Authors Afidah Fajar Nuari Alvelin Bunga Kurniawati Dian Novita Wulandari Ike Widyaningrum Majida Ramadhan Nour Athiroh Abdoes Sjakoer Nurul Jadid Mubarokati