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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Kajian dan Inovasi Ilmu (JKII) Journal of Advanced Pharmaceutical Research Sciences and Sustainability
Ratna Mildawati
Stikes Ganesha Husada
Humanities Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Other

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Study of High Potential for Addiction Group 1 Psychotropic Drugs Used in Science Yuneka Saristiana; Fendy Prasetyawan; Ratna Mildawati; Chandra Arifin; Faisal Akhmal Muslikh; Abd Rofiq; Widhi Astutik
Journal of Advanced Pharmaceutical Research Sciences and Sustainability (JAPRSS) Vol. 2 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/japrss.v1i2.1237

Abstract

Background. Research on high-potential addiction psychotropic drugs from Group 1 is an essential undertaking in the fields of pharmacology and mental health treatment, requiring an extensive introduction to provide context and delineate its importance and breadth. Purpose. This study offers a comprehensive examination of Group 1 psychotropic drugs, emphasizing their pharmacological characteristics, addictive tendencies, and regulatory implications Method. Drawing upon data extracted from Indonesian Ministry of Health Regulation No. 10 of 2022, the research compiles and delineates the psychotropic drugs falling under Group 1 classification. Results. Drugs name as Deskloro ketamin, 2F- Deskloro ketamin, Flubroma zolam, Flualpra zolam, Klonazolam are identified, each presenting distinct pharmacological effects and addiction potentials. The study highlights the imperative for stringent regulatory measures owing to the pronounced likelihood of abuse and adverse consequences associated with these substances. Regulatory frameworks must remain dynamic to effectively address emerging challenges and evolving patterns of drug usage. Conclusion. This research significantly contributes to the comprehension of psychotropic drugs and informs strategies aimed at ensuring their judicious and safe utilization.
Chemical Structure Profile and Computational Descriptors of Fenbufen Butanamine by PubChem Yuneka Saristiana; Fendy Prasetyawan; Ratna Mildawati; Yogi Bhakti Marhenta; Eka Hayati Rhomah; Mujtahid Bin Abd Kadir
Jurnal Kajian dan Inovasi Ilmu (JKII) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/jkii.v1.i2.2

Abstract

Fenbufen Butanamine is a structural derivative of the non-steroidal anti-inflammatory drug (NSAID) Fenbufen, characterized by the addition of a butanamine group to its core structure. This modification is intended to improve the pharmacokinetic and pharmacodynamic properties of the parent compound, potentially enhancing its therapeutic efficacy. In this study, we conducted a detailed computational analysis of Fenbufen Butanamine’s chemical structure and molecular descriptors using data retrieved from the PubChem database. The chemical identity was confirmed by its IUPAC name, InChI, InChIKey, and SMILES notation, which provide precise molecular characterization essential for database referencing and further computational modeling. Key computational descriptors, such as molecular weight, logP, topological polar surface area (TPSA), and the count of hydrogen bond donors and acceptors, were analyzed to assess drug-likeness and predict pharmacokinetic behavior. Our findings indicate that Fenbufen Butanamine possesses a biphenyl core that contributes to hydrophobic interactions, while the butanamine side chain introduces hydrophilic properties. This amphiphilic nature is likely to influence the compound’s solubility, membrane permeability, and binding affinity to biological targets. The computed descriptors suggest favorable properties for oral bioavailability and potential interactions within biological systems. These results serve as a foundational step for in silico drug design and optimization of Fenbufen derivatives. Further experimental and pharmacological studies are warranted to validate these computational predictions and explore the therapeutic potential of Fenbufen Butanamine. 
Uji Aktivitas Antipembekuan Darah dan Docking dari Daun Kaki Unta (Waltheria indica L.) Pertiwi Awilda; Bawaihi Bawaihi; Muhammad Jayyid Jiddan; Ratna Mildawati; Samsul Hadi
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.31402

Abstract

Di Indonesia, prevalensi penyakit jantung koroner (PJK) adalah 1,5% di semua kelompok umur, sehingga masih menjadi masalah serius. Jika berbicara tentang penyakit kardiovaskular, PJK berada di urutan teratas. Tujuan dari penelitian ini adalah uji aktivitas W. indica berkaitan dengan kemampuan sebagai antikoagulan. Darah tikus digunakan untuk teknik pengujian in vitro, sedangkan waktu pendarahan tikus diukur untuk pengujian in vivo, dengan menggunakan perangkat lunak PLANT dalam docking, penelitian insilico digunakan untuk mengidentifikasi senyawa dari W. indica yang mungkin memiliki sifat antikoagulan, Discovery Studio kemudian digunakan untuk mengidentifikasi residu yang terlibat dalam interaksi dan skor doking digunakan dalam analisis data. Hasil uji in vitro untuk ekstrak etanol menunjukkan adanya koagulasi pada menit ke-30, fraksi n-heksana pada menit ke-10, fraksi etil asetat dan n-butanol pada menit ke-60, dan pada uji in vivo pendarahan hingga 349 ± 23 detik untuk dosis 100 mg/kg BB, 425 ± 27 detik untuk dosis 200 mg/kg BB, dan 546 ± 34 detik untuk dosis 300 mg/kg BB, hal ini lebih baik dari pada kontrol, dan dengan docking mengungkapkan bahwa senyawa yang berpotensi dalam  pengujian ini adalah quercetin. Kesimpulannnya  W. indica  berpotensi sebagai antipembekuan  darah
Co-Authors Abd Rofiq Bawaihi Bawaihi Chandra Arifin Eka Hayati Rhomah Faisal Akhmal Muslikh Fendy Prasetyawan Muhammad Jayyid Jiddan Mujtahid Bin Abd Kadir Pertiwi Awilda Samsul Hadi Widhi Astutik Yogi Bhakti Marhenta Yuneka Saristiana