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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Journal of Social Research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Cermin Dunia Kedokteran
Endra Yustin Ellistasari
Bagian Ilmu Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran, Universitas Sebelas Maret Surakarta/RSUD Dr. Moewardi, Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Kombinasi Krioterapi dan KOH 5% untuk Terapi Kondiloma Akuminata Raksasa dengan Infeksi HIV Rini Hastuti; Etty Farida Mustifah; Endra Yustin Ellistasari
Cermin Dunia Kedokteran Vol 45 No 7 (2018): Onkologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.753

Abstract

Pendahuluan. Kondiloma akuminata raksasa (KAR) atau disebut juga tumor Buschke-Lowenstein adalah tumor akibat infeksi human papillomavirus (HPV) di daerah anorektal dan genitalia eksterna dengan diameter lebih dari 2,5 cm. Kasus. Seorang laki-laki homoseksual, 32 tahun dengan benjolan yang bertambah banyak dan makin membesar sejak 2 bulan. Pasien terinfeksi HIV sejak 2 tahun yang lalu. Kombinasi krioterapi dan larutan KOH 5% memberikan perbaikan klinis. Diskusi. Terapi kombinasi dapat dijadikan pilihan terapi KAR disertai penyulit atau jika terapi tunggal tidak memberikan perbaikan klinis.   Background. Giant condyloma acuminata also known as Buschke-Lowenstein tumor is a tumor caused by human papillomavirus (HPV) infection in anorectal area and external genitalia with diameter more than 2.5 cm. Case. A 32 year old homosexual male had multiplying and growing lumps since two months. Patient was diagnosed HIV since 2 years ago. A combination therapy with cryotherapy and KOH 5% solution resulted in clinical improvement. Discussion. Combination therapy may be an option for giant condyloma acuminata with complications or if single therapy does not provide clinical improvement.
Basal Cell Carcinoma Type Based on Histopathological Examination: Aggressive vs. Non-Aggressive Fanny Fauziyyah Heryadi; Nugrohoaji Dharmawan; Prasetyadi Mawardi; Endra Yustin Ellistasari
Jurnal Penelitian Pendidikan IPA Vol 11 No 11 (2025): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i11.13073

Abstract

Histopathological subtypes of basal cell carcinoma (BCC) help determine prognosis and guide management. This study aimed to describe and compare the clinical and histopathological characteristics of aggressive and nonaggressive BCC. An observational descriptive study was conducted on 26 patients with biopsy-proven BCC. Hematoxylin and eosin (H&E) –stained sections were reviewed by an experienced pathologist. The nonaggressive group included nodular and superficial BCC, while the aggressive group included infiltrative and morpheaform BCC. Clinical and demographic data were recorded, and representative images were selected. Of the 26 cases, 13 were classified as aggressive and 13 as nonaggressive BCC. Female predominance was observed in both groups (61.54% vs. 69.24%). The mean age was 62.08 years in the aggressive group and 69.23 years in the nonaggressive group. Lesions were most frequently located in the nasal and zygomatic regions. The nodular subtype predominated among nonaggressive BCC (76.92%), while infiltrative (53.85%) and morpheaform (46.15%) subtypes were most common in the aggressive group. Histologically, nonaggressive subtypes exhibited well-circumscribed basaloid nests with palisading, whereas aggressive subtypes showed irregular cords within desmoplastic stroma and ill-defined margins. Histopathological examination remains the gold standard for differentiating aggressive from nonaggressive BCC, providing essential guidance for surgical planning and recurrence prevention.
Topical Polypeptide Gel in Diabetic Ulcers: Clinical Insights Into a New Adjunctive Treatment Modality Stella Gracia Octarica; Suci Widhiati; Endra Yustin Ellistasari; Nugrohoaji Dharmawan; Indah Julianto
Journal of Social Research Vol. 4 No. 10 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i9.2794

Abstract

Diabetic ulcers are a common and challenging complication of diabetes, contributing to morbidity, infection, and a high risk of amputation. Innovative adjuncts, such as topical polypeptide gel, which contains amino acids to support tissue regeneration, are proposed to accelerate wound healing; however, supporting clinical data are limited. A quasi-experimental analysis was conducted in 11 patients. Each received a daily topical 7% polypeptide gel in addition to standard care. Ulcer area was measured at baseline (day 0) and after 14 days using digital documentation analysis using ImageJ. The primary outcome was the percentage reduction in ulcer size. Patients were analysed for associations between percentage of improvement with age, gender, diabetes type, and ulcer site. Eleven patients with diabetic ulcers completed the 14-day treatment protocol. The cohort comprised 54.5% females with a mean age of 54.1 ± 7.3 years and predominantly insulin-dependent diabetes (72.7%). Baseline ulcer area averaged 982.1 ± 1315.1 mm², reducing to 184.0 ± 297.7 mm² by day 14, representing an 86.2 ± 6.7% mean area reduction. All patients achieved ?76% healing, with 45.5% achieving ?90% area reduction and 9.1% achieving complete healing. The Wilcoxon signed-rank test demonstrated statistically significant ulcer area reduction (Z = -2.934, p = 0.003). No significant associations were found between healing percentage and patient demographics, diabetes type, ulcer location, or comorbidity burden (all p > 0.05). No treatment-related adverse events were reported during the study period. Topical polypeptide gel demonstrated rapid wound surface area reduction in the majority of the subjects over 14 days, independent of patient age, gender, diabetes type, or ulcer location. These findings suggest its promise as an adjunctive early-phase therapy for diabetic ulcers.
Evaluating the Serofast State in Syphilis: A Study of Clinical Characteristics, Immunological Markers, and HIV Status Lifesia Natali Lidjaja; Endra Yustin Ellistasari; Muhammad Eko Irawanto; Arie Kusumawardani; Nurrachmat Mulianto
Journal of Social Research Vol. 5 No. 4 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i4.3097

Abstract

Syphilis remains a significant global health burden, particularly among high-risk populations such as men who have sex with men (MSM). A major challenge in management is the serofast state, where patients fail to achieve serological cure despite adequate treatment. The immunological mechanisms driving this, especially in the context of HIV co-infection, remain unclear. This study aims to evaluate clinical and immunological factors associated with serofast status versus serological cure. A retrospective cohort study was conducted on 40 patients diagnosed with syphilis (early latent, late latent, or secondary). Data on demographics, HIV status, CD4/CD8 counts, and pre- and post-treatment VDRL titers were analyzed. Bivariate and multivariate logistic regression analyses were performed to identify predictors of the serofast outcome. The cohort was predominantly males (90.0%) and unmarried (80.0%). HIV co-infection was identified as the sole independent predictor of the serofast state (aOR = 10.94; 95% CI: 1.72-69.65; p=0.011). While post-treatment VDRL titers significantly decreased in the total cohort, the serofast group retained significantly higher antibody levels compared to the serological cure group (p<0.001). However, no statistically significant differences were found in CD4 counts, CD8 counts, or CD4/CD8 ratios between the two groups. HIV co-infection is a strong predictor of the serofast state in syphilis patients. The lack of significant differences in quantitative cellular immune markers suggests that the persistence of antibodies may be driven by functional immune dysregulation rather than absolute T-cell depletion. These findings emphasize the need for vigilant serological monitoring in HIV-syphilis co-infected individuals.
The Effect of Oral Bromelain on Interleukin-6 Levels in Tissue of Acne Vulgaris Model Rats Laura noviani; Muhammad Eko Irawanto; Endra Yustin Ellistasari; Arie Kusumawardani; Nurrachmat Mulianto
Journal of Social Research Vol. 5 No. 4 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i4.3102

Abstract

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit associated with Cutibacterium acnes colonization and activation of the Toll-like receptor–NF-?B pathway, which upregulates production of inflammatory mediators such as interleukin-6 (IL-6). Bromelain, a proteolytic enzyme derived from pineapple (Ananas comosus), is known to possess anti-inflammatory properties; however, experimental evidence regarding its effect on inflammatory cytokines in acne remains limited. This study aimed to evaluate the effect of oral bromelain administration on IL-6 levels in the tissue of acne vulgaris model rats. This in vivo laboratory experimental study employed a posttest-only control group design. Fifteen male Sprague-Dawley rats induced with C. acnes were divided into three groups: normal control (K1), negative control (K2), and treatment group (P) receiving oral bromelain at 88 mg/kgBW/day for 21 days. Tissue IL-6 levels were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using one-way ANOVA followed by a post hoc least significant difference (LSD) test. C. acnes induction significantly elevated tissue IL-6 levels compared to the normal control (p<0.001). One-way ANOVA revealed statistically significant differences in IL-6 levels between groups (p<0.001). The lowest IL-6 levels were observed in K1 (36.50±0.43) and the highest in K2 (94.01±0.57). The treatment group (P; 47.46±0.83) demonstrated significantly lower IL-6 levels than K2 and approximated K1 values. The post hoc LSD test confirmed statistically significant differences across all pairwise group comparisons (p<0.001). Oral bromelain administration effectively reduced IL-6 levels in the tissue of acne vulgaris model rats, demonstrating significant anti-inflammatory activity. These findings suggest that bromelain has potential as an adjunct therapy for inflammatory control in acne vulgaris.
Correlation Between Serum Il-24 Level in Acne Vulgaris Patients of Varying Clinical Severity Annisa Marsha Evanti; Muhammad Eko Irawanto; Nurrachmat Mulianto; Arie Kusumawardani; Endra Yustin Ellistasari
Journal of Social Research Vol. 5 No. 4 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i4.3104

Abstract

Background: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit that significantly impacts patients' quality of life. The inflammatory process involves immune responses partially regulated by IL-24, suggesting its potential role in AV pathophysiology and clinical severity. However, data on serum IL-24 levels based on AV severity remain limited, particularly in Indonesia. This study aims to evaluate the relationship between serum IL-24 levels and acne vulgaris severity to further elucidate its molecular mechanisms. Methods: This observational analytical study with a cross-sectional design was conducted at Dr. Moewardi General Hospital, Surakarta, Indonesia, from November 2025 to January 2026, involving healthy individuals and acne vulgaris patients. AV severity was assessed using the Lehmann classification, and serum IL-24 levels were measured by ELISA. Results: A total of 60 subjects were involved, consisting of 15 healthy controls, 15 patients with mild AV, 15 with moderate AV, and 15 with severe AV. Pearson correlation analysis showed no significant relationship between serum IL-24 levels and AV severity (p = 0.186). However, there was a trend towards increasing serum IL-24 levels along with acne severity. In the healthy control group, IL-24 levels were lower than in the AV group. Conclusions: Serum IL-24 levels are not associated with acne vulgaris severity. This is likely due to its effect on local keratinocyte proliferation. Further research is needed to elucidate the pathophysiology using histopathological examination of skin tissue from patients with AV
Co-Authors Adniana Nareswari Agung Triana Ahmad Fiqri Ambar Aliwardani Ambar Aliwardani Ambar Aliwardani Ammarilis Murastami Ance Imelda Betaubun Anggana Rafika Paramitasari Annisa Marsha Evanti Arie Kusumawardani Arie Kusumawardhani Aris Cahyono Benazier Marcella Danu Yuliarto Eka Devinta Novi Diana Ervianti Abas Ervina Rosmarwati Etty Farida Mustifah Etty Farida Mustifah Fanny Fauziyyah Heryadi Ferry Arrochman Fiska Rosita Fiska Rosita Frieda Yanuar Harijono Kariosentono Indah Julianto Indah Julianto Laura noviani Lifesia Natali Lidjaja Mardiana Mardiana Mardiana Mardiana Muhammad Eko Irawanto Muhammad Eko Irawanto Muhammad Eko Irawanto Muhammad Eko Irawanto Nugrohoaji Dharmawan Nugrohoaji Dharmawan Nurrachmat Mulianto Nurrachmat Mulianto Nurrachmat Mulianto Prasetyadi Mawardi Prasetyadi Mawardi Prasetyadi Mawardi Putti Fatiharani Putti Fatiharani Dewi Putti Fatiharani Dewi Rakhma Tri Irfanti Rakhma Tri Irfanti Reti Anggraeni Rini Hastuti Rini Hastuti Rini Hastuti Rini Hastuti Sri Esa Ilona Stella Gracia Octarica Suci Widhiati Suci Widhiati Suci Widhiati Sulistiyo Sulistiyo Susanti Rosmala Dewi Ummi Rinandari Wibisono Nugraha Willa Damayanti