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All Journal International Journal of Integrated Health Sciences Indonesian Journal of Rheumatology Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation
Rachmat Gunadi Wachjudi
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Hasan Sadikin Bandung
Decision Sciences, Operations Research & Management Health Professions Medicine & Pharmacology Neuroscience Physics

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Effect Combination of Inspiratory Muscle Training and Aerobic Exercise on Cardiopulmonary Endurance and Pulmonary Function in Systemic Lupus Erythematosus Irsan Agung Ramdhani; Irma Ruslina Defi; Dian Marta Sari; Rachmat Gunadi Wachjudi
Indonesian Journal of Physical Medicine & Rehabilitation Vol 10 No 02 (2021): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36803/ijpmr.v10i02.306

Abstract

ABSTRACTIntroduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which decreasedcardiopulmonary endurance and pulmonary function are the clinical manifestations. Inspiratory MuscleTraining (IMT) has never been studied before, but aerobic exercise is commonly studied in SLE patients.This study was conducted to know the combination ef fect of IMT and aerobic exercise in SLE patients.Materials and methods: This study use quasi experimental design with pre and post-test approach.Fourteen SLE patients that included in the Lupus Low Disease Activity State (LLDAS) were givenIMT and aerobic exercise for 8 weeks. Cardiopulmonary endurance is measured by 6-minute walk test(6MWT) and Metabolic Equivalents (METs), pulmonary function by Maximal Inspiratory Pressure(MIP), Forced Expiratory Volume in 1 second (FEV1), and Forced Vital Capacity (FVC).Results: There is significant increase in pre and post intervention data, 397.45 ± 49.34 vs 427.50 ± 48.67for 6MWT; 5.25 ± 1.14 vs 5.84 ± 1.08 for METs; 56.20 ± 14.24 vs 86.36 ± 20.73 for MIP; 68.00 ± 10.71vs 72.90 ± 11.30 for FEV1; and 1.81 ± 1 1.14 vs 77.36 ± 11.80 for FVC.Conclusion: The combination of IMT and aerobic exercise can increase cardiopulmonary endurance andpulmonary function in SLE patients.Keywords: aerobic, inspiratory muscle training, lupus low disease activity state, maximal inspiratorypressure, metabolic equivalents, six-minute walk test.
Effect Combination of Inspiratory Muscle Training and Aerobic Exercise on Cardiopulmonary Endurance and Pulmonary Function in Systemic Lupus Erythematosus Irsan Agung Ramdhani; Irma Ruslina Defi; Dian Marta Sari; Rachmat Gunadi Wachjudi
Indonesian Journal of Physical Medicine & Rehabilitation Vol 10 No 02 (2021): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36803/ijpmr.v10i02.306

Abstract

ABSTRACTIntroduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which decreasedcardiopulmonary endurance and pulmonary function are the clinical manifestations. Inspiratory MuscleTraining (IMT) has never been studied before, but aerobic exercise is commonly studied in SLE patients.This study was conducted to know the combination ef fect of IMT and aerobic exercise in SLE patients.Materials and methods: This study use quasi experimental design with pre and post-test approach.Fourteen SLE patients that included in the Lupus Low Disease Activity State (LLDAS) were givenIMT and aerobic exercise for 8 weeks. Cardiopulmonary endurance is measured by 6-minute walk test(6MWT) and Metabolic Equivalents (METs), pulmonary function by Maximal Inspiratory Pressure(MIP), Forced Expiratory Volume in 1 second (FEV1), and Forced Vital Capacity (FVC).Results: There is significant increase in pre and post intervention data, 397.45 ± 49.34 vs 427.50 ± 48.67for 6MWT; 5.25 ± 1.14 vs 5.84 ± 1.08 for METs; 56.20 ± 14.24 vs 86.36 ± 20.73 for MIP; 68.00 ± 10.71vs 72.90 ± 11.30 for FEV1; and 1.81 ± 1 1.14 vs 77.36 ± 11.80 for FVC.Conclusion: The combination of IMT and aerobic exercise can increase cardiopulmonary endurance andpulmonary function in SLE patients.Keywords: aerobic, inspiratory muscle training, lupus low disease activity state, maximal inspiratorypressure, metabolic equivalents, six-minute walk test.
B-Cell Activating Factor Profile and Quality of Life in Systemic Lupus Erythematosus Patients Andri Reza Rahmadi; Habib Burahman; Nadia Gita Ghassani; Rachmat Gunadi Wachjudi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i2.204

Abstract

Background: B-Cell Activating Factor (BAFF) is a cytokine that plays a role in systemic lupus erythematosus (SLE) pathogenesis. BAFF increases B cell function, which will affect disease activity. In addition to decreasing disease activity, good quality of life (QoL) is one of the goals to be achieved in SLE therapy, which is also affected by disease activity. The purpose of this study is to know the correlation of the BAFF profile with the QoL of SLE patients. Methods: This was a cross-sectional study using secondary data from a previous study. The subjects of this study were SLE patients who had visited the rheumatology outpatient clinic or were hospitalized in Hasan Sadikin Hospital Bandung from September 2016 until February 2017. Subjects were asked to complete the Short Form-36 and measure their BAFF level in serum. Demographic data were collected, and disease activity data were assessed by Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). The statistical analysis used in this study was the Spearman test. Results: There was a positive correlation between BAFF and MEX-SLEDAI (r 0.238, p-value 0.038). There was also a negative correlation between MEX-SLEDAI and PCS, as well as the MCS score (r -0.392 and -0.371, p-value <0.05). Conclusion: BAFF levels will increase in higher disease activity which will affect a poorer quality of life.
Autoantibody Profile and Lung HRCT Scan in Systemic Sclerosis with Restrictive Lung Disease Saragih, Winda Agnestia Maranna; Dewi, Sumartini; Wachjudi, Rachmat Gunadi; Logito, Verina; Tjandrawati, Anna
International Journal of Integrated Health Sciences Vol 11, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v11n1.3020

Abstract

Objective: To identify auto-antibodies in systemic sclerosis with interstitial lung disease (ILD). Method: This was a descriptive categorical study on auto-antibody profile in systemic sclerosis patients visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital, West Java, and Bandung during the period of January 2018 to December 2019 who were registered in the West Java Systemic Sclerosis Registry. Auto-antibody identification was performed using the Euroline immunoblot assays.Results: Thirty six cases were identified during the study period with most of the cases involved women (n=35, 97.2%). The average age of patients participating in this study was 40 years, with an average duration of disease of 18 months. Diffuse cutaneous systemic sclerosis was found in 22 (61.1%) cases and limited cutaneous systemic sclerosis was observed in 14 (38.9%) cases. Specific autoantibodies were positive in 33 (91.6%) cases, with anti-topoisomerase I as the largest group, positive in 22 (52.9.3%) cases. This was followed by anti-Th/To in eight (15.7%) cases; anti-Ro52 in four (7.8%) cases; anti-centromere in three (5.9%) cases; anti-RNA polymerase in three (5.9%) cases; anti-fibrillarin in three (5.9%) cases; anti-Ku in two (3.9%) cases; and anti-PDGF in one (2.0%) case. High-resolution computed tomography of the lung showed 34 (94.4%) cases with ILD and 22 (61.1%) cases with severe lung fibrosis. Usual interstitial pneumonia was seen in 19 (52.8%) cases and non-specific interstitial pneumonia in 15 (41.7%) cases.Conclusion: Anti-topoisomerase I, anti-Th/To, and anti-Ro52 are the most common autoantibodies observed in systemic sclerosis patients with ILD as the most prevalent feature detected with lung HRCT.
Co-Authors A Nawawi A Oehadian Adnyana, I K Alfarish, M Arzan Andri Reza Rahmadi Anna Tjandrawati Arie Taufik Bambang Setyohadi Bambang Setyohadi Deddy Nur Wachid Achadiono Dewi, Sumartini Dian Marta Sari Guntur Darmawan H Tansah Habib Burahman Handono Kalim Handono Kalim Harry Isbagio Harry Isbagio I Ketut Adnyana Irma Ruslina Defi Irsan Agung Ramdhani Joewono Soeroso Joewono Soeroso Laniyati Hamijoyo Laniyati Hamijoyo, Laniyati Limanjaya, W R Logito, Verina M Arzan Alfarish Maslim, Y Nadia Gita Ghassani Nawawi, A Oehadian, A Putri Vidyaniati Salim, Susanto Saragih, Winda Agnestia Maranna Stefanie Yuliana Usman Sumartini Dewi Sumartini Dewi Sumartini Dewi Sumartini Dewi Sumartini Dewi Susanto Salim Tansah, H Vincent Vincent Vincent Vincent, Vincent W R Limanjaya Wisynu Tresnadi A.B Y Maslim