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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis
Lale Maulin Prihatina
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Materials Science & Nanotechnology Physics

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Relationship Between S100 Protein Expression and Grading Meningioma Lale Maulin Prihatina; Rohadi; Bambang Priyanto; Decky Aditya Zulkarnaen; Abdul Syukur
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11529

Abstract

Meningioma is the most common type of benign brain tumor in adults and mostly originates from the meningeal layer of the brain and spinal cord. The prevalence of meningioma in the world is estimated to be about 24-30% of intracranial primary brain tumors. This tumor is classified into three groups based on grade, grade I (benign), grade II (atypical), and grade III (anaplastic). The S100 protein is not specific to meningiomas but some studies have shown that the expression of S100 protein is stronger in grade I meningiomas than in grade II and III meningiomas. Based on these findings, the authors are interested in analyzing whether there is a relationship between S100 expression and meningioma grading. The determination of S100 protein expression is very necessary as a reference in determining the prognosis and selection of the best therapy for patients. This research was carried out in the period from January 2021 to December 2021. 9 samples were included in this study according to the inclusion and exclusion criteria. The data was analyzed using SPSS version 26. The results of this study: A normality test was carried out with the Shapiro Wilk test and a value of p=0.34 (CI 95%) was obtained using Spearman analysis.
Association Between Molecular Subtypes and Histopathological Features in Breast Cancer at NTB Provincial Hospital Salman Fawwaz Wahid; Hadian Rahman; Lale Maulin Prihatina
Jurnal Biologi Tropis Vol. 26 No. 4 (2026): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i4.13370

Abstract

Breast cancer ranks second in global cancer incidence among women and is the leading cancer type and cause of cancer-related mortality among women in Indonesia. Four molecular subtypes Luminal A, Luminal B, HER2-enriched, and triple-negative breast cancer (TNBC) are identified through immunohistochemistry (IHC) and differ in clinical behavior and prognosis, but their relationship with histopathological features remains unexamined in this region. This study evaluated associations between IHC-defined molecular subtypes and histopathological type and grade among breast cancer patients at NTB Provincial Hospital. This cross-sectional study used medical records from 361 consecutive patients who underwent IHC testing in 2023-2024. Subtypes were compared using Pearson’s chi-square test, with Cramér’s V measuring effect size; luminal and non-luminal groups were also analyzed separately. Luminal B was most common (47.1%), followed by HER2-enriched (18.8%), TNBC (18.0%), and Luminal A (16.1%). Ductal carcinoma accounted for 85.6% of cases, and 72.3% were Grade 3. Histological grade differed significantly across subtypes (p=0.019; V=0.17), with the lowest proportion of high-grade tumors in Luminal A and the highest in TNBC. Histological type did not differ significantly (p=0.063; V=0.14). Luminal versus non-luminal status was associated with histological type (p=0.026), but not grade (p=0.154).
Oligodendroglioma: Morphology, Pathogenesis, and Prognosis Factors Ibtisamy Amaliya; Rohadi Rohadi; Lale Maulin Prihatina
Jurnal Biologi Tropis Vol. 26 No. 4 (2026): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i4.13558

Abstract

Oligodendroglioma is a type of glial tumor that originates from oligodendrocyte cells. This tumor is relatively rare accounting for approximately 5–20% of all glial tumors. This article aims to study more deeply about the morphology, pathogenesis, and prognosis factors of oligodendroglioma. The method used is literature review by searching and collecting information from several scientific databases, such as PubMed, Google Scholar, and National Center for Biotechnology Information (NCBI). The result of this article shows that, according to the 2021 World Health Organization (WHO) classification, oligodendroglioma is classified as an adult-type diffuse glioma, a group of tumors that predominantly occur in adults. Based on histological characteristics, oligodendroglioma is categorized into low-grade (WHO grade 2) and high-grade (WHO grade 3) tumors. Tumor cells typically exhibit round nuclei with well-defined cell membranes and clear cytoplasm surrounding the centrally located nuclei, producing the characteristic "fried-egg appearance." A definitive diagnosis of oligodendroglioma requires evidence of an IDH1 or IDH2 mutation and combined loss of the short arm of chromosome 1 and the long arm of chromosome 19 (1p/19q codeletion). Genetic alterations, age, tumor size, and immune status may contribute to determining patient prognosis. In conclusion, oligodendroglioma is a rare tumor characterized by distinctive morphological features that influence patient prognosis.
Co-Authors Abdul Syukur Bambang Priyanto Decky Aditya Zulkarnaen Hadian Rahman Ibtisamy Amaliya Rohadi Salman Fawwaz Wahid