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All Journal Indonesian Journal of Global Health research Jurnal Indonesia Sosial Sains Jurnal Adijaya Multidisiplin International Journal Of Health And Social Behavior
Mara Imam Taufiq Siregar
Universitas Jambi
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Correlation Clinicopathological and Immunohistochemical Expression of Interleukin-6 (IL-6) in Keloid Fairuz Fairuz; Erisca Utami; Hasna Dewi; Fitriyanti Fitriyanti; Miftahurrahma Miftahurrahma; Budi Justitia; Mara Imam Taufiq Siregar; Humaryanto Humaryanto
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.5844

Abstract

IL-6 has been shown to enhance collagen synthesis and prolong the fibroblast proliferative phase, potentially contributing to uncontrolled keloid growth. However, despite its frequent mention in the literature as a crucial factor in keloid formation, studies specifically exploring the molecular mechanisms of IL-6 in fibroblast regulation and its interaction with other cytokines within keloid tissue remain limited. This study aims to further investigate the role of IL-6 in keloid matrix formation. This study is an analytical study conducted cross-sectionally. The samples used were patients diagnosed with keloids histopathologically based on microscopic criteria. Clinical data were taken from medical records and microscopic and immunohistochemical assessments using paraffin blocks available in the anatomical pathology laboratory of hospitals in Jambi city. There were 36 cases of keloids, aged between 12 and 42 years, mostly in women (66.7%), occurring in the trunk area (77.8%) 30 cases of recurrence (83.3%). We found 24 cases (77.8%) with strong IL-6 immunoexpression. There were 3 cases (8.3%) with no immunoexpression. There was a strong correlation between IL-6 immunoexpression and gender (p=0.03), age(0.04) and recurrence (p=0.02). The role of fibroblast cells is very important for the process of collagen formation in wound healing. The role of fibroblast cells is very important for the process of collagen formation in wound healing, where interleukin-6 in various theories and studies supports the process of collagen formation.
Gambaran Karakteristik Pasien Yang Dirawat di Unit Perawatan Intensif RSUD Raden Mattaher Jambi Periode 2024 –2025 Attiya Dyah Ajeng Cahyaningsasi; Ade Susanti; Humaryanto; Mara Imam Taufiq Siregar; Hanina
Jurnal Adijaya Multidisplin Vol 4 No 04 (2026): Jurnal Adijaya Multidisiplin (JAM)
Publisher : PT Naureen Digital Education

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Unit Perawatan Intensif (UPI) memberikan pelayanan kepada pasien dengan kondisi kritis yang membutuhkan pemantauan ketat, terapi intensif, dan dukungan organ. Gambaran karakteristik pasien diperlukan untuk memahami pola pelayanan serta menjadi dasar evaluasi dan perencanaan sumber daya rumah sakit. Penelitian ini bertujuan untuk menggambarkan karakteristik pasien yang dirawat di UPI RSUD Raden Mattaher Jambi periode 2024–2025 menggunakan pendekatan deskriptif dengan penelusuran retrospektif terhadap dokumen rekam medis pasien. Data yang dikaji meliputi usia, jenis kelamin, lama rawat, dan indikasi masuk UPI. Sebanyak 1.048 rekam medis pasien yang memenuhi kriteria penelitian dianalisis secara deskriptif dalam bentuk frekuensi dan persentase. Hasil penelitian menunjukkan bahwa sebagian besar pasien berusia 19–59 tahun, yaitu 731 pasien (69,8%), diikuti usia ≥60 tahun sebanyak 313 pasien (29,9%) dan usia ≤18 tahun sebanyak 4 pasien (0,4%). Distribusi jenis kelamin relatif seimbang, terdiri atas 528 pasien perempuan (50,4%) dan 520 pasien laki-laki (49,6%). Sebagian besar pasien menjalani perawatan selama ≤7 hari, yaitu 961 pasien (91,7%), sedangkan 87 pasien (8,3%) dirawat >7 hari. Berdasarkan indikasi masuk, pasien bedah merupakan kelompok terbanyak sebanyak 781 pasien (74,5%), sedangkan pasien dengan indikasi medis berjumlah 267 pasien (25,5%). Secara umum, pasien UPI didominasi oleh usia dewasa, lama rawat ≤7 hari, dan indikasi bedah. Hasil penelitian ini dapat digunakan sebagai informasi dasar dalam evaluasi pelayanan, perencanaan kebutuhan sumber daya, serta pengembangan penelitian lanjutan mengenai karakteristik pasien kritis di rumah sakit.
The Relationship between Knowledge about Anesthesia Procedures and the Anxiety of Patients Who Will Undergo Surgery at RSUD Raden Mattaher Jambi Tianingsih Tianingsih; Mara Imam Taufiq Siregar; Huntari Harahap; Andy Hutariyus; Budi Justitia
International Journal of Health and Social Behavior Vol. 3 No. 3 (2026): August: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v3i3.656

Abstract

Background: Preoperative anxiety is a common response to perceived physical and psychological threats that may affect hemodynamic stability, increase postoperative pain, prolong hospitalization, and even lead to surgery cancellation. Limited knowledge of anesthesia procedures is considered an important contributing factor because inadequate information can increase fear and unpreparedness before surgery. Methods: This cross-sectional study involved 126 patients undergoing elective surgery at Raden Mattaher Regional General Hospital, Jambi. Respondents were selected based on the criteria of age ≥18 years, ASA physical status I–II, literacy, and willingness to participate. Data on anesthesia-related knowledge and preoperative anxiety were collected using structured questionnaires. The relationship between variables was analyzed using the Kolmogorov–Smirnov test because the assumptions for the Chi-square test were not fulfilled. Results: Most respondents were aged 51–60 years, had completed senior high school, were employed, had no previous surgical experience, presented with hypertension, and had normal pulse rates. Moderate knowledge (48.4%) and moderate anxiety (48.2%) were the most common findings. Statistical analysis demonstrated a significant association between knowledge of anesthesia procedures and preoperative anxiety (p = 0.0001). Conclusion: Improving patients' knowledge through comprehensive preoperative education may reduce anxiety, enhance readiness, and support physiological stability before elective surgery.  
The Relationship between Comorbidities and Mortality among Covid-19 Patients at Raden Mattaher General Hospital in Jambi Fesi Putri Alwi; Makrup Efendy; Mara Imam Taufiq Siregar; Dicky Wahyudi; Wahyu Indah Dewi Aurora; Fitriyanti Fitriyanti
Jurnal Indonesia Sosial Sains Vol. 7 No. 7 (2026): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v7i7.2412

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Patients with comorbidities have a higher risk of mortality compared to patients without comorbidities. Objective: This study aims to analyze the relationship between comorbidities and mortality in COVID-19 patients at Raden Mattaher General Hospital in Jambi. Methods: This study is an observational analytical study with a retrospective approach using a cross-sectional design. The minimum sample size was 133 patients with comorbidities and 133 patients without comorbidities. The study utilized secondary data in the form of medical records, and the analysis employed the Chi-Square test. Results: The study sample consisted of 294 patients. Regarding sample characteristics, the largest age group was 56–64 years (27.6%), and the sample was predominantly male (54.4%). The most common comorbidities were diabetes mellitus (21.1%), hypertension (10.2%), chronic kidney disease (9.2%), hypertensive heart disease (5.4%), acute kidney injury (2.4%), and tuberculosis (1.7%). The proportion of patients with a deceased status was (15.3%) Bivariate analysis results indicated an association between comorbidities and mortality among COVID-19 patients at Raden Mattaher General Hospital in Jambi, with a p-value of 0.006 (p < 0.05). Conclusion: There is an association between comorbidities and mortality in COVID-19 patients at Raden Mattaher General Hospital in Jambi.
Co-Authors Ade Susanti Andy Hutariyus Attiya Dyah Ajeng Cahyaningsasi Budi Justitia dewi, hasna Dicky Wahyudi Erisca Utami Fairuz Quzwain Fesi Putri Alwi Fitriyanti Fitriyanti Hanina Harahap, Huntari Humaryanto Humaryanto Humaryanto Makrup Efendy Miftahurrahma Miftahurrahma Tianingsih Tianingsih Wahyu Indah Dewi Aurora