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Purnaningtyas, Sri Rahayu Dwi
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Journal : Strada Journal of Pharmacy

 1 
Analysis of free Fatty Acid Levels (as Lauric Acid) Pure Coconut Oil (Virgin Coconut Oil / VCO) for sale in Kediri City Sri Rahayu Dwi Purnaningtyas
Strada Journal of Pharmacy Vol. 4 No. 1 (2022): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i1.48

Abstract

Pure Coconut Oil (Virgin Coconut Oil / VCO) is a vegetable oil that contains medium chain saturated fatty acids. The medium-chain saturated fatty acid that has the highest content in virgin coconut oil is lauric acid. Lauric acid can be directly absorbed by the liver and used as an energy source. This study aims to determine the levels of free fatty acids (as lauric acid) in virgin coconut oil (Virgin Coconut Oil/VCO) according to SNI Standard 7381: 2008. The samples used in this study were pure coconut oil from various brands on the market in Indonesia. Kediri city. This study used an alkalimetry method to identify the free fatty acid levels in the sample. From the results of the analysis on 5 (five) brands of virgin coconut oil, it was found that all samples met the requirements of SNI 7381: 2008 which is a maximum of 0.2%. The results of the analysis of the levels of free fatty acids as lauric acid, the smallest 0.1643% and the largest 0.1988% according to the requirements of SNI.
Analysis of Free Fatty Acid Contents (As Acid Laurat) Pure Coconut Oil (Virgin Coconut Oil /VCO) which Circulates in Kediri City Sri Rahayu Dwi Purnaningtyas
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.167

Abstract

Pure Coconut Oil (Virgin Coconut Oil / VCO) is a vegetable oil that contains medium chain saturated fatty acids. The medium-chain saturated fatty acid that has the highest content in virgin coconut oil is lauric acid. Lauric acid can be directly absorbed by the liver and used as an energy source. This study aims to determine the levels of free fatty acids (as lauric acid) in virgin coconut oil (Virgin Coconut Oil/VCO) according to SNI Standard 7381: 2008. The samples used in this study were pure coconut oil from various brands on the market in Indonesia. Kediri city. This study used an alkalimetry method to identify the free fatty acid levels in the sample. From the results of the analysis on 5 (five) brands of virgin coconut oil, it was found that all samples met the requirements of SNI 7381: 2008 which is a maximum of 0.2%. The results of the analysis of the levels of free fatty acids as lauric acid, the largest 0.1988% and the smallest 0.1643% according to the requirements of SNI.
The Potential of Quercetin as Parkinson's Disease Therapy Assessed From Binding Affinity To Adenosine A2a Receptor Using In-Silico Adjie Wahyu Pradana; Sri Rahayu Dwi Purnaningtyas; Devita Riafinola Andaririt; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.156

Abstract

Parkinson's disease is a degenerative disease that causes impaired mobility and muscle control caused by decreased dopamine production in the brain. Parkinson's disease therapy is dopaminergic therapy using levodopa which works by replacing the reduced dopamine, the use of levodopa has side effects such as dizziness, nausea, and excessive sleepiness. The use of istradefylline with levodopa as a non-dopaminergic therapy in parkinson's reduces side effects and increases therapeutic targets. Quercetin is thought to have activity in improving motor function in parkinson's. The aim of this study was to look at the potential of quercetin as a parkinson's therapy. Objective: Finding the activity of quercetin as Parkinson's therapy compared with istradefylline using in-silico. Method: The design of this study is in-silico, which is a study using the help of computer calculations, the method used is molecular docking based on the principle of bonding compounds to receptors. Ligand compounds obtained from PubChem and receptor clusters obtained from Protein Data Bank. The docking Software used is Pyrex, and Discovery Studio Analizer. Independent variables in this study were quercetin and istradefylline, while the dependent variable was binding affinity ligand to adenosine A2a receptor. In this study, statistical analysis was conducted using an independent sample t-test. Results: In-silico test with molecular docking method showed each 9 ligand position to the receptor, the results of data analysis with the test of independent sample t-test, at the degree of significance α = 0.05 obtained statistical results with a significance value of 0.013 which means that the quercetin ligand has stronger potential compared to istradefylline. Quercetin has a binding affinity value of -8.1 kcal/mol, while istradefylline has a binding affinity value of -6.9 kcal / mol. Conclusion: Quercetin has been shown to have potential as an alternative therapy for parkinson's disease
Co-Authors Adjie Wahyu Pradana Arif Wijayanto Basri Noor Cahyadi Devita Riafinola Eka Cahya Muliawati La Febry Andira Rose Cynthia Mila Sari Mohammad Chasrun Hasani Putri, Luluk Aniqoh Meliana Syafaah, Lailis