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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Kesehatan Farmasi Nusantara Journal of Pharmaceutical and Natural Resources
Atri Sri Ulandari
Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health

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Perbandingan Aktivitas Antibakteri pada Berbagai Konsentrasi Ekstrak Bunga Telang (Clitoria ternatea L.) terhadap Staphylococcus aureus: Suatu Tinjauan Naratif Anisa Safitri; Atri Sri Ulandari; Afriyani Afriyani; Zulpakor Oktoba
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 1 (2026): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i1.958

Abstract

Introduction: Staphylococcus aureus infection remains a major health problem due to the increasing resistance to conventional antibiotics. Butterfly pea flower (Clitoria ternatea L.) contains bioactive compounds with potential antibacterial properties. This study aimed to evaluate the antibacterial effectiveness of butterfly pea flower extract and to assess the effect of extract concentration variation against Staphylococcus aureus. Method: This study employed a narrative literature review by searching articles from Google Scholar (1,130 articles), PubMed (2 articles), and ScienceDirect (235 articles) published between 2015 and 2025. Articles were selected based on inclusion criteria, namely experimental studies using Staphylococcus aureus as the test bacterium and reporting variations in butterfly pea flower extract concentrations. Exclusion criteria included review articles or proceedings, studies without inhibition zone data, studies not using Staphylococcus aureus, and articles not available in full text. Articles meeting the criteria were analyzed descriptively and comparatively (n = 9 articles). Discussion: Analysis of the nine selected studies indicated that increasing concentrations of butterfly pea flower extract were associated with larger inhibition zones against Staphylococcus aureus. Variations in results were influenced by solvent type, extraction methods, and antibacterial testing techniques. Conclusion: Butterfly pea flower extract demonstrated consistent antibacterial activity against Staphylococcus aureus, particularly at higher concentrations, suggesting its potential development as a natural antibacterial active ingredient.
Systematic Review: Mechanism of Ginger (Zingiber offinale) as Anti-inflammatory Dwi Monika Ningrum; Denih Agus Setia Permana; Atri Sri Ulandari
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp20-23

Abstract

The appearance of inflammation is a hallmark of a large number of human diseases, ranging from infection to neurodegeneration. In the treatment of inflammation, a group of drugs that are widely given are non-steroidal anti-inflammatory drugs (NSAIDs). Long-term use of NSAIDs can result in various side effects, namely gastrointestinal disorders, damage to the kidneys, and cardiovascular disorders. Given the side effects that can be caused by the use of NSAIDs, other alternatives are needed to overcome and reduce inflammation. One of the plants that can be used to treat inflammation is ginger. This journal review was conducted by reviewing electronic journals related to the use of ginger as an anti-inflammatory mechanism with the study report method. The inclusion criteria used include ginger as an anti-inflammatory, journals from 2008-2012, journals are scientific journals, in vitro and in vivo, free full text, while the exclusion criteria are the benefits of ginger not as an anti-inflammatory. Ginger as an anti-inflammatory has several mechanisms including inhibiting macrophage activation, increasing endogenous antioxidant activity, inhibiting the production of PGE2, tumor necrosis factor α (TNFα), and cyclooxygenase. Inhibition of cyclooxygenase is selective only for COX-2 activity. COX-1 inhibition is associated with gastrointestinal irritation, selective inhibition of COX-2 will help minimize side effects.
Studi Literatur : Pengaruh Konsentrasi Dan Kombinasi Basis Terhadap Karakteristik Masker Gel Peel-Off Dari Bahan Alam Ariza Anggun Maharani; Afriyani Afriyani; Atri Sri Ulandari
Jurnal Kesehatan Farmasi Nusantara Vol. 2 No. 2 (2026): MEI
Publisher : PT Mara Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64465/jkfn.v2i2.92

Abstract

Masker gel peel-off adalah sediaan kosmetik topikal yang banyak dikembangkan karena praktis, nyaman, dan efektif membersihkan kulit. Karakteristik fisiknya dipengaruhi oleh jenis serta konsentrasi basis, terutama pembentuk film dan pembentuk gel. Penelitian ini bertujuan mengkaji pengaruh kombinasi dan konsentrasi basis pada masker gel peel-off berbahan alam melalui studi literatur. Metode yang digunakan adalah literature review terhadap artikel nasional dan internasional dari Google Scholar periode 2021–2026 yang diseleksi berdasarkan kriteria inklusi dan eksklusi. Hasil menunjukkan bahwa Polyvinyl Alcohol (PVA) umum digunakan sebagai pembentuk film (3–14%) dan dikombinasikan dengan gelling agent seperti Carbopol 940, gelatin, HPMC, Na.CMC, dan HEC. Variasi jenis dan konsentrasi berpengaruh terhadap pH, daya sebar, dan waktu kering sediaan. Kombinasi pada konsentrasi yang tepat menghasilkan sediaan dengan karakteristik fisik yang baik, stabil, dan memenuhi standar mutu kosmetik.
Analisis Aktivitas Antioksidan Ekstrak Daun Katang-Katang (Ipomea pes caprae) dengan Metode DPPH : Literature Review Tsania Zahra Taslima; Zulpakor Oktoba; Atri Sri Ulandari; Muhammad Iqbal
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 1 (2025): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i1.594

Abstract

Free radicals are reactive molecules that contribute to oxidative stress, triggering cellular damage and leading to degenerative diseases such as cancer, diabetes, and cardiovascular diseases. Antioxidants are required to neutralize free radicals and protect the body from oxidative damage. The leaves of Ipomoea pes-caprae (L.) R. Br. contain secondary metabolites, such as flavonoids and phenolics, which have potential antioxidant activity. This article aims to analyze the antioxidant activity of Ipomoea pes-caprae leaf extract using the DPPH method. The study employed a literature review approach using Google Scholar with specific keywords and 13 articles met the inclusion criteria with a  publication range from 2015 to 2025. The findings indicate that the extraction method and type of solvent significantly affect the effectiveness of antioxidant activity. Maceration and Soxhlet extraction methods were effective in isolating active compounds, particularly flavonoids and phenolics, while polar solvents such as ethanol and methanol produced better results compared to non-polar solvents. Antioxidant strength, determined by IC50 values, ranged from very strong to very weak. Therefore, it can be concluded that selecting the appropriate extraction method and solvent is crucial to maximizing the antioxidant potential of Ipomoea pes-caprae leaves as a natural antioxidant source for health and pharmaceutical applications.  
Kandungan Senyawa Fitokimia dan Aktivitas Antibakteri Ekstrak Daun Pepaya (Carica Papaya L.): Narrative Review Umniyah Tsabitah Zahrani; Ihsanti Dwi Rahayu; Atri Sri Ulandari; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.599

Abstract

This narrative review article explores the potential of papaya leaves (Carica papaya L.) as an alternative antibacterial treatment due to the increasing problem of antibiotic resistance. Papaya leaves, commonly found in Indonesia, are known to have various pharmacological properties, including antibacterial effects. The article aims to collect and review existing literature on the phytochemical compounds and antibacterial activity of papaya leaf extract. Literature searches were conducted across several databases such as Google Scholar, NCBI, ResearchGate, and ScienceDirect using keywords like "antibacterial," "phytochemical screening," and "Carica papaya leaf." Articles from the last five years that were accessible in full text and relevant to the topic were selected, leading to the inclusion of 18 articles in the review.The findings indicate that papaya leaf extracts exhibit antibacterial properties against both gram-positive and gram-negative bacteria. The degree of antibacterial activity varies, ranging from weak to very strong inhibition. This antibacterial effect is attributed to the secondary metabolite compounds present in papaya leaves, including alkaloids, flavonoids, saponins, tannins, phenolics, terpenoids, and steroids. These compounds contribute to the biological activity of the extract, making it a promising candidate for further development as a natural antibacterial agent. Overall, this review underscores the importance of exploring medicinal plants like papaya leaves as viable alternatives to combat bacterial infections and address the growing issue of antibiotic resistance..
Pengembangan Nanoemulsi dari Bahan Alam Famili Anacardiaceae sebagai Sistem Penghantaran Senyawa Aktif Antibakteri: Narrative Review Loisa Nopratity Reza; Afriyani Afriyani; Atri Sri Ulandari; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 2 (2026): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i2.975

Abstract

Antibiotic resistance has become a major global health concern, prompting the exploration of natural antibacterial agents and advanced drug delivery systems. Plants from the Anacardiaceae family are known to contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and fatty acids, which exhibit antibacterial properties. However, the effectiveness of these compounds is often limited by poor solubility and stability. This study aimed to analyze the development of nanoemulsion formulations derived from Anacardiaceae plants as antibacterial delivery systems through a narrative review approach. Literature was collected from NCBI and Google Scholar databases using relevant keywords, resulting in six eligible research articles published between 2016 and 2025. The findings indicate that nanoemulsions produced using both high-energy and low-energy methods exhibit droplet sizes within the nanometer range, with low-energy methods generally producing smaller and more homogeneous droplets. Nevertheless, antibacterial activity varied from weak to strong depending on plant species and bioactive composition, and was not directly correlated with droplet size alone. Overall, nanoemulsions enhance the stability and delivery of bioactive compounds, but their antibacterial effectiveness is strongly influenced by formulation optimization and the type of active compounds. These findings highlight the importance of systematic formulation strategies in developing effective natural antibacterial nanoemulsions Keywords: Anacardiaceae, Antibacterial activity, Nanoemulsion
Co-Authors Afriyani Afriyani Anisa Safitri Ariza Anggun Maharani Dwi Monika Ningrum Ihsanti Dwi Rahayu Loisa Nopratity Reza Muhammad Iqbal Oktoba, Zulpakor Ramadhan Triyandi Tsania Zahra Taslima Umniyah Tsabitah Zahrani