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p-Index From 2021 - 2026
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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Journal of Pharmaceutical and Natural Resources
Atri Sri Ulandari
Universitas Lampung
Health Professions Medicine & Pharmacology Public Health

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Perbandingan Aktivitas Antibakteri pada Berbagai Konsentrasi Ekstrak Bunga Telang (Clitoria ternatea L.) terhadap Staphylococcus aureus: Suatu Tinjauan Naratif Anisa Safitri; Atri Sri Ulandari; Afriyani Afriyani; Zulpakor Oktoba
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 1 (2026): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i1.958

Abstract

Introduction: Staphylococcus aureus infection remains a major health problem due to the increasing resistance to conventional antibiotics. Butterfly pea flower (Clitoria ternatea L.) contains bioactive compounds with potential antibacterial properties. This study aimed to evaluate the antibacterial effectiveness of butterfly pea flower extract and to assess the effect of extract concentration variation against Staphylococcus aureus. Method: This study employed a narrative literature review by searching articles from Google Scholar (1,130 articles), PubMed (2 articles), and ScienceDirect (235 articles) published between 2015 and 2025. Articles were selected based on inclusion criteria, namely experimental studies using Staphylococcus aureus as the test bacterium and reporting variations in butterfly pea flower extract concentrations. Exclusion criteria included review articles or proceedings, studies without inhibition zone data, studies not using Staphylococcus aureus, and articles not available in full text. Articles meeting the criteria were analyzed descriptively and comparatively (n = 9 articles). Discussion: Analysis of the nine selected studies indicated that increasing concentrations of butterfly pea flower extract were associated with larger inhibition zones against Staphylococcus aureus. Variations in results were influenced by solvent type, extraction methods, and antibacterial testing techniques. Conclusion: Butterfly pea flower extract demonstrated consistent antibacterial activity against Staphylococcus aureus, particularly at higher concentrations, suggesting its potential development as a natural antibacterial active ingredient.
Systematic Review: Mechanism of Ginger (Zingiber offinale) as Anti-inflammatory Dwi Monika Ningrum; Denih Agus Setia Permana; Atri Sri Ulandari
Journal of Pharmaceutical and Natural Resources Vol. 1 No. 1 (2025): Journal of Pharmaceutical and Natural Resources
Publisher : Jurusan Farmasi Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpnar.v1i1.pp20-23

Abstract

The appearance of inflammation is a hallmark of a large number of human diseases, ranging from infection to neurodegeneration. In the treatment of inflammation, a group of drugs that are widely given are non-steroidal anti-inflammatory drugs (NSAIDs). Long-term use of NSAIDs can result in various side effects, namely gastrointestinal disorders, damage to the kidneys, and cardiovascular disorders. Given the side effects that can be caused by the use of NSAIDs, other alternatives are needed to overcome and reduce inflammation. One of the plants that can be used to treat inflammation is ginger. This journal review was conducted by reviewing electronic journals related to the use of ginger as an anti-inflammatory mechanism with the study report method. The inclusion criteria used include ginger as an anti-inflammatory, journals from 2008-2012, journals are scientific journals, in vitro and in vivo, free full text, while the exclusion criteria are the benefits of ginger not as an anti-inflammatory. Ginger as an anti-inflammatory has several mechanisms including inhibiting macrophage activation, increasing endogenous antioxidant activity, inhibiting the production of PGE2, tumor necrosis factor α (TNFα), and cyclooxygenase. Inhibition of cyclooxygenase is selective only for COX-2 activity. COX-1 inhibition is associated with gastrointestinal irritation, selective inhibition of COX-2 will help minimize side effects.
Co-Authors Afriyani Afriyani Anisa Safitri Dwi Monika Ningrum Oktoba, Zulpakor