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Phytochemical Features of Moringa oleifera Leaves as Anticancer Edwinanto, Ludovicus; Septiadi, Endry; Nurfazriah, Latifah R.; Anastasya, Karina S.; Pranata, Natallia
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Cancer is a disease that can threaten human life. Various methods of cancer therapy havebeen widely practiced, one of which is chemotherapy. But the cost used for the therapy is alsovery expensive. This difficulty led many researchers to conduct research to find activecompounds from natural materials. Moringa leaf (Moringa oleifera) has cytotoxic activity,because it contains a lot of flavonoids. Flavonoids are polyphenol compounds produced fromsecondary metabolism in plants. The most flavonoids that are anticancer active substances inthe Moringa leaf are quercetin, kaempferol and myricetin. Cytotoxic activity because theseactive substances can induce apoptosis through intrinsic pathways by inhibition of mitogen-activated protein kinase (MAPK), extracellular-signal-regulated kinase 1/2 (ERK 1/2), c-Jun N-terminal protein kinase 1 (JNK), and protein kinase C (PKC).Keywords: Moringa leaf, quersetin; kaempferol; myricetin; anticancer

Dental Calculus as The Unique Calcified Oral Ecosystem A Review Article Pranata, Natallia
Oceana Biomedicina Journal Vol 2, No 2 (2019): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

The prevalence of periodontal disease in Indonesians is very high, which is around 95%, and 70% of these values occur above 30 years or the adult age group. There is controversy about whether dental calculus is an etiological factor in periodontal disease, or is it just a predisposing factor. Dental Calculus is a calcified oral ecosystem or dental plaque, can accumulate on supragingival or subgingival. Plaque is a bacterial biofilm complex on the tooth surface, including pathogenic microorganisms that invade periodontal tissue. Periodontal disease is the result of interactions between pathogens and the host immune system. Damage to periodontal tissue can occur if the pathogenicity of the microflora is more dominant in the immune response. In calcified conditions, these microorganisms lose their pathogenicity. The dental calculus is one form of the body's defense mechanism against pathogens. But the accumulation of dental calculus, with its rough surface, is a predisposing factor for plaque accumulation. The oral ecosystem trapping on the unique calcified material which are called dental calculus.

Dental Calculus as The Unique Calcified Oral Ecosystem A Review Article Natallia Pranata
Denta Journal Kedokteran Gigi Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

The prevalence of periodontal disease in Indonesians is very high, which is around 95%, and 70% of these values occur above 30 years or the adult age group. There is controversy about whether dental calculus is an etiological factor in periodontal disease, or is it just a predisposing factor. Dental Calculus is a calcified oral ecosystem or dental plaque, can accumulate on supragingival or subgingival. Plaque is a bacterial biofilm complex on the tooth surface, including pathogenic microorganisms that invade periodontal tissue. Periodontal disease is the result of interactions between pathogens and the host immune system. Damage to periodontal tissue can occur if the pathogenicity of the microflora is more dominant in the immune response. In calcified conditions, these microorganisms lose their pathogenicity. The dental calculus is one form of the body's defense mechanism against pathogens. But the accumulation of dental calculus, with its rough surface, is a predisposing factor for plaque accumulation. The oral ecosystem trapping on the unique calcified material which are called dental calculus.

Dental Calculus as The Unique Calcified Oral Ecosystem A Review Article Natallia Pranata
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.28

The prevalence of periodontal disease in Indonesians is very high, which is around 95%, and 70% of these values occur above 30 years or the adult age group. There is controversy about whether dental calculus is an etiological factor in periodontal disease, or is it just a predisposing factor. Dental Calculus is a calcified oral ecosystem or dental plaque, can accumulate on supragingival or subgingival. Plaque is a bacterial biofilm complex on the tooth surface, including pathogenic microorganisms that invade periodontal tissue. Periodontal disease is the result of interactions between pathogens and the host immune system. Damage to periodontal tissue can occur if the pathogenicity of the microflora is more dominant in the immune response. In calcified conditions, these microorganisms lose their pathogenicity. The dental calculus is one form of the body's defense mechanism against pathogens. But the accumulation of dental calculus, with its rough surface, is a predisposing factor for plaque accumulation. The oral ecosystem trapping on the unique calcified material which are called dental calculus.

Minimum Inhibitory Concentration (MIC) and minimum bactericidal concentration of beluntas leaf ethanol extract against streptococcus mutans Elin Septiani; Natallia Pranata; Vinna K. Sugiaman
Journal of Dentomaxillofacial Science Vol. 7 No. 2 (2022): (Available online: 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v7i2.1388

bjective: The purpose of this study was to determine the exact values of MBC (Minimum Bactericidal Concentration) and MIC (Minimum Inhibitory Concentration) of beluntas leaf extract against Streptococcus mutans colonies. Material and Methood: This study used Streptococcus mutans ATCC 25175 and ethanol extract of beluntas leaves with concentrations: 250 g/ml, 125 g/ml, 62.5 g/ml, 31.3 g/ml, 15.6 g/ml, 7.8 g /ml, 3.9 g/ml and 1.95μg/ml. This study used two methods, Broth Microdilution and Total Plate Count techniques as the designated method for the purpose of counting bacteria. Furthermore, the data analysis test was carried out to analyze normality using the Kolmogorov-Smirnov test. If the data distribution shows normal, then one way ANOVA parametric test is performed to determine the significance between the beluntas leaf extract and the number of streptococcus mutans bacteria, which will then be further examined using the Post-Hoc Test with the Tuckey method to find out which dataset is the most significantly different in among others. Results: The beluntas leaf extract showed significant bacterial properties against Streptococcus mutans (P-Value = 0.00) which was expressed through definite MBC and MIC values. The results showed that the MIC and MBC values were 62.5 g/ml and 125 g/ml, respectively against Streptococcus mutans colonies. Conclusion: The conclusion of this study was that the ethanol extract of the leaves of beluntas (Pluchea Indica L) showed antibacterial properties as indicated by the MIC value at a concentration of 62.5μg/ml and the MBC at a concentration of 125μg/ml against streptococcus mutans.

EFEK ANTIBAKTERIAL CUKA SARI APEL DALAM BERBAGAIKONSENTRASI TERHADAP PORPHYROMONAS GINGIVALIS Sari Aliyani; Natallia Pranata; Vinna Kurniawati Sugiaman
Jurnal Ilmiah dan Teknologi Kedokteran Gigi Vol 19, No 1 (2023)
Publisher : Fakultas Kedokteran Gigi Universitas Prof. Dr. Moestopo (Beragama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32509/jitekgi.v19i1.2157

Latar belakang: penyakit periodontal adalah penyakit yang dapat mengenai jaringan pendukung gigi. American Academy of Periodontology (AAP) mengklasifikasikan menjadi dua, yaitu periodontitis kronis dan periodontitis agresif. Periodontitis biasanya disebabkan oleh bakteri salah satunya Porphyromonas gingivalis. Salah satu bahan yang dapat digunakan sebagai obat kumur dan memiliki efek antibakteri adalah chlorhexidine, namun penggunaan obat kumur ini memiliki efek samping sehingga masyarakat beralih ke obat herbal, yaitu cuka sari apel yang memiliki kandungan fenol, flavonoid, saponin, dan alkaloid sebagai antibakteri. Tujuan: penelitian ini bertujuan untuk mengetahui ada atau tidaknya efek antibakteri cuka sari apel terhadap bakteri Porphyromonas gingivalis.Metode: bahan berupa cuka sari apel hasil fermentasi memiliki nilai pH 3,13 dan kadar gula yang tersisa 1,5% Brix. Sampel penelitiannya adalah Porphyromonas gingivalis ATCC 33277, didapat dari Laboratorium Aretha Medika Utama Biomolecular and Biomedical Research Center (BBRC) Bandung. Metode penelitiannya adalah metode difusi cakram (Kirby-Bauer), yaitu metode pada kertas cakram dengan berbagai konsentrasi cuka sari apel. Hasil: berdasarkan hasil penelitian eksperimental laboratorium mengenai efek antibakteri cuka sari apel dengan konsetrasi 1,56% dan 3,12% memiliki kriteria lemah karena memiliki nilai 0, pada konsentrasi 6,25% dan 50%, memiliki kriteria sedang karena memiliki nilai 6,18 mm dan 8,33 mm, dan pada konsentrasi 100% memiliki kriteria kuat karena memiliki nilai 13,93 mm. Kesimpulan: pada cuka sari apel terdapat efek antibakteri yang mampu menghambat pertumbuhan bakteriPorphyromonas gingivalis, zona hambat terbesar terdapat pada konsentrasi 100% dan berkurang sejalan dengan penurunan konsentrasi cuka sari apel.

Phytochemical Features of Moringa oleifera Leaves as Anticancer Ludovicus Edwinanto; Endry Septiadi; Latifah R. Nurfazriah; Karina S. Anastasya; Natallia Pranata
Journal of Medicine and Health Vol 2 No 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i1.745

Cancer is a disease that can threaten human life. Various methods of cancer therapy havebeen widely practiced, one of which is chemotherapy. But the cost used for the therapy is alsovery expensive. This difficulty led many researchers to conduct research to find activecompounds from natural materials. Moringa leaf (Moringa oleifera) has cytotoxic activity,because it contains a lot of flavonoids. Flavonoids are polyphenol compounds produced fromsecondary metabolism in plants. The most flavonoids that are anticancer active substances inthe Moringa leaf are quercetin, kaempferol and myricetin. Cytotoxic activity because theseactive substances can induce apoptosis through intrinsic pathways by inhibition of mitogen-activated protein kinase (MAPK), extracellular-signal-regulated kinase 1/2 (ERK 1/2), c-Jun N-terminal protein kinase 1 (JNK), and protein kinase C (PKC).Keywords: Moringa leaf, quersetin; kaempferol; myricetin; anticancer

Viability of fibroblast cells on the clove (Syzygium aromaticum) leaves ethanol extract Felicia, Anindhita Cindy; Sugiaman, Vinna Kurniawati; Pranata, Natallia
Padjadjaran Journal of Dentistry Vol 31, No 1 (2019): March 2019
Publisher : Universitas Padjadjaran

Introduction: Various active compounds of herbal plants that are known to accelerate the wound healing process are flavonoids, tannins, and saponins. One amongst them is clove (Syzygium aromaticum), with the leaves as the most common part to be used as herbal medicine due to the antibacterial, anti-inflammatory, and antioxidant properties. However, the use of the biocompatibility of clove leaves as herbal medicine is still unknown. Therefore, this study was aimed to determine the cytotoxicity effects of clove leaves ethanol extract on the fibroblast cells and safe dosage (IC50) for medicinal use. Methods: Phytochemical tests using the Farnsworth method and viability test was performed using the laboratory experimental with post-test only control group design. The samples were divided into seven concentrations; 500, 250, 125, 62.5, 31.25, 15.63, and 7.81 μg/ml, with three repetitions (triplo) towards the fibroblast cells. Viability test was performed using MTS assay. Results: Based on the results obtained from one-way ANOVA statistical test, there was a significant difference between the percentage of cell viability and each concentration (α ≤ 0.05), with IC50 value of 344.814 μg/ml. Conclusion: Clove (Syzygium aromaticum) leaves ethanol extract showed a high percentage of cell viability at the concentrations below the IC50 value.Keywords: Clove leaves, cytotoxicity, fibroblast cell, MTS assay, periodontal diseases, viability.

Deteksi Dini Oral Squamous Sel Carcinoma (OSCC) dengan Menggunakan Human Papillomavirus (HPV) sebagai Penandanya Natallia Pranata
SONDE (Sound of Dentistry) Vol. 3 No. 2 (2018): SONDE (Sound of Dentistry)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/sod.v3i2.1787

Insidensi oral squamous cell carcinoma (OSCC) secara global diprediksi akan meningkat sekitar 62% pada tahun 2035. Salah satu pathogen yang dapat menyebabkan keganasan adalah human papillomavirus (HPV). Pada kasus OSCC sekitar 17% hingga 87% diakibatkan oleh infeksi HPV.1–3 OSCC memiliki prognosis yang baik jika terdeteksi pada tahap dini. Deteksi HPV pada OSCC menjadi biomarker penting, dan dapat digunakan sebagai screening populasi memiliki resiko terkena OSCC.

Gambaran Komplikasi Post Odontektomi Gigi Impaksi Molar Ketiga Rahang Bawah Tahun 2018 di RSGM X Bandung Neng Vivie Agustina Puspitasari; Borman Sumaji; Natallia Pranata
SONDE (Sound of Dentistry) Vol. 4 No. 2 (2019): SONDE (Sound of Dentistry)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/sod.v4i2.1913

Perkembangan dan pertumbuhan gigi sering mengalami gangguan pada saat erupsi. Gigi yang tidak berhasil erupsi dengan sempurna dan terpendam dalam rahang dengan posisi yang abnormal disebut impaksi. Frekuensi impaksi gigi yang paling sering terjadi adalah gigi molar ketiga rahang bawah. Impaksi gigi molar ketiga rahang bawah juga dapat mengganggu proses pengunyahan dan sering menyebabkan berbagai komplikasi, maka dari itu diperlukan pencabutan. Upaya mengeluarkan gigi impaksi terutama pada molar ketiga rahang bawah dilakukan dengan tindakan pembedahan yang disebut dengan odontektomi. Tujuan dari penelitian ini adalah mendapatkan informasi gambaran komplikasi pada pasien yang telah dilakukan odontektomi di RSGM X Bandung. Penelitian ini merupakan jenis penelitian observational yang dirancang secara deskriptif dengan metode cross sectional dan pengambilan data secara retrospektif. Pengambilan data Rekam Medis pasien pada Januari - Desember 2018 di RSGM X Bandung dengan hari kontrol pada hari ke 7. Hasil penelitian ini terdapat beberapa komplikasi post odontektomi gigi molar ketiga rahang bawah seperti trismus 1,62%, bengkak 4,22%, parestesia 0,32%, dry socket 1,94%, perdarahan 1,62%, sakit 17,2%, fraktur 0%. Komplikasi post odontektomi yang terjadi di RSGM X Bandung pada hari kontrol hari ke 7 setelah dilakukan odontektomi sebanyak 25,5%.

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