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All Journal JURNAL GIZI INDONESIA The Indonesian Biomedical Journal Indonesian Journal of Global Health research Media Penelitian dan Pengembangan Kesehatan
Wardhani, Lusi Oka
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Beetroot (Beta vulgaris L.) reduces cholesterol and triglyceride in dyslipidemic male rats sprague–dawley model Rohman, Yulia; Nurudhin, Arief; Wardhani, Lusi Oka
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 2 (2024): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.2.80-87

Abstract

Background: High-fat diets habit can lead to metabolic disorders, such as dyslipidemia which a significant contributor for cardiovascular diseases. Dyslipidemia occurs as a result of metabolically interrelated abnormalities of plasma lipids and lipoproteins, including low level of high-density lipoprotein cholesterol, and increasing of low density lipoprotein cholesterol, total cholesterol, and triglyceride. In order to enhance anti-lipid treatment, nutritional therapy containing bioactive compounds are investigated extensively, including those found in beetroot which shown potential in preventing and treating metabolic disorders.Objective: This study evaluated the effect of beetroot extract and beetroot juice on cholesterol and triglyceride levels as a dyslipidemia treatment, in comparison to simvastatin. Ethanol extract can attract flavonoids and betalain, but the extraction process can degrade fiber. Meanwhile, juice still contains quite a lot of fiber.Materials and Methods: Male Sprague Dawley rats were divided into seven groups and fed different diets for 56 days. The groups were: normal control (K0), negative control-HFD (KN), positive control-HFD + simvastatin (KP), single-dose treatment with BE (P1) or BJ (P2), and combination treatment with BE or BJ + simvastatin (P3 and P4), each intervention was given for 28 days. After blood drawn, cholesterol total and triglyceride serum were examined and analyzed.Results: Administration of beetroot extract and juice in single dose or combination with simvastatin gave a significant decrease in cholesterol and triglyceride levels compared to before the intervention. The average reduction levels of cholesterol in P1, P2, P3, and P4 were 54.81, 56.31, 94.19 and 69.11 respectively. Whereas the average decreasing level of triglyceride were 43.28, 30.78, 54.28 and 46.37 in P1, P2, P3 and P4 groups. Combination treatment with simvastatin gave more reduction level compared with single dose beetroot extract or beetroot juice. The most effective reduction was in the beet extract combination with simvastatin group were -94.19±4.08 mg/dL (cholesterol) and -54.28±6.93 mg/dL (triglyceride).Conclusion: Both beetroot extract and juice, as single or combined with simvastatin, were able to decrease cholesterol and triglyceride levels, these indicated their potential for prevention and therapeutic in dyslipidemia. Further research is needed to investigate its mechanisms and establish optimal dosages for human consumption.
Relationship between Stress Levels and UPF Consumption on Blood Pressure in Obese Adolescents Sutomo, Zahrina Fildza Luthfiana; Dewi, Yulia Lanti Retno; Wardhani, Lusi Oka
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6132

Abstract

Adolescent obesity is a growing global health problem, with the risk of developing hypertension due to activation of the sympathetic nervous system (SNS) and sodium regulation. Psychosocial stress and unhealthy diets, including consumption of Ultra-Processed Foods (UPF), contribute to increased blood pressure. UPF high in sodium, fat, and sugar are associated with hypertension, while stress can trigger emotional eating, increasing consumption of high-calorie foods. Adolescent diets tend to be low in fiber and high in UPF, supported by the school environment. This study aims to analyze the relationship between stress levels and UPF consumption on blood pressure in obese adolescents to understand the risk factors for hypertension in this group. This study used an analytical observational design with a cross-sectional approach. A sample of 75 students was selected by purposive sampling. Data were collected through interviews and measurements, then analyzed using SPSS version 29 statistically. The majority of respondents were 16 years old, male, with high UPF consumption. UPF consumption was significantly associated with diastolic blood pressure (p=0.036, r=0.255). Stress level was not significantly associated with blood pressure (p>0.05, r=0.1–0.2). Stress levels did not have a significant relationship with either systolic or diastolic blood pressure. UPF consumption was not significantly related to systolic blood pressure, but UPF consumption was significantly related to diastolic blood pressure.
Beetroot (Beta vulgaris L.) Extract Gives Superior Effect than Beetroot Juice on Increasing HDL and Decreasing LDL and IL-6 in Dyslipidemic Rats Model Riri, Miftahul Jannah; Harioputro, Dhani Redhono; Wardhani, Lusi Oka
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.2890

Abstract

BACKGROUND: Dyslipidemia derives from disturbances in lipid metabolism as an interaction between genetic and environmental factors, characterized by increased levels of cholesterol, triglycerides, low-density lipoprotein (LDL) and decreased levels of high-density lipoprotein (HDL). Continuous dyslipidemia will increase the risk of atherosclerosis. In dyslipidemia, macrophages release inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-12, IL-15, IL-18, and then induce T-cell infiltration formed atherosclerotic plaques. Beet (Beta vulgaris L.) which contains active compounds and antioxidant, such as flavonoids and betacyanin, has the ability to reduce dyslipidemia. This study evaluated effect of beetroot juice and beetroot extract on dyslipidemic rat models by evaluating the level of HDL, LDL and IL-6.METHODS: Fourty-two male Sprague Dawley rats were divided into seven groups. Rats were fed either with standard food or high fat diet (HFD) for 28 days, then different interventions using either single combination of simvastatin, beetroot juice, or beetroot extract were given alongside the standard food or HFD diet for another 28 days. LDL and HDL were measured pre- and post-intervention, while IL-6 was measured only post-treatment.RESULTS: Daily administration of a single beetroot juice or beetroot extract or in combination with simvastatin reduced LDL significantly compared to pre-intervention. The interventions also increased HDL significantly and lower IL-6 concentrations compared to group that received no intervention.CONCLUSION: Administration of beetroot juice and beetroot extract can lower LDL, increase HDL, and decrease IL-6 either alone or in combination treatment with simvastatin, it is indicated beetroot have a potential benefit for prevention and therapeutic in dyslipidemia.KEYWORDS: beetroot juice, beetroot extract, LDL, HDL, IL-6
PHYTOCHEMICAL AND NUTRIENT ANALYSIS OF ETHANOL EXTRACT SALAK PONDOH (Sallaca edulis Reinw) PEEL FOR DEVELOPMENT OF ANTI-OBESITY Andina, Puri Dwi; Indarto, Dono; Wardhani, Lusi Oka
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 2 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i2.2819

Abstract

Insiden obesitas meningkat di seluruh dunia selama beberapa tahun terakhir. Diet dan aktivitas fisik saja pada penderita obesitas kurang memberikan hasil yang optimal, sedangkan penggunaan obat anti obesitas dalam jangka panjang dapat menyebabkan efek samping. Penelitian ini bertujuan untuk menganalisis nutrisi dan kandungan fitokimia kulit buah salak pondoh untuk mengembangkan pengobatan obesitas. Jenis penelitian ini merupakan eksperimental laboratorium dengan 3 tahap: ekstraksi kulit luar salak pondoh, analisis nutrisi, dan analisis Gas Chromatography and Mass Spectrometry yang selanjutnya disebut GC-MS. Kulit buah salak pondoh diperoleh dari pusat agribisnis di Sleman, Yogyakarta. Kulit buah salak pondoh kering diekstraksi dengan etanol 70% menggunakan metode remaserasi. Kandungan nutrisi yang terdapat pada ekstrak etanol dianalisis di Laboratorium Teknologi Pangan, Fakultas Pertanian, Universitas Sebelas Maret, sedangkan analisis fitokimia dilakukan di Laboratorium Riset Terpadu dan Analisis Pengujian Universitas Gadjah Mada, dengan menggunakan metode Gas Chromatography and Mass Spectrometry (GC-MS). Ekstrak kulit buah salak pondoh (EPP) mengandung persentase karbohidrat (41,33%), mineral (28,37%), dan air (25,31%) yang lebih tinggi dibandingkan persentase serat kasar (3,68%), lemak (2,62%), protein (2,37%), dan vitamin C (0,88%). Hasil GC-MS mengidentifikasi adanya 75 fitokimia di mana dua dari lima senyawa dengan proporsi tertinggi adalah metil ester asam heksadekanoat dan asam n-heksadekanoat. Kandungan fitokimia tersebut memiliki aktivitas biologis yang berpotensi untuk pengembangan terapi obesitas. Perlu dilakukan penelitian lanjutan secara in vitro dan in vivo untuk mengevaluasi sifat anti- obesitas EPP tersebut.
Co-Authors Andina, Puri Dwi Arief Nurudhin Dono Indarto Harioputro, Dhani Redhono Riri, Miftahul Jannah Rohman, Yulia Sutomo, Zahrina Fildza Luthfiana yulia lanti retno dewi