Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kedokteran dan Kesehatan Borneo Journal of Pharmacy
Ahnafani, Miyada Nur
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Jahe (Zingiber Officinale): Tinjauan Fitokimia, Farmakologi, Dan Toksikologi Ahnafani, Miyada Nur; Nasiroh, Nasiroh; Aulia, Nina; Lestari, Noor Laili Mega; Ngongo, Marselina; Hakim, Ali Rakhman
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 10 (2024): Volume 11 Nomor 10
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i10.15945

Abstract

Tanaman obat yang banyak digunakan dalam pengobatan tradisional dan modern. Berdasarkan penelitian, Jahe mengandung senyawa seperti alkaloid, flavonoid, fenolik, triterpenoid, gingerol dan saponin yang berperan sebagai analgesik, antioksidan, antiinflamasi, dan antitumor. Dari segi farmakologi, jahe memiliki efek karminatif, stimulan pencernaan, vasodilator, ekspektoran, antibakteri, antipiretik antibakteri, antiinflamasi, analgesic, dan antioksidan. Toksikologi menunjukkan jahe umumnya aman, tetapi konsumsi berlebih bisa menyebabkan nyeri ulu hati dan iritasi lambung, serta reaksi alergi jika terhirup. Studi pada hewan dan manusia mengindikasikan jahe tidak meningkatkan risiko malformasi pada bayi selama kehamilan. Penelitian ini menegaskan manfaat kesehatan jahe dan pentingnya konsumsi dalam dosis tepat untuk menghindari toksisitas.
Combined Effects of Curcuma xanthorrhiza Rhizome and Persea americana Leaves Extracts on Streptozotocin-Induced Diabetes in Rats Thong, Vertirico; Ahnafani, Miyada Nur; Lestari, Helda Dwi; Ahnafani, Mayada Nur; Kurniawati, Darini
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.5837

Abstract

Indonesia's rich biodiversity encompasses numerous plants with ethnomedicinal applications, including avocado (Persea americana) leaves and temulawak (Curcuma xanthorrhiza) rhizomes, traditionally used for managing diabetes mellitus. This study investigated the antidiabetic activity of a combination of C. xanthorrhiza rhizomes and P. americana leaves in streptozotocin (STZ)-induced diabetic rats. Extracts were obtained via 72-hour maceration using 96% ethanol, followed by phytochemical screening and a 3-day toxicity assessment in rats at doses of 50, 150, and 200 mg/kg BW. Diabetic rats, induced with a single intraperitoneal injection of 20 mg/kg STZ, were treated for 14 days with three different combination formulas of C. xanthorrhiza rhizome and P. americana leaf extracts: Formula 1 (0.6 g : 0.4 g), Formula 2 (0.4 g : 0.6 g), and Formula 3 (0.4 g : 0.4 g). Metformin (500 mg/kg/day) served as the positive control, and 0.5% CMC-Na was the negative control. Phytochemical analysis revealed the presence of various bioactive compounds in both extracts. No significant toxicity was observed in rats across the tested doses. The Mann-Whitney test indicated a significant difference in blood glucose levels in diabetic rats after 14 days of treatment (p=0.037). Notably, all combination formulas exhibited antidiabetic activity. Specifically, Formula 1 demonstrated comparable antidiabetic efficacy to metformin (500 mg/kg). These findings suggest that combining C. xanthorrhiza and P. americana extracts possesses significant antidiabetic potential.
Co-Authors Ahnafani, Mayada Nur Ali Rakhman Hakim Aulia, Nina Kurniawati, Darini Lestari, Helda Dwi Lestari, Noor Laili Mega Nasiroh, Nasiroh Ngongo, Marselina Thong, Vertirico