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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Asian Journal of Health Research
Rasyida, Annisa Ullya
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Diagnostic and Treatment Challenges of Recurrent Tuberculosis in Patient with Drug-Induced Hepatotoxicity: A Case Report Devanda, Kasilda Pasha; Avelline, Kendraadine Dheayu; Lauwis, Keziah Queency; Kharizmatika; Hayati, Khofifah Bela Rachmanu; Adiwinoto, Ronald Pratama; Nugraheni, Pramita Anindya; Rasyida, Annisa Ullya
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.195

Abstract

Introduction: Pulmonary tuberculosis (TB) remains one of the most significant global health challenges, especially complicated by cases with incomplete treatment histories. The recurrence of TB poses diagnostic and therapeutic dilemmas that significantly impact patient outcomes. Case Presentation: We report a case of a 57-year-old female patient presenting with recurrent pulmonary TB after an incomplete treatment course. The patient's history revealed gaps in adherence to the prescribed TB regimen, leading to multiple relapses. In this study, we found that patients undergoing TB treatment may experience liver damage as a result of the TB medication, also known as DIH. Comprehensive diagnostic procedures, including chest radiography, sputum culture, and molecular testing, confirmed recurrent TB. The patient's clinical manifestations, treatment plan, and response to therapy are detailed. Conclusion: Recurrent TB is common, particularly in older adults, and is influenced more by environmental factors than occupation. Additionally, ATT poses risks of hepatotoxicity, especially in malnourished patients, underscoring the importance of managing side effects and addressing factors like malnutrition to prevent complications and improve outcomes. This case underscores the importance of complete adherence to TB treatment regimens and highlights the challenges in managing recurrent TB. It emphasizes the need for robust follow-up, patient education strategies, early diagnosis, and prompt intervention to prevent recurrence and enhance patient outcomes.
Effect of Rhizophora apiculata bark extract on SGOT levels in Rattus norvegicus induced by dexamethasone Sampurna, William Wijaya; Handajani, Fitri; Rasyida, Annisa Ullya; Nandaka, I Ketut Tirka
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 2 (2025): SEPTEMBER 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i2.4640

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Background: The liver's presence of fat has a histological picture with lipids>5%, and no secondary cause is called NAFLD. Rhizophora apiculata can serve as a therapeutic or prophylactic agent in NAFLD due to its flavonoid content. Objective: to ascertain the impact of Rhizophora apiculata extract administration on SGOT levels in white rats subjected to dexamethasone induction. Methods: The experimental animals were categorized into four groups: K- group, no treatment; K+ group, which was administered dexamethasone at a dosage of 5 mg/kg BW from the 15th to the 21st day; KP1 group, which received Rhizophora apiculata ethanol extract at a dosage of 56 mg/kg BW from the 8th to the 21st day, along with dexamethasone at 5 mg/kg BW from the 15th to the 21st day; and KP2 group, which was given Rhizophora apiculata ethanol extract at 56 mg/kg BW and dexamethasone at 5 mg/kg BW from the 15th to the 21st day. Result: The data were not normally distributed (p < 0.05), so the Kruskal-Wallis test was carried out, which yielded p < 0.05. Consequently, the post hoc test was continued, namely the Mann-Whitney U test. The post hoc test of the K-group and K+ obtained p < 0.05. The K+ group and KP1 and KP2 showed P > 0.05, indicating no significant difference. Conclusion: The Rhizophora apiculata extract at a dose of 56 mg/kg BW for 7 days can reduce SGOT levels in the Kp2 group.
Co-Authors Avelline, Kendraadine Dheayu Devanda, Kasilda Pasha Handajani, Fitri Hayati, Khofifah Bela Rachmanu I KETUT TIRKA NANDAKA Kharizmatika Lauwis, Keziah Queency Nugraheni, Pramita Anindya Ronald Pratama Adiwinoto Sampurna, William Wijaya