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Pemberdayaan Kader Kesehatan Ibu-Ibu Di Lingkungan Monjok Kebon Jaya Barat Melalui Pelatihan Pembuatan Sabun Herbal Daun Kelor (Moringa Oleifera) Aini, Diah Miftahul; Antari, Gladeva Yugi; Ratnasari, Baiq Desy
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.5919

Monjok Kebon Jaya Barat, Mataram, has rich natural resource potential, including the Moringa plant (Moringa oleifera) which is known for its skin health benefits. Although the local community has utilised moringa leaves in daily consumption, the great potential for further processing, such as making herbal soap, has not been maximised. Herbal soap made from moringa leaves can be a safer alternative to cleaning products, reduce dependence on harmful chemicals, and support a green economy. This programme aims to empower women health cadres in Monjok Kebon Jaya Barat through skills training in making herbal soap made from moringa leaves. The method used involved three main stages: activity preparation, soap-making training, and sustainability evaluation. In the training, participants were given theoretical and practical knowledge on the benefits of moringa leaves, the saponification process, and herbal soap making. The evaluation showed that most participants were able to follow the training well, although there were some technical constraints related to ingredient measurement and temperature control. The programme had a positive impact on skills enhancement and economic empowerment. The training is effective in introducing herbal soap making and can be a sustainable business opportunity. It is recommended to provide continuous assistance in marketing and the formation of joint business groups to improve the sustainability and welfare of the local community.

Synthesis and characterization of 2,4,6-trihydroxy benzophenone and its activity as sunscreen Yuanita, Emmy; Rohmana, Ainni; Ulfa, Maria; Ningsih, Baiq Nila Sari; Sudirman, Sudirman; Dharmayani, Ni Komang Tri; Lestarini, Ima Arum; Septiyana, Maulida; Ratnasari, Baiq Desy
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.175

Benzophenone was synthesized through a condensation reaction of benzoic acid and phloroglucinol with an Eaton reagent as a catalyst. The percentage of the product was 60%, and it was characterized using FTIR and 1H-NMR. The sunscreen activity was carried out using a UV-Vis spectrophotometer to calculate the SPF value. The synthesis result was made in several concentration variations: 100, 150, 200, 250, and 300 ppm to measure the SPF values. The results showed that the SPF values were 9.89, 13.39, 17.83, 23.77, and 28.26, respectively. Based on this, it can be concluded that these compounds have biological activity as sunscreen and samples of 200-300 ppm are included in the ultra-category as sunscreen.

The Unique Properties of Moringa Oleifera Extract in Soap Optimization: A Scientific Approach Aini, Diah Miftahul; Ratnasari, Baiq Desy
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4799

Moringa leaves (Moringa oleifera), a valuable source of bioactive compounds, including flavonoids, phenolic acids, tannin, and terpenoids. These compounds provide significant benefits to the skin, due to their antioxidant, anti-inflammatory, and antimicrobial properties. The chemical composition of these leaves has been demonstrated to enhance dermal hydration and provide protection against environmental stressors. By balancing Moringa with other natural ingredients such as coconut, olive, and palm oil, the efficacy of skincare formulation can be optimized, resulting in improved texture, stability, and consumer appeal. This research aims to optimize the soap's effectiveness by enhancing its properties, such as cleansing, moisturizing, and antimicrobial functions, using the unique characteristics of Moringa oleifera. The initial step involved of an ethanol extract of Moringa leaves, which was then subjected to analysis using Gas Chromatography-Mass Spectrometry (GC-MS). The analysis revealed that Moringa leaves contain eight key compounds, including 2.4(1H,3H)-pyrimidineodione, glycerol, 2,3-dihydro-3,5-dihydroxy-6-methyl-, 4,3-allyl-6-methoxyphenol, epoxylinalool, 1H-pyrrole, 2-(2,4,6-heptatrienyl), tetradecanoics acid, and hexadecanoic acid. The aforementioned compounds were used to formulate a soap base containing Moringa leaves. The resulting soap exhibit a pleasant fragrance, a dense texture, yellow slightly white in color, and a pH of 10, as confirmed by organoleptic and pH test. The recent focus resulting in the development of Moringa-based skincare product that are not only effective but also eco-friendly. Present study represents a promising approach to natural solution that cater to diverse skin types and consumer preferences.

IN SILICO INVESTIGATION OF MOLECULAR INTERACTIONS BETWEEN INULOSUCRASE DERIVED FROM Aspergillus awamori AND EPE COMPOUNDS Aini, Diah Miftahul; Fajriati, Elza Kamila; Yuanita, Emmy; Antari, Gladeva Yugi; Ratnasari, Baiq Desy; Damayanti, Eva Hikmatul
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 2 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i2.96978

Fructooligosaccharides (FOS) are important prebiotics synthesized by the enzymatic activity of inulosucrase, and understanding their molecular interactions is essential for exploring potential modulators. This study examined the interaction between inulosucrase from Aspergillus awamori (PDB ID: 1Y4W) and the compound EPE (4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid) using an in silico molecular docking approach. Since the 1Y4W structure lacks a co-crystallized ligand, EPE was selected as a surrogate ligand derived from PDB ID: 3SC7 and prepared for docking simulations. Docking with AutoDock Vina produced a best binding affinity of "“5.6 kcal/mol, with the strongest hydrogen bond observed with TRP305 (1.92 Ã…) and additional interactions with TYR279 (3.75 Ã…). These results indicate a moderate but stable interaction, weaker than the native substrate fructose reported in crystallographic studies. Overall, EPE shows potential as a modulatory compound of inulosucrase activity and provides a basis for further enzymological and biotechnological research.

Pemberdayaan Kader Kesehatan Ibu-Ibu Di Lingkungan Monjok Kebon Jaya Barat Melalui Pelatihan Pembuatan Sabun Herbal Daun Kelor (Moringa Oleifera) Aini, Diah Miftahul; Antari, Gladeva Yugi; Ratnasari, Baiq Desy
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.5919

Monjok Kebon Jaya Barat, Mataram, has rich natural resource potential, including the Moringa plant (Moringa oleifera) which is known for its skin health benefits. Although the local community has utilised moringa leaves in daily consumption, the great potential for further processing, such as making herbal soap, has not been maximised. Herbal soap made from moringa leaves can be a safer alternative to cleaning products, reduce dependence on harmful chemicals, and support a green economy. This programme aims to empower women health cadres in Monjok Kebon Jaya Barat through skills training in making herbal soap made from moringa leaves. The method used involved three main stages: activity preparation, soap-making training, and sustainability evaluation. In the training, participants were given theoretical and practical knowledge on the benefits of moringa leaves, the saponification process, and herbal soap making. The evaluation showed that most participants were able to follow the training well, although there were some technical constraints related to ingredient measurement and temperature control. The programme had a positive impact on skills enhancement and economic empowerment. The training is effective in introducing herbal soap making and can be a sustainable business opportunity. It is recommended to provide continuous assistance in marketing and the formation of joint business groups to improve the sustainability and welfare of the local community.

Molecular docking study of mutant levansucrase (E342A) from Bacillus subtilis as a receptor for D-glucopyranose and β-D-fructofuranose ligands: Molecular docking study of mutant levansucrase Aini, Diah Miftahul; Irmayanti, Firda Ade; Yuanita, Emmy; Septiyana, Maulida; Ratnasari, Baiq Desy
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.262

Molecular docking is a widely applied computational approach for predicting the binding modes of small-molecule ligands within the active site of a target protein. This research investigated the interactions of mutant levansucrase E342A from Bacillus subtilis (PDB ID: 1PT2) for β-D-fructofuranose and D-glucopyranose ligands. Using AutoDock Vina, the docking results indicated that β-D-fructofuranose exhibited a higher binding energy of –5.6 kcal/mol, compared to D-glucopyranose with a value of –5.4 kcal/mol, suggesting a more stable interaction. It was supported by the binding interaction analysis of β-D-fructofuranose, which established five hydrogen bonds, including direct interactions with the key catalytic residues Asp86 (2.76 Å) and Asp247 (2.64 Å) that are essential for the enzymatic reaction. In contrast, D-glucopyranose formed four hydrogen bonds, involving Arg360 (3.07 Å) and Glu340 (2.64 Å), with most residues contributing to structural stabilization rather than direct catalysis. These results confirm that β-D-fructofuranose plays a crucial role as a determinant of levansucrase activity in the biosynthesis of levan-type FOS, which are known to exhibit strong prebiotic activity.

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